| Lipid-sorting specificity encoded in K-Ras membrane anchor regulates signal output Y Zhou, P Prakash, H Liang, KJ Cho, AA Gorfe, JF Hancock Cell 168 (1), 239-251. e16, 2017 | 267 | 2017 |
| Oncogenic K-Ras binds to an anionic membrane in two distinct orientations: a molecular dynamics analysis P Prakash, Y Zhou, H Liang, JF Hancock, AA Gorfe Biophysical journal 110 (5), 1125-1138, 2016 | 138 | 2016 |
| Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers P Prakash, A Sayyed-Ahmad, KJ Cho, DM Dolino, W Chen, H Li, BJ Grant, ... Scientific reports 7 (1), 40109, 2017 | 103 | 2017 |
| Spatiotemporal analysis of K-Ras plasma membrane interactions reveals multiple high order homo-oligomeric complexes S Sarkar-Banerjee, A Sayyed-Ahmad, P Prakash, KJ Cho, MN Waxham, ... Journal of the American Chemical Society 139 (38), 13466-13475, 2017 | 85 | 2017 |
| Ras and the plasma membrane: a complicated relationship Y Zhou, P Prakash, AA Gorfe, JF Hancock Cold Spring Harbor perspectives in medicine 8 (10), a031831, 2018 | 82 | 2018 |
| Discovery of high-affinity noncovalent allosteric KRAS inhibitors that disrupt effector binding MJ McCarthy, CV Pagba, P Prakash, AK Naji, D van der Hoeven, H Liang, ... ACS omega 4 (2), 2921-2930, 2019 | 78 | 2019 |
| •Binding hotspots on K-Ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis P Prakash, J Hancock, A Gorfe Proteins, 2015 | 76 | 2015 |
| Dynamics of membrane-bound G12V-KRAS from simulations and single-molecule FRET in native nanodiscs P Prakash, D Litwin, H Liang, S Sarkar-Banerjee, D Dolino, Y Zhou, ... Biophysical journal 116 (2), 179-183, 2019 | 61 | 2019 |
| Lessons from computer simulations of Ras proteins in solution and in membrane P Prakash, AA Gorfe Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (11), 5211-5218, 2013 | 61 | 2013 |
| AMPK and endothelial nitric oxide synthase signaling regulates K-Ras plasma membrane interactions via cyclic GMP-dependent protein kinase 2 K Cho, DE Casteel, P Prakash, L Tan, D van der Hoeven, AA Salim, ... Molecular and Cellular Biology, 2016 | 58 | 2016 |
| A “tug of war” maintains a dynamic protein–membrane complex: molecular dynamics simulations of C-Raf RBD-CRD bound to K-Ras4B at an anionic membrane ZL Li, P Prakash, M Buck ACS central science 4 (2), 298-305, 2018 | 57 | 2018 |
| The role of conserved waters in conformational transitions of Q61H K-ras P Prakash, A Sayyed-Ahmad A, Gorfe Plos Computational Biology 8 (2), e1002394, 2012 | 56 | 2012 |
| Distinct dynamics and interaction patterns in H‐and K‐Ras oncogenic P‐loop mutants A Sayyed‐Ahmad, P Prakash, AA Gorfe Proteins: Structure, Function, and Bioinformatics 85 (9), 1618-1632, 2017 | 51 | 2017 |
| Membrane orientation dynamics of lipid-modified small GTPases P Prakash, AA Gorfe Small GTPases 8 (3), 129-138, 2017 | 46 | 2017 |
| Probing the conformational and energy landscapes of KRAS membrane orientation P Prakash, AA Gorfe The Journal of Physical Chemistry B 123 (41), 8644-8652, 2019 | 42 | 2019 |
| Multi‐target, ensemble‐based virtual screening yields novel allosteric KRAS inhibitors at high success rate AK Gupta, X Wang, CV Pagba, P Prakash, S Sarkar‐Banerjee, J Putkey, ... Chemical biology & drug design 94 (2), 1441-1456, 2019 | 37 | 2019 |
| pMD-membrane: A method for ligand binding site identification in membrane-bound protein P Prakash, A Sayyed-Ahmad, A Gorfe PloS Compuational Biology, 2015 | 37 | 2015 |
| Aggregation behavior of ibuprofen, cholic acid and dodecylphosphocholine micelles P Prakash, A Sayyed-Ahmad, Y Zhou, DE Volk, DG Gorenstein, E Dial, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (12), 3040-3047, 2012 | 36 | 2012 |
| The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure Y Zhou, PS Prakash, H Liang, AA Gorfe, JF Hancock Proceedings of the National Academy of Sciences 118 (6), e2014605118, 2021 | 30 | 2021 |
| Computational allosteric ligand binding site identification on Ras proteins M Mccarthy, P Prakash, A Gorfe | 30 | 2015 |
Alemayehu (Alex) GorfeProfessor, University of Texas McGovern Medical School-Houston在 uth.tmc.edu 的电子邮件经过验证
