Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection J Eyquem, J Mansilla-Soto, T Giavridis, SJC van der Stegen, M Hamieh, ... Nature 543 (7643), 113-117, 2017 | 1755 | 2017 |
CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade T Giavridis, SJC van der Stegen, J Eyquem, M Hamieh, A Piersigilli, ... Nature Medicine 24 (6), 731–738, 2018 | 1108 | 2018 |
Senolytic CAR T cells reverse senescence-associated pathologies C Amor, J Feucht, J Leibold, YJ Ho, C Zhu, D Alonso-Curbelo, ... Nature 583 (7814), 127-132, 2020 | 631 | 2020 |
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape M Hamieh, A Dobrin, A Cabriolu, SJC van der Stegen, T Giavridis, ... Nature 568 (7750), 112-116, 2019 | 495 | 2019 |
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy EC Morris, SS Neelapu, T Giavridis, M Sadelain Nature Reviews Immunology 22 (2), 85-96, 2022 | 461 | 2022 |
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells K Mestermann, T Giavridis, J Weber, J Rydzek, S Frenz, T Nerreter, ... Science translational medicine 11 (499), eaau5907, 2019 | 410 | 2019 |
HLA-independent T cell receptors for targeting tumors with low antigen density J Mansilla-Soto, J Eyquem, S Haubner, M Hamieh, J Feucht, N Paillon, ... Nature Medicine 28 (2), 345-352, 2022 | 97 | 2022 |
Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function N Jain, Z Zhao, RP Koche, C Antelope, Y Gozlan, A Montalbano, D Brocks, ... Cancer Discovery, 2023 | 6 | 2023 |
Novel therapeutic interventions to alleviate CAR T cell-induced cytokine release syndrome T Giavridis, SJ Stegen, J Eyquem, M Hamieh, M Sadelain Cancer Research 78 (13_Supplement), 2567-2567, 2018 | 1 | 2018 |
132 HLA-independent T cell receptors effectively target low abundance antigens J Mansilla-Soto, J Eyquem, S Haubner, M Hamieh, J Feucht, N Paillon, ... Journal for Immunotherapy of Cancer 9 (Suppl 2), A142-A142, 2021 | | 2021 |
Methods and compositions for alleviating cytokine release syndrome M Sadelain, T Giavridis US Patent App. 15/931,027, 2020 | | 2020 |
Restraining Macrophages Alleviates CAR T Cell-Induced Cytokine Release Syndrome and Informs Novel Therapeutic Interventions T Giavridis, SJC van der Stegen, J Eyquem, M Hamieh, M Sadelain MOLECULAR THERAPY 26 (5), 173-173, 2018 | | 2018 |
CRISPR/Cas9-Mediated Targeting of a CAR into the TRAC Locus Enhances CAR T Cell-Mediated Tumor Rejection J Mansilla-Soto, J Eyquem, T Giavridis, SJC van der Stegen, M Hamieh, ... MOLECULAR THERAPY 25 (5), 229-229, 2017 | | 2017 |