Cathepsin K: a unique collagenolytic cysteine peptidase M Novinec, B Lenarčič Biological chemistry 394 (9), 1163-1179, 2013 | 144 | 2013 |
Papain-like peptidases: structure, function, and evolution M Novinec, B Lenarčič Biomolecular concepts 4 (3), 287-308, 2013 | 124 | 2013 |
Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors M Novinec, RN Grass, WJ Stark, V Turk, A Baici, B Lenarčič Journal of Biological Chemistry 282 (11), 7893-7902, 2007 | 115 | 2007 |
A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods M Novinec, M Korenč, A Caflisch, R Ranganathan, B Lenarčič, A Baici Nature communications 5 (1), 3287, 2014 | 100 | 2014 |
Conformational flexibility and allosteric regulation of cathepsin K M Novinec, L Kovačič, B Lenarčič, A Baici Biochemical Journal 429 (2), 379-389, 2010 | 91 | 2010 |
Diversity and evolution of the thyroglobulin type-1 domain superfamily M Novinec, D Kordiš, V Turk, B Lenarcic Molecular biology and evolution 23 (4), 744-755, 2006 | 65 | 2006 |
Cysteine cathepsin activity regulation by glycosaminoglycans M Novinec, B Lenarčič, B Turk BioMed research international 2014 (1), 309718, 2014 | 62 | 2014 |
Orthocaspases are proteolytically active prokaryotic caspase homologues: the case of Microcystis aeruginosa M Klemenčič, M Novinec, M Dolinar Molecular Microbiology 98 (1), 142-150, 2015 | 50 | 2015 |
Cathepsin K cleavage of SDF-1α inhibits its chemotactic activity towards glioblastoma stem-like cells VVV Hira, U Verbovšek, B Breznik, M Srdič, M Novinec, H Kakar, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (3), 594-603, 2017 | 46 | 2017 |
Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria A Bubik, B Sedmak, M Novinec, B Lenarčič, TT Lah Walter de Gruyter 389 (10), 1339-1346, 2008 | 43 | 2008 |
A simple and efficient protocol for the production of recombinant cathepsin V and other cysteine cathepsins in soluble form in Escherichia coli M Novinec, M Pavšič, B Lenarčič Protein Expression and Purification 82 (1), 1-5, 2012 | 32 | 2012 |
Recombinant human SMOCs produced by in vitro refolding: calcium-binding properties and interactions with serum proteins M Novinec, L Kovačič, N Škrlj, V Turk, B Lenarčič Protein expression and purification 62 (1), 75-82, 2008 | 29 | 2008 |
The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties M Klemenčič, M Novinec, S Maier, U Hartmann, B Lenarčič PloS one 8 (2), e56839, 2013 | 28 | 2013 |
The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B M Paireder, S Tholen, A Porodko, ML Biniossek, B Mayer, M Novinec, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1865 (4), 444-452, 2017 | 25 | 2017 |
Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease M Niemer, U Mehofer, M Verdianz, A Porodko, P Schähs, D Kracher, ... Biochimie 122, 119-125, 2016 | 25 | 2016 |
Probing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiers M Novinec, B Lenarčič, A Baici PLoS One 9 (9), e106642, 2014 | 25 | 2014 |
The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity M Paireder, U Mehofer, S Tholen, A Porodko, P Schähs, D Maresch, ... Archives of Biochemistry and Biophysics 603, 110-117, 2016 | 24 | 2016 |
Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication J Kladnik, A Dolinar, J Kljun, D Perea, J Grau-Expósito, M Genescà, ... Journal of enzyme inhibition and medicinal chemistry 37 (1), 2158-2168, 2022 | 23 | 2022 |
Human cathepsin L, a papain‐like collagenase without proline specificity M Korenč, B Lenarčič, M Novinec The FEBS journal 282 (22), 4328-4340, 2015 | 23 | 2015 |
An allosteric site enables fine‐tuning of cathepsin K by diverse effectors M Novinec, M Rebernik, B Lenarčič Febs Letters 590 (24), 4507-4518, 2016 | 20 | 2016 |