Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity KE Larrimore, IC Kazan, L Kannan, RP Kendle, T Jamal, M Barcus, ... Scientific reports 7 (1), 10419, 2017 | 36 | 2017 |
Protein folding stability and binding interactions through the lens of evolution: a dynamical perspective T Modi, P Campitelli, IC Kazan, SB Ozkan Current opinion in structural biology 66, 207-215, 2021 | 33 | 2021 |
Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants NJ Ose, BM Butler, A Kumar, IC Kazan, M Sanderford, S Kumar, ... PLoS computational biology 18 (4), e1010006, 2022 | 22 | 2022 |
Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs BM Butler, IC Kazan, A Kumar, SB Ozkan PLoS computational biology 14 (11), e1006626, 2018 | 18 | 2018 |
Investigating the allosteric response of the PICK1 PDZ domain to different ligands with all‐atom simulations AO Stevens, IC Kazan, B Ozkan, Y He Protein Science 31 (12), e4474, 2022 | 13 | 2022 |
The role of rigid residues in modulating TEM-1 β-lactamase function and thermostability B Kolbaba-Kartchner, IC Kazan, JH Mills, SB Ozkan International journal of molecular sciences 22 (6), 2895, 2021 | 10 | 2021 |
Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations IC Kazan, P Sharma, MI Rahman, A Bobkov, R Fromme, G Ghirlanda, ... Elife 11, e67474, 2022 | 9 | 2022 |
Allosteric regulatory control in dihydrofolate reductase is revealed by dynamic asymmetry IC Kazan, JH Mills, SB Ozkan Protein Science 32 (8), e4700, 2023 | 6 | 2023 |
Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics NJ Ose, P Campitelli, T Modi, IC Kazan, S Kumar, SB Ozkan Elife 12, RP92063, 2024 | 2 | 2024 |
A method for the incorporation of protein dynamics into computational enzyme design using the Rosetta software suite BK Kartchner, IC Kazan, SB Ozkan, JH Mills Biophysical Journal 118 (3), 320a-321a, 2020 | 1 | 2020 |
Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity (vol 7 … KE Larrimore, I Kazan, L Kannan, R Kendle, T Jamal, M Barcus, A Bolia, ... SCIENTIFIC REPORTS 8, 2018 | 1 | 2018 |
Evidence that the cold-and menthol-sensing functions of the human TRPM8 channel evolved separately DD Luu, N Ramesh, IC Kazan, KH Shah, G Lahiri, MD Mana, SB Ozkan, ... Science Advances 10 (25), eadm9228, 2024 | | 2024 |
Enhancing deep learning model design through protein dynamics information integration J Lu, ICJ Kazan, BK Kartchner, N Huynh, JH Mills, SB Ozkan Biophysical Journal 123 (3), 207a-208a, 2024 | | 2024 |
Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis ICJ Kazan, J Lu, MI Rahman, N Halloran, AA Bobkov, SB Ozkan, ... Biophysical Journal 123 (3), 64a, 2024 | | 2024 |
Engineering gain‐of‐function mutants of a WW domain by dynamics and structural analysis J Lu, MI Rahman, IC Kazan, NR Halloran, AA Bobkov, SB Ozkan, ... Protein Science 32 (9), e4759, 2023 | | 2023 |
Understanding the evolution of cold sensing and menthol activation in TRPM8 N Ramesh, D Luu, KH Shah, ICJ Kazan, SB Ozkan, WD Van Horn Biophysical journal 122 (3), 197a, 2023 | | 2023 |
Allosteric regulatory control in dihydrofolate reductase (DHFR) revealed with dynamic asymmetry in unliganded ensemble ICJ Kazan, JH Mills, SB Ozkan Biophysical Journal 122 (3), 48a, 2023 | | 2023 |
Evolutionary Guided Molecular Dynamics Driven Protein Design IC Kazan Arizona State University, 2023 | | 2023 |
Track: Protein and Ligand-A New Marriage Between an Old Couple Functional Ancestral Reconstruction of the Cold and Menthol Sensor TRPM8 D Luu, K Shah, N Ramesh, I Kazan, SB Ozkan, W Van Horn PROTEIN SCIENCE 32, 2023 | | 2023 |
Adaptive Evolution of SARS-CoV-2: A Perspective from Dynamics IC Kazan, SB Ozkan Biophysical Journal 120 (3), 300a-301a, 2021 | | 2021 |