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I Can Kazan
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Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity
KE Larrimore, IC Kazan, L Kannan, RP Kendle, T Jamal, M Barcus, ...
Scientific reports 7 (1), 10419, 2017
362017
Protein folding stability and binding interactions through the lens of evolution: a dynamical perspective
T Modi, P Campitelli, IC Kazan, SB Ozkan
Current opinion in structural biology 66, 207-215, 2021
332021
Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants
NJ Ose, BM Butler, A Kumar, IC Kazan, M Sanderford, S Kumar, ...
PLoS computational biology 18 (4), e1010006, 2022
222022
Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs
BM Butler, IC Kazan, A Kumar, SB Ozkan
PLoS computational biology 14 (11), e1006626, 2018
182018
Investigating the allosteric response of the PICK1 PDZ domain to different ligands with all‐atom simulations
AO Stevens, IC Kazan, B Ozkan, Y He
Protein Science 31 (12), e4474, 2022
132022
The role of rigid residues in modulating TEM-1 β-lactamase function and thermostability
B Kolbaba-Kartchner, IC Kazan, JH Mills, SB Ozkan
International journal of molecular sciences 22 (6), 2895, 2021
102021
Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations
IC Kazan, P Sharma, MI Rahman, A Bobkov, R Fromme, G Ghirlanda, ...
Elife 11, e67474, 2022
92022
Allosteric regulatory control in dihydrofolate reductase is revealed by dynamic asymmetry
IC Kazan, JH Mills, SB Ozkan
Protein Science 32 (8), e4700, 2023
62023
Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics
NJ Ose, P Campitelli, T Modi, IC Kazan, S Kumar, SB Ozkan
Elife 12, RP92063, 2024
22024
A method for the incorporation of protein dynamics into computational enzyme design using the Rosetta software suite
BK Kartchner, IC Kazan, SB Ozkan, JH Mills
Biophysical Journal 118 (3), 320a-321a, 2020
12020
Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity (vol 7 …
KE Larrimore, I Kazan, L Kannan, R Kendle, T Jamal, M Barcus, A Bolia, ...
SCIENTIFIC REPORTS 8, 2018
12018
Evidence that the cold-and menthol-sensing functions of the human TRPM8 channel evolved separately
DD Luu, N Ramesh, IC Kazan, KH Shah, G Lahiri, MD Mana, SB Ozkan, ...
Science Advances 10 (25), eadm9228, 2024
2024
Enhancing deep learning model design through protein dynamics information integration
J Lu, ICJ Kazan, BK Kartchner, N Huynh, JH Mills, SB Ozkan
Biophysical Journal 123 (3), 207a-208a, 2024
2024
Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis
ICJ Kazan, J Lu, MI Rahman, N Halloran, AA Bobkov, SB Ozkan, ...
Biophysical Journal 123 (3), 64a, 2024
2024
Engineering gain‐of‐function mutants of a WW domain by dynamics and structural analysis
J Lu, MI Rahman, IC Kazan, NR Halloran, AA Bobkov, SB Ozkan, ...
Protein Science 32 (9), e4759, 2023
2023
Understanding the evolution of cold sensing and menthol activation in TRPM8
N Ramesh, D Luu, KH Shah, ICJ Kazan, SB Ozkan, WD Van Horn
Biophysical journal 122 (3), 197a, 2023
2023
Allosteric regulatory control in dihydrofolate reductase (DHFR) revealed with dynamic asymmetry in unliganded ensemble
ICJ Kazan, JH Mills, SB Ozkan
Biophysical Journal 122 (3), 48a, 2023
2023
Evolutionary Guided Molecular Dynamics Driven Protein Design
IC Kazan
Arizona State University, 2023
2023
Track: Protein and Ligand-A New Marriage Between an Old Couple Functional Ancestral Reconstruction of the Cold and Menthol Sensor TRPM8
D Luu, K Shah, N Ramesh, I Kazan, SB Ozkan, W Van Horn
PROTEIN SCIENCE 32, 2023
2023
Adaptive Evolution of SARS-CoV-2: A Perspective from Dynamics
IC Kazan, SB Ozkan
Biophysical Journal 120 (3), 300a-301a, 2021
2021
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