Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink KR Schramma, LB Bushin, MR Seyedsayamdost Nature chemistry 7 (5), 431-437, 2015 | 221 | 2015 |
Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens F Xu, B Nazari, K Moon, LB Bushin, MR Seyedsayamdost Journal of the American Chemical Society 139 (27), 9203-9212, 2017 | 156 | 2017 |
A genetics-free method for high-throughput discovery of cryptic microbial metabolites F Xu, Y Wu, C Zhang, KM Davis, K Moon, LB Bushin, ... Nature chemical biology 15 (2), 161-168, 2019 | 132 | 2019 |
Charting an unexplored streptococcal biosynthetic landscape reveals a unique peptide cyclization motif LB Bushin, KA Clark, I Pelczer, MR Seyedsayamdost Journal of the American Chemical Society 140 (50), 17674-17684, 2018 | 88 | 2018 |
Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264 D Mao, LB Bushin, K Moon, Y Wu, MR Seyedsayamdost Proceedings of the National Academy of Sciences 114 (14), E2920-E2928, 2017 | 82 | 2017 |
Radical approach to enzymatic β-thioether bond formation A Caruso, LB Bushin, KA Clark, RJ Martinie, MR Seyedsayamdost Journal of the American Chemical Society 141 (2), 990-997, 2018 | 77 | 2018 |
Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis BK Okada, Y Wu, D Mao, LB Bushin, MR Seyedsayamdost ACS chemical biology 11 (8), 2124-2130, 2016 | 74 | 2016 |
Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes A Caruso, RJ Martinie, LB Bushin, MR Seyedsayamdost Journal of the American Chemical Society 141 (42), 16610-16614, 2019 | 68 | 2019 |
Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae M Metelev, A Arseniev, LB Bushin, K Kuznedelov, TO Artamonova, ... ACS chemical biology 12 (3), 814-824, 2017 | 58 | 2017 |
Aliphatic ether bond formation expands the scope of radical SAM enzymes in natural product biosynthesis KA Clark, LB Bushin, MR Seyedsayamdost Journal of the American Chemical Society 141 (27), 10610-10615, 2019 | 55 | 2019 |
Discovery and biosynthesis of streptosactin, a sactipeptide with an alternative topology encoded by commensal bacteria in the human microbiome LB Bushin, BC Covington, BE Rued, MJ Federle, MR Seyedsayamdost Journal of the American Chemical Society 142 (38), 16265-16275, 2020 | 53 | 2020 |
Total synthesis and stereochemical assignment of streptide NA Isley, Y Endo, ZC Wu, BC Covington, LB Bushin, MR Seyedsayamdost, ... Journal of the American Chemical Society 141 (43), 17361-17369, 2019 | 52 | 2019 |
Quorum sensing in streptococcus mutans regulates production of tryglysin, a novel ras-ripp antimicrobial compound BE Rued, BC Covington, LB Bushin, G Szewczyk, I Laczkovich, ... MBio 12 (2), 10.1128/mbio. 02688-20, 2021 | 34 | 2021 |
RaS-riPPs in streptococci and the human microbiome KA Clark, LB Bushin, MR Seyedsayamdost ACS bio & med Chem Au 2 (4), 328-339, 2022 | 23 | 2022 |
Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs LB Bushin, BC Covington, KA Clark, A Caruso, MR Seyedsayamdost Nature Chemical Biology 18 (10), 1135-1143, 2022 | 18 | 2022 |
Backbone-enabled peptide macrocyclization through late-stage palladium-catalyzed C–H activation Z Bai, H Wang Synlett 31 (03), 199-204, 2020 | 18 | 2020 |
Guidelines for determining the structures of radical SAM enzyme-catalyzed modifications in the biosynthesis of RiPP natural products LB Bushin, MR Seyedsayamdost Methods in Enzymology 606, 439-460, 2018 | 12 | 2018 |
Mapping the trimethoprim-induced secondary metabolome of Burkholderia thailandensis. ACS Chem Biol 11: 2124–2130 BK Okada, Y Wu, D Mao, LB Bushin, MR Seyedsayamdost | 9 | 2016 |
Expanding the Landscape of Noncanonical Amino Acids in RiPP Biosynthesis BA Johnson, KA Clark, LB Bushin, CN Spolar, MR Seyedsayamdost Journal of the American Chemical Society, 2024 | 2 | 2024 |
Cryptic metabolites and method for activating silent biosynthetic gene clusters in diverse microorganisms MR Seyedsayamdost, F Xu, WU Yihan, L Bushin, K Davis US Patent 11,549,950, 2023 | 1 | 2023 |