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Brenton R Paolella
Brenton R Paolella
Broad Institute of MIT and Harvard
在 broadinstitute.org 的电子邮件经过验证 - 首页
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引用次数
引用次数
年份
Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
25042019
BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
P Bandopadhayay, G Bergthold, B Nguyen, S Schubert, S Gholamin, ...
Clinical Cancer Research 20 (4), 912-925, 2014
3812014
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
P Bandopadhayay, LA Ramkissoon, P Jain, G Bergthold, J Wala, R Zeid, ...
Nature genetics 48 (3), 273-282, 2016
2782016
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
JM McFarland, BR Paolella, A Warren, K Geiger-Schuller, T Shibue, ...
Nature communications 11 (1), 4296, 2020
1082020
A first-generation pediatric cancer dependency map
NV Dharia, G Kugener, LM Guenther, CF Malone, AD Durbin, AL Hong, ...
Nature genetics 53 (4), 529-538, 2021
982021
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers
T Ito, MJ Young, R Li, S Jain, A Wernitznig, JM Krill-Burger, CT Lemke, ...
Nature genetics 53 (12), 1664-1672, 2021
862021
Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
CA Nichols, WJ Gibson, MS Brown, JA Kosmicki, JP Busanovich, H Wei, ...
Nature communications 11 (1), 2517, 2020
842020
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
BR Paolella, WJ Gibson, LM Urbanski, JA Alberta, TI Zack, ...
Elife 6, e23268, 2017
792017
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
ZJ Reitman, BR Paolella, G Bergthold, K Pelton, S Becker, R Jones, ...
Nature communications 10 (1), 3731, 2019
582019
Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis
MC Havrda, BT Harris, A Mantani, NM Ward, BR Paolella, VC Cuzon, ...
Journal of Neuroscience 28 (52), 14074-14087, 2008
562008
p53 Directly Represses Id2 to Inhibit the Proliferation of Neural Progenitor Cells
BR Paolella, MC Havrda, A Mantani, CM Wray, Z Zhang, MA Israel
Stem cells 29 (7), 1090-1101, 2011
522011
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
P Bandopadhayay, F Piccioni, R O’Rourke, P Ho, EM Gonzalez, ...
Nature communications 10 (1), 2400, 2019
482019
Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype
G Bergthold, P Bandopadhayay, Y Hoshida, S Ramkissoon, ...
Neuro-oncology 17 (11), 1486-1496, 2015
392015
Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment
MC Havrda, BR Paolella, C Ran, KS Jering, CM Wray, JM Sullivan, ...
Cancer research 74 (6), 1822-1832, 2014
392014
Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer
DP Bondeson, BR Paolella, A Asfaw, MV Rothberg, TA Skipper, ...
Nature cancer 3 (6), 681-695, 2022
322022
Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q
JE Neggers, BR Paolella, A Asfaw, MV Rothberg, TA Skipper, A Yang, ...
Cell reports 33 (11), 2020
312020
Phosphorylation regulates Id2 degradation and mediates the proliferation of neural precursor cells
JM Sullivan, MC Havrda, AN Kettenbach, BR Paolella, Z Zhang, ...
Stem Cells 34 (5), 1321-1331, 2016
302016
Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
CF Malone, NV Dharia, G Kugener, AB Forman, MV Rothberg, ...
Cancer discovery 11 (9), 2282-2299, 2021
272021
Systematic profiling of conditional degron tag technologies for target validation studies
DP Bondeson, Z Mullin-Bernstein, S Oliver, TA Skipper, TC Atack, N Bick, ...
Nature communications 13 (1), 5495, 2022
162022
Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal
JM Krill-Burger, JM Dempster, AA Borah, BR Paolella, DE Root, TR Golub, ...
Genome Biology 24 (1), 192, 2023
152023
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