| Sonication of proteins causes formation of aggregates that resemble amyloid PB Stathopulos, GA Scholz, YM Hwang, JAO Rumfeldt, JR Lepock, ... Protein Science 13 (11), 3017-3027, 2004 | 474 | 2004 |
| Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro PB Stathopulos, JAO Rumfeldt, GA Scholz, RA Irani, HE Frey, ... Proceedings of the National Academy of Sciences 100 (12), 7021-7026, 2003 | 320 | 2003 |
| Effect of active site residues in barnase on activity and stability EM Meiering, L Serrano, AR Fersht Journal of molecular biology 225 (3), 585-589, 1992 | 272 | 1992 |
| Conformational stability and folding mechanisms of dimeric proteins JAO Rumfeldt, C Galvagnion, KA Vassall, EM Meiering Progress in biophysics and molecular biology 98 (1), 61-84, 2008 | 126 | 2008 |
| Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS KA Vassall, HR Stubbs, HA Primmer, MS Tong, SM Sullivan, R Sobering, ... Proceedings of the National Academy of Sciences 108 (6), 2210-2215, 2011 | 123 | 2011 |
| Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways A Sekhar, JAO Rumfeldt, HR Broom, CM Doyle, G Bouvignies, ... elife 4, e07296, 2015 | 116 | 2015 |
| Computational tools help improve protein stability but with a solubility tradeoff A Broom, Z Jacobi, K Trainor, EM Meiering Journal of Biological Chemistry 292 (35), 14349-14361, 2017 | 109 | 2017 |
| Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein A Broom, AC Doxey, YD Lobsanov, LG Berthin, DR Rose, PL Howell, ... Structure 20 (1), 161-171, 2012 | 109 | 2012 |
| The folding of an enzyme: V. solH2H exchange-nuclear magnetic resonance studies on the folding pathway of barnase: Complementarity to and agreement with protein engineering studies A Matouschek, L Serrano, EM Meiering, M Bycroft, AR Fersht Journal of molecular biology 224 (3), 837-845, 1992 | 108 | 1992 |
| Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase PB Stathopulos, JAO Rumfeldt, F Karbassi, CA Siddall, JR Lepock, ... Journal of biological chemistry 281 (10), 6184-6193, 2006 | 97 | 2006 |
| Mechanism and thermodynamics of guanidinium chloride-induced denaturation of ALS-associated mutant Cu, Zn superoxide dismutases JAO Rumfeldt, PB Stathopulos, A Chakrabarrty, JR Lepock, EM Meiering Journal of molecular biology 355 (1), 106-123, 2006 | 97 | 2006 |
| ALS-linked misfolded SOD1 species have divergent impacts on mitochondria S Pickles, S Semmler, HR Broom, L Destroismaisons, L Legroux, ... Acta neuropathologica communications 4, 1-14, 2016 | 93 | 2016 |
| Equilibrium Thermodynamic Analysis of Amyotrophic Lateral Sclerosis-Associated Mutant Apo Cu,Zn Superoxide Dismutases, KA Vassall, PB Stathopulos, JAO Rumfeldt, JR Lepock, EM Meiering Biochemistry 45 (23), 7366-7379, 2006 | 76 | 2006 |
| Unfolding and folding kinetics of amyotrophic lateral sclerosis-associated mutant Cu, Zn superoxide dismutases JAO Rumfeldt, JR Lepock, EM Meiering Journal of molecular biology 385 (1), 278-298, 2009 | 74 | 2009 |
| Exploring the relationships between protein sequence, structure and solubility K Trainor, A Broom, EM Meiering Current opinion in structural biology 42, 136-146, 2017 | 72 | 2017 |
| Effects of maturation on the conformational free-energy landscape of SOD1 RM Culik, A Sekhar, J Nagesh, H Deol, JAO Rumfeldt, EM Meiering, ... Proceedings of the National Academy of Sciences 115 (11), E2546-E2555, 2018 | 67 | 2018 |
| Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy A Sekhar, JAO Rumfeldt, HR Broom, CM Doyle, RE Sobering, ... Proceedings of the National Academy of Sciences 113 (45), E6939-E6945, 2016 | 66 | 2016 |
| Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis YM Hwang, PB Stathopulos, K Dimmick, H Yang, HR Badiei, MS Tong, ... Journal of biological chemistry 285 (53), 41701-41711, 2010 | 63 | 2010 |
| Energetics of oligomeric protein folding and association CM Doyle, JA Rumfeldt, HR Broom, A Broom, PB Stathopulos, KA Vassall, ... Archives of biochemistry and biophysics 531 (1-2), 44-64, 2013 | 62 | 2013 |
| Mapping transition states of protein unfolding by protein engineering of ligand-binding sites J Sancho, EM Meiering, AR Fersht Journal of molecular biology 221 (3), 1007-1014, 1991 | 61 | 1991 |
