The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism MG Iadanza, R Silvers, J Boardman, HI Smith, TK Karamanos, ... Nature Communications 9 (1), 4517, 2018 | 133 | 2018 |
Mechanisms of amyloid formation revealed by solution NMR TK Karamanos, AP Kalverda, GS Thompson, SE Radford Progress in nuclear magnetic resonance spectroscopy 88, 86-104, 2015 | 127 | 2015 |
pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers KW Tipping, TK Karamanos, T Jakhria, MG Iadanza, SC Goodchild, ... Proceedings of the National Academy of Sciences 112 (18), 5691-5696, 2015 | 124 | 2015 |
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo CL Dobson, PWA Devine, JJ Phillips, DR Higazi, C Lloyd, B Popovic, ... Scientific reports 6 (1), 1-14, 2016 | 120 | 2016 |
Visualizing and trapping transient oligomers in amyloid assembly pathways EE Cawood, TK Karamanos, AJ Wilson, SE Radford Biophysical chemistry 268, 106505, 2021 | 108 | 2021 |
Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis TK Karamanos, V Tugarinov, GM Clore Proceedings of the National Academy of Sciences 116 (43), 21529-21538, 2019 | 72 | 2019 |
Visualization of transient protein-protein interactions that promote or inhibit amyloid assembly TK Karamanos, AP Kalverda, GS Thompson, SE Radford Molecular cell 55 (2), 214-226, 2014 | 66 | 2014 |
Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients AN Calabrese, B Schiffrin, M Watson, TK Karamanos, M Walko, ... Nature Communications 11 (1), 1-16, 2020 | 59 | 2020 |
Structural mapping of oligomeric intermediates in an amyloid assembly pathway TK Karamanos, MP Jackson, AN Calabrese, SC Goodchild, EE Cawood, ... Elife 8, e46574, 2019 | 53 | 2019 |
A population shift between sparsely populated folding intermediates determines amyloidogenicity TK Karamanos, CL Pashley, AP Kalverda, GS Thompson, M Mayzel, ... Journal of the American Chemical Society 138 (19), 6271-6280, 2016 | 39 | 2016 |
An S/T motif controls reversible oligomerization of the Hsp40 chaperone DNAJB6b through subtle reorganization of a β sheet backbone TK Karamanos, V Tugarinov, GM Clore Proceedings of the National Academy of Sciences 117 (48), 30441-30450, 2020 | 27 | 2020 |
Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins EM Martin, MP Jackson, M Gamerdinger, K Gense, TK Karamonos, ... Journal of Biological Chemistry 293 (22), 8554-8568, 2018 | 24 | 2018 |
Modulation of amyloidogenic protein self-assembly using tethered small molecules EE Cawood, N Guthertz, JS Ebo, TK Karamanos, SE Radford, AJ Wilson Journal of the American Chemical Society 142 (49), 20845-20854, 2020 | 22 | 2020 |
Extracellular matrix components modulate different stages in β2-microglobulin amyloid formation N Benseny-Cases, TK Karamanos, CL Hoop, J Baum, SE Radford Journal of Biological Chemistry 294 (24), 9392-9401, 2019 | 22 | 2019 |
Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding B Schiffrin, JM Machin, TK Karamanos, A Zhuravleva, DJ Brockwell, ... Communications Biology 5 (1), 560, 2022 | 20 | 2022 |
Structural studies of “aggregation‐prone” peptide‐analogues of teleostean egg chorion ZPB proteins NN Louros, N Petronikolou, T Karamanos, P Cordopatis, VA Iconomidou, ... Peptide Science 102 (6), 427-436, 2014 | 18 | 2014 |
Magic‐Angle‐Pulse Driven Separation of Degenerate 1H Transitions in Methyl Groups of Proteins: Application to Studies of Methyl Axis Dynamics V Tugarinov, TK Karamanos, GM Clore ChemPhysChem 21 (11), 1087-1091, 2020 | 15 | 2020 |
Microsecond backbone motions modulate the oligomerization of the Dnajb6 chaperone EE Cawood, GM Clore, TK Karamanos Angewandte Chemie 134 (20), e202116403, 2022 | 14 | 2022 |
Optimized selection of slow-relaxing 13 C transitions in methyl groups of proteins: application to relaxation dispersion V Tugarinov, TK Karamanos, GM Clore Journal of Biomolecular NMR 74 (12), 673-680, 2020 | 12 | 2020 |
Optimized NMR Experiments for the Isolation of I=1/2 Manifold Transitions in Methyl Groups of Proteins V Tugarinov, TK Karamanos, A Ceccon, GM Clore ChemPhysChem 21 (1), 13-19, 2020 | 12 | 2020 |