Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs CJH Porter, NL Trevaskis, WN Charman Nature reviews Drug discovery 6 (3), 231-248, 2007 | 1993 | 2007 |
Strategies to address low drug solubility in discovery and development HD Williams, NL Trevaskis, SA Charman, RM Shanker, WN Charman, ... Pharmacological reviews 65 (1), 315-499, 2013 | 1685 | 2013 |
Enhancing intestinal drug solubilisation using lipid-based delivery systems CJH Porter, CW Pouton, JF Cuine, WN Charman Advanced drug delivery reviews 60 (6), 673-691, 2008 | 843 | 2008 |
Lipid-based vehicles for the oral delivery of poorly water soluble drugs AJ Humberstone, WN Charman Advanced drug delivery reviews 25 (1), 103-128, 1997 | 812 | 1997 |
Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH WN Charman, CJH Porter, S Mithani, JB Dressman Journal of pharmaceutical sciences 86 (3), 269-282, 1997 | 782 | 1997 |
Identification of an antimalarial synthetic trioxolane drug development candidate JL Vennerstrom, S Arbe-Barnes, R Brun, SA Charman, FCK Chiu, ... Nature 430 (7002), 900-904, 2004 | 781 | 2004 |
Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound SA Charman, WN Charman, MC Rogge, TD Wilson, FJ Dutko, CW Pouton Pharmaceutical research 9, 87-93, 1992 | 631 | 1992 |
Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine SM Khoo, AJ Humberstone, CJH Porter, GA Edwards, WN Charman International journal of pharmaceutics 167 (1-2), 155-164, 1998 | 564 | 1998 |
In vitro assessment of oral lipid based formulations CJH Porter, WN Charman Advanced drug delivery reviews 50, S127-S147, 2001 | 498 | 2001 |
Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update NL Trevaskis, WN Charman, CJH Porter Advanced drug delivery reviews 60 (6), 702-716, 2008 | 470 | 2008 |
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria SA Charman, S Arbe-Barnes, IC Bathurst, R Brun, M Campbell, ... Proceedings of the National Academy of Sciences 108 (11), 4400-4405, 2011 | 449 | 2011 |
Intestinal lymphatic drug transport: an update CJH Porter, WN Charman Advanced drug delivery reviews 50 (1-2), 61-80, 2001 | 405 | 2001 |
Lipids, lipophilic drugs, and oral drug delivery—some emerging concepts WN Charman Journal of pharmaceutical sciences 89 (8), 967-978, 2000 | 387 | 2000 |
50 years of oral lipid-based formulations: provenance, progress and future perspectives OM Feeney, MF Crum, CL McEvoy, NL Trevaskis, HD Williams, ... Advanced drug delivery reviews 101, 167-194, 2016 | 381 | 2016 |
Prodrugs: Do they have advantages in clinical practice? VJ Stella, WNA Charman, VH Naringrekar Drugs 29, 455-473, 1985 | 361 | 1985 |
Effect of short‐, medium‐, and long‐chain fatty acid‐based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of … SM Caliph, WN Charman, CJH Porter Journal of pharmaceutical sciences 89 (8), 1073-1084, 2000 | 349 | 2000 |
Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products L Sek, CJH Porter, AM Kaukonen, WN Charman Journal of pharmacy and pharmacology 54 (1), 29-41, 2002 | 344 | 2002 |
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors … JM Coteron, M Marco, J Esquivias, X Deng, KL White, J White, M Koltun, ... Journal of medicinal chemistry 54 (15), 5540-5561, 2011 | 322 | 2011 |
The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? MM Doherty, WN Charman Clinical pharmacokinetics 41, 235-253, 2002 | 303 | 2002 |
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice R Gujjar, A Marwaha, F El Mazouni, J White, KL White, S Creason, ... Journal of medicinal chemistry 52 (7), 1864-1872, 2009 | 292 | 2009 |