β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities CS Casley, L Canevari, JM Land, JB Clark, MA Sharpe Journal of neurochemistry 80 (1), 91-100, 2002 | 600 | 2002 |
β-Amyloid fragment 25–35 causes mitochondrial dysfunction in primary cortical neurons CS Casley, JM Land, MA Sharpe, JB Clark, MR Duchen, L Canevari Neurobiology of disease 10 (3), 258-267, 2002 | 252 | 2002 |
Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite MA Sharpe, CE Cooper Biochemical Journal 332 (1), 9-19, 1998 | 245 | 1998 |
Oxidation of nitric oxide by oxomanganese–salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics MA Sharpe, R Ollosson, VC Stewart, JB Clark Biochemical Journal 366 (1), 97-107, 2002 | 198 | 2002 |
Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans M Keaney, F Matthijssens, M Sharpe, J Vanfleteren, D Gems Free Radical Biology and Medicine 37 (2), 239-250, 2004 | 196 | 2004 |
Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase: Catalytic Production of Nitric Oxide and Irreversible Inhibition of Enzyme Activity MA Sharpe, CE Cooper Journal of Biological Chemistry 273 (47), 30961-30972, 1998 | 183 | 1998 |
Astrocyte‐derived nitric oxide causes both reversible and irreversible damage to the neuronal mitochondrial respiratory chain VC Stewart, MA Sharpe, JB Clark, SJR Heales Journal of neurochemistry 75 (2), 694-700, 2000 | 175 | 2000 |
Fibrillar beta-amyloid peptide Aβ1–40 activates microglial proliferation via stimulating TNF-α release and H2O2 derived from NADPH oxidase: a cell culture study A Jekabsone, PK Mander, A Tickler, M Sharpe, GC Brown Journal of neuroinflammation 3, 1-13, 2006 | 166 | 2006 |
Regulation of the pentose phosphate pathway by an androgen receptor–mTOR-mediated mechanism and its role in prostate cancer cell growth E Tsouko, AS Khan, MA White, JJ Han, Y Shi, FA Merchant, MA Sharpe, ... Oncogenesis 3 (5), e103-e103, 2014 | 165 | 2014 |
Cytochrome c oxidase rapidly metabolises nitric oxide to nitrite J Torres, MA Sharpe, A Rosquist, CE Cooper, MT Wilson FEBS letters 475 (3), 263-266, 2000 | 130 | 2000 |
Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins … CE Cooper, J Torres, MA Sharpe, MT Wilson FEBS letters 414 (2), 281-284, 1997 | 123 | 1997 |
Toxicity of myoglobin and haemoglobin: oxidative stress in patients with rhabdomyolysis and subarachnoid haemorrhage BJ Reeder, MA Sharpe, AD Kay, M Kerr, K Moore, MT Wilson Biochemical Society Transactions 30 (4), 745-748, 2002 | 121 | 2002 |
Characteristics and mechanism of formation of peroxide-induced heme to protein cross-linking in myoglobin BJ Reeder, DA Svistunenko, MA Sharpe, MT Wilson Biochemistry 41 (1), 367-375, 2002 | 100 | 2002 |
Nitric oxide and peroxynitrite cause irreversible increases in the Km for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies CE Cooper, NA Davies, M Psychoulis, L Canevari, TE Bates, MS Dobbie, ... Biochimica et Biophysica Acta (BBA)-Bioenergetics 1607 (1), 27-34, 2003 | 98 | 2003 |
Storage of an Excess Proton in the Hydrogen-Bonded Network of the D-Pathway of Cytochrome c Oxidase: Identification of a Protonated Water Cluster J Xu, MA Sharpe, L Qin, S Ferguson-Miller, GA Voth Journal of the American Chemical Society 129 (10), 2910-2913, 2007 | 93 | 2007 |
Nitric oxide and Fenton/Haber–Weiss chemistry: nitric oxide is a potent antioxidant at physiological concentrations MA Sharpe, SJ Robb, JB Clark Journal of neurochemistry 87 (2), 386-394, 2003 | 86 | 2003 |
Lipotoxicity in renal proximal tubular cells: relationship between endoplasmic reticulum stress and oxidative stress pathways E Katsoulieris, JG Mabley, M Samai, MA Sharpe, IC Green, PK Chatterjee Free Radical Biology and Medicine 48 (12), 1654-1662, 2010 | 84 | 2010 |
A chemically explicit model for the mechanism of proton pumping in heme–copper oxidases MA Sharpe, S Ferguson-Miller Journal of bioenergetics and biomembranes 40, 541-549, 2008 | 84 | 2008 |
Superoxide dismutase mimetics with catalase activity reduce the organ injury in hemorrhagic shock M Izumi, MC McDonald, MA Sharpe, PK Chatterjee, C Thiemermann Shock 18 (3), 230-235, 2002 | 79 | 2002 |
Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease R Clayton, JB Clark, M Sharpe Journal of neurochemistry 92 (4), 840-849, 2005 | 78 | 2005 |