Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ... Frontiers in Neuroscience, 541, 2021 | 43 | 2021 |
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, ... Communications Chemistry 3 (1), 1-9, 2020 | 36 | 2020 |
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates R Bell, RJ Thrush, M Castellana-Cruz, M Oeller, R Staats, A Nene, ... Biochemistry, 2022 | 31 | 2022 |
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates S Chia, ZF Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, ... bioRxiv, 2021 | 27 | 2021 |
The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity KJ Mostert, N Sharma, M van der Zwaag, R Staats, L Koekemoer, ... ACS Chemical Biology, 2021 | 9 | 2021 |
A Machine Learning Approach to Identify Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation RI Horne, A Possenti, S Chia, ZF Brotzakis, R Staats, M Nowinska, ... bioRxiv, 2021 | 6 | 2021 |
Systematic Development of Small Molecules to Inhibit Specific Steps of α-Synuclein Aggregation in Parkinson's Disease R Staats, P Flagmeier, M Vendruscolo Biophysical Journal 114 (3), 77a, 2018 | 1 | 2018 |
Therapeutic drug targeting in Alzheimer's disease R Geiser, M Sanguanini, R Staats, D Rinauro, M Metrick, P Ciryam, ... Biophysical Journal 121 (3), 190a, 2022 | | 2022 |