| The art of CHO cell engineering: A comprehensive retrospect and future perspectives S Fischer, R Handrick, K Otte Biotechnology advances 33 (8), 1878-1896, 2015 | 365 | 2015 |
| Identification of farnesoid X receptor β as a novel mammalian nuclear receptor sensing lanosterol K Otte, H Kranz, I Kober, P Thompson, M Hoefer, B Haubold, B Remmel, ... Molecular and cellular biology 23 (3), 864-872, 2003 | 204 | 2003 |
| MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells M Kleemann, H Schneider, K Unger, P Sander, EM Schneider, ... Scientific reports 8 (1), 9020, 2018 | 102 | 2018 |
| Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation S Fischer, R Handrick, A Aschrafi, K Otte RNA biology 12 (3), 238-247, 2015 | 83 | 2015 |
| A functional high‐content miRNA screen identifies miR‐30 family to boost recombinant protein production in CHO cells S Fischer, T Buck, A Wagner, C Ehrhart, J Giancaterino, S Mang, M Schad, ... Biotechnology journal 9 (10), 1279-1292, 2014 | 78 | 2014 |
| Transcriptional regulation and biological significance of the insulin like growth factor II gene W Engström, A Shokrai, K Otte, M Granerus, A Gessbo, P Bierke, A Madej, ... Cell proliferation 31 (5-6), 173-189, 1998 | 78 | 1998 |
| miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells M Flum, M Kleemann, H Schneider, B Weis, S Fischer, R Handrick, K Otte Journal of cell communication and signaling 12, 451-466, 2018 | 62 | 2018 |
| miR‐2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality S Fischer, AJ Paul, A Wagner, S Mathias, M Geiss, F Schandock, ... Biotechnology and bioengineering 112 (10), 2142-2153, 2015 | 55 | 2015 |
| GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells A Schrade, A Kyrönlahti, O Akinrinade, M Pihlajoki, S Fischer, ... Endocrinology 157 (6), 2416-2431, 2016 | 52 | 2016 |
| FXR NR1H4 nuclear receptor binding compounds U Bauer, Z Cheruvallath, U Deuschle, E Dneprovskaia, T Gahman, ... US Patent 7,098,336, 2006 | 51 | 2006 |
| Breaking limitations of complex culture media: functional non-viral miRNA delivery into pharmaceutical production cell lines S Fischer, A Wagner, A Kos, A Aschrafi, R Handrick, J Hannemann, K Otte Journal of biotechnology 168 (4), 589-600, 2013 | 47 | 2013 |
| CRISPR/Cas9‐mediated knockout of microRNA‐744 improves antibody titer of CHO production cell lines N Raab, S Mathias, K Alt, R Handrick, S Fischer, V Schmieder, V Jadhav, ... Biotechnology Journal 14 (5), 1800477, 2019 | 46 | 2019 |
| Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD S Mathias, A Wippermann, N Raab, N Zeh, R Handrick, I Gorr, P Schulz, ... Biotechnology and Bioengineering 117 (1), 5-16, 2020 | 41 | 2020 |
| Enhanced protein production by microRNA-30 family in CHO cells is mediated by the modulation of the ubiquitin pathway S Fischer, S Mathias, S Schaz, VV Emmerling, T Buck, M Kleemann, ... Journal of biotechnology 212, 32-43, 2015 | 41 | 2015 |
| Temperature‐sensitive miR‐483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells VV Emmerling, S Fischer, F Stiefel, K Holzmann, R Handrick, F Hesse, ... Biotechnology and bioengineering 113 (4), 830-841, 2016 | 40 | 2016 |
| Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy S Mathias, S Fischer, R Handrick, J Fieder, P Schulz, H Bradl, I Gorr, ... Journal of biotechnology 271, 47-55, 2018 | 37 | 2018 |
| Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5 M Kleemann, H Schneider, K Unger, J Bereuther, S Fischer, P Sander, ... Cellular and Molecular Life Sciences 76, 539-559, 2019 | 36 | 2019 |
| FISH mapping of the IGF2 gene in horse and donkey—detection of homoeology with HSA11 T Raudsepp, K Otte, B Rozell, BP Chowdhary Mammalian genome 8, 569-572, 1997 | 34 | 1997 |
| miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering F Stiefel, S Fischer, A Sczyrba, K Otte, F Hesse Journal of Biotechnology 225, 31-43, 2016 | 29 | 2016 |
| NR1H4 nuclear receptor binding compounds U Bauer, Z Cheruvallath, U Deuschle, E Dneprovskaia, T Gahman, ... US Patent 6,974,830, 2005 | 29 | 2005 |
