Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection FP Theil, TW Guentert, S Haddad, P Poulin Toxicology letters 138 (1-2), 29-49, 2003 | 239 | 2003 |
A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures S Haddad, M Béliveau, R Tardif, K Krishnan Toxicological sciences 63 (1), 125-131, 2001 | 144 | 2001 |
Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons S Haddad, R Tardif, G Charest-Tardif, K Krishnan Toxicology and applied pharmacology 161 (3), 249-257, 1999 | 138 | 1999 |
Relative lipid content as the sole mechanistic determinant of the adipose tissue: blood partition coefficients of highly lipophilic organic chemicals S Haddad, P Poulin, K Krishnan Chemosphere 40 (8), 839-843, 2000 | 133 | 2000 |
Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children K Price, S Haddad, K Krishnan Journal of Toxicology and Environmental Health Part A 66 (5), 417-433, 2003 | 127 | 2003 |
Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans S Haddad, C Restieri, K Krishnan Journal of Toxicology and Environmental Health Part A 64 (6), 453-464, 2001 | 125 | 2001 |
In vitro–in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods P Poulin, JR Kenny, CECA Hop, S Haddad Journal of pharmaceutical sciences 101 (2), 838-851, 2012 | 116 | 2012 |
A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies MA Verner, P Ayotte, G Muckle, M Charbonneau, S Haddad Environmental health perspectives 117 (3), 481-487, 2009 | 111 | 2009 |
Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies MA Verner, M Charbonneau, L López-Carrillo, S Haddad Environmental health perspectives 116 (7), 886-892, 2008 | 105 | 2008 |
Toxicokinetics of titanium dioxide (TiO2) nanoparticles after inhalation in rats I Pujalté, D Dieme, S Haddad, AM Serventi, M Bouchard Toxicology letters 265, 77-85, 2017 | 104 | 2017 |
Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures S Haddad, G Charest-Tardif, R Tardif, K Krishnan Toxicology and applied pharmacology 167 (3), 199-209, 2000 | 102 | 2000 |
Physiological modeling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures. K Krishnan, S Haddad, M Béliveau, R Tardif Environmental Health Perspectives 110 (suppl 6), 989-994, 2002 | 93 | 2002 |
Assessment of air and water contamination by disinfection by-products at 41 indoor swimming pools R Tardif, C Catto, S Haddad, S Simard, M Rodriguez Environmental Research 148, 411-420, 2016 | 88 | 2016 |
Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes S Haddad, GC Tardif, R Tardif Journal of Toxicology and Environmental Health, Part A 69 (23), 2095-2136, 2006 | 87 | 2006 |
Physiologically-Based Pharmacokinetic (PBPK) Models in Toxicity Testing and Risk Assessment JC Lipscomb, S Haddad, T Poet, K Krishnan New Technologies for Toxicity Testing, 76-95, 2012 | 79 | 2012 |
The role of extracellular binding proteins in the cellular uptake of drugs: impact on quantitative in vitro-to-in vivo extrapolations of toxicity and efficacy in … P Poulin, FJ Burczynski, S Haddad Journal of pharmaceutical sciences 105 (2), 497-508, 2016 | 77 | 2016 |
Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children M Gascon, MA Verner, M Guxens, JO Grimalt, J Forns, J Ibarluzea, ... Neurotoxicology 34, 9-15, 2013 | 75 | 2013 |
Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue‐composition‐based model as a mechanistic animal … P Poulin, S Haddad Journal of pharmaceutical sciences 101 (6), 2250-2261, 2012 | 73 | 2012 |
Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies MA Verner, D Sonneborn, K Lancz, G Muckle, P Ayotte, É Dewailly, ... Environ Health Perspect 121 (1), 131-137, 2013 | 69 | 2013 |
Comparative assessment of In Vitro–In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs P Poulin, CECA Hop, Q Ho, JS Halladay, S Haddad, JR Kenny Journal of pharmaceutical sciences 101 (11), 4308-4326, 2012 | 64 | 2012 |