Design, multigram synthesis, and in vitro and in vivo evaluation of propylamycin: a semisynthetic 4, 5-deoxystreptamine class aminoglycoside for the treatment of drug-resistant … T Matsushita, GC Sati, N Kondasinghe, MG Pirrone, T Kato, P Waduge, ... Journal of the American Chemical Society 141 (12), 5051-5061, 2019 | 56 | 2019 |
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity A Sonousi, JCK Quirke, P Waduge, T Janusic, M Gysin, K Haldimann, ... ChemMedChem 16 (2), 335-339, 2021 | 20 | 2021 |
Chemical probing for examining the structure of modified RNAs and ligand binding to RNA P Waduge, Y Sakakibara, CS Chow Methods 156, 110-120, 2019 | 18 | 2019 |
Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy C Dai, P Waduge, L Ji, C Huang, Y He, H Tian, E Zuniga-Sanchez, ... Cellular and Molecular Life Sciences 79 (1), 63, 2022 | 12 | 2022 |
Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization L Ji, P Waduge, L Hao, A Kaur, W Wan, Y Wu, H Tian, J Zhang, ... FASEB journal: official publication of the Federation of American Societies …, 2022 | 10 | 2022 |
Comparative ligandomics implicates secretogranin III as a disease‐restricted angiogenic factor in laser‐induced choroidal neovascularization L Ji, P Waduge, W Wan, H Tian, J Li, J Zhang, R Chen, W Li The FEBS journal 289 (12), 3521-3534, 2022 | 8 | 2022 |
Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites P Waduge, GC Sati, D Crich, CS Chow Bioorganic & medicinal chemistry 27 (22), 115121, 2019 | 6 | 2019 |
Secretogranin III selectively promotes vascular leakage in the deep vascular plexus of diabetic retinopathy L Ji, P Waduge, Y Wu, C Huang, A Kaur, P Oliveira, H Tian, J Zhang, ... International Journal of Molecular Sciences 24 (13), 10531, 2023 | 4 | 2023 |
Profiling disease-selective drug targets: From proteomics to ligandomics P Waduge, H Tian, KA Webster, W Li Drug discovery today 28 (3), 103430, 2023 | 4 | 2023 |
Anti-Scg3 Gene Therapy to Treat Choroidal Neovascularization in Mice C Huang, L Ji, A Kaur, H Tian, P Waduge, KA Webster, W Li Biomedicines 11 (7), 1910, 2023 | 3 | 2023 |
A method for rapid and reliable quantification of VEGF-cell binding activity P Waduge, A Kaur, W Li Biochemical and Biophysical Research Communications 727, 150321, 2024 | | 2024 |
Optimal Humanized Scg3-Neutralizing Antibodies for Anti-Angiogenic Therapy of Diabetic Retinopathy C Huang, P Waduge, A Kaur, H Tian, CY Weng, JT Stout, IH Pang, ... International Journal of Molecular Sciences 25 (17), 9507, 2024 | | 2024 |
A rapid and convenient method to quantify VEGF binding to cells P Waduge, A Kaur, W Li Investigative Ophthalmology & Visual Science 65 (7), 1928-1928, 2024 | | 2024 |
Ex vivo ligandomics to profile diabetic vs. healthy retinal cells for drug target discovery W Li, P Waduge, C Huang, Y Li, J Li Investigative Ophthalmology & Visual Science 65 (7), 317-317, 2024 | | 2024 |
Anti-Scg3 therapy of oxygen-induced retinopathy in a canine model B Zhang, C Huang, GJ Louise, D Jackson, P Waduge, RA Veettil, X Lin, ... Investigative Ophthalmology & Visual Science 65 (7), 296-296, 2024 | | 2024 |
Generation of optimal humanized Scg3-neutralizing antibodies for anti-angiogenic therapy C Huang, A Kaur, P Waduge, CY Weng, H Tian, W Li Investigative Ophthalmology & Visual Science 65 (7), 6115-6115, 2024 | | 2024 |
Exploiting retinal endothelial heterogeneity for disease-targeted therapy of diabetic retinopathy P Waduge, L Ji, Y Wu, C Huang, A Kaur, P Oliveira, H Tian, J Zhang, ... Investigative Ophthalmology & Visual Science 64 (8), 997-997, 2023 | | 2023 |
Ligandomics: A new technology to globally map disease-selective angiogenic factors for ocular therapeutics W Li, P Waduge, H Tian, KA Webster Investigative Ophthalmology & Visual Science 64 (8), 1868-1868, 2023 | | 2023 |
Exploring the Binding of Aminoglycosides and Effect of Peptides on Functionally Important Regions of the Ribosome PMD Waduge Wayne State University, 2019 | | 2019 |