How neutrophils kill microbes AW Segal Annu. Rev. Immunol. 23, 197-223, 2005 | 2405 | 2005 |
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor EO Glocker, D Kotlarz, K Boztug, EM Gertz, AA Schäffer, F Noyan, M Perro, ... New England Journal of Medicine 361 (21), 2033-2045, 2009 | 1671 | 2009 |
Killing activity of neutrophils is mediated through activation of proteases by K+ flux EP Reeves, H Lu, HL Jacobs, CGM Messina, S Bolsover, G Gabella, ... Nature 416 (6878), 291-297, 2002 | 1418 | 2002 |
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1 A Abo, E Pick, A Hall, N Totty, CG Teahan, AW Segal Nature 353 (6345), 668-670, 1991 | 1200 | 1991 |
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency F Altare, A Durandy, D Lammas, JF Emile, S Lamhamedi, F Le Deist, ... Science 280 (5368), 1432-1435, 1998 | 1067 | 1998 |
The biochemical basis of the NADPH oxidase of phagocytes AW Segal, A Abo Trends in biochemical sciences 18 (2), 43-47, 1993 | 799 | 1993 |
The NADPH oxidase of professional phagocytes—prototype of the NOX electron transport chain systems AR Cross, AW Segal Biochimica et Biophysica Acta (BBA)-Bioenergetics 1657 (1), 1-22, 2004 | 611 | 2004 |
Elemental diet as primary treatment of acute Crohn's disease: a controlled trial. C O'moráin, AW Segal, AJ Levi Br Med J (Clin Res Ed) 288 (6434), 1859-1862, 1984 | 574 | 1984 |
Interaction of Rac with p67phox and Regulation pf Phagocytic NADPH Oxidase Activity D Diekmann, A Abo, C Johnston, AW Segal, A Hall Science 265 (5171), 531-533, 1994 | 531 | 1994 |
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease AM Smith, FZ Rahman, BH Hayee, SJ Graham, DJB Marks, GW Sewell, ... Journal of Experimental Medicine 206 (9), 1883-1897, 2009 | 519 | 2009 |
Defective acute inflammation in Crohn's disease: a clinical investigation DJB Marks, MWN Harbord, R MacAllister, FZ Rahman, J Young, ... The Lancet 367 (9511), 668-678, 2006 | 518 | 2006 |
Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease D Roos, M de Boer, F Kuribayashi, C Meischl, RS Weening, AW Segal, ... | 493 | 1996 |
The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH AW Segal, M Geisow, R Garcia, A Harper, R Miller Nature 290 (5805), 406-409, 1981 | 488 | 1981 |
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G J Tkalcevic, M Novelli, M Phylactides, JP Iredale, AW Segal, J Roes Immunity 12 (2), 201-210, 2000 | 472 | 2000 |
Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. KH In, K Asano, D Beier, J Grobholz, PW Finn, EK Silverman, ... The Journal of clinical investigation 99 (5), 1130-1137, 1997 | 462 | 1997 |
Indium-111-labeled autologous leukocytes in man ML Thakur, JP Lavender, RN Arnot, DJ Silvester, AW Segal Journal of Nuclear medicine 18 (10), 1014-1021, 1977 | 459 | 1977 |
Novel cytochrome b system in phagocytic vacuoles of human granulocytes AW Segal, OTG JONES Nature 276 (5687), 515-517, 1978 | 453 | 1978 |
Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes AW Segal, I West, F Wientjes, JHA Nugent, AJ Chavan, B Haley, ... Biochemical Journal 284 (3), 781-788, 1992 | 423 | 1992 |
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains FB Wientjes, JJ Hsuan, NF Totty, AW Segal Biochemical Journal 296 (3), 557-561, 1993 | 397 | 1993 |
Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease AW Segal Nature 326 (6108), 88-91, 1987 | 393 | 1987 |