| The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration K Essuman, DW Summers, Y Sasaki, X Mao, A DiAntonio, J Milbrandt Neuron 93 (6), 1334-1343. e5, 2017 | 560 | 2017 |
| Sarm1-mediated axon degeneration requires both SAM and TIR interactions J Gerdts, DW Summers, Y Sasaki, A DiAntonio, J Milbrandt Journal of Neuroscience 33 (33), 13569-13580, 2013 | 370 | 2013 |
| Axon self-destruction: new links among SARM1, MAPKs, and NAD+ metabolism J Gerdts, DW Summers, J Milbrandt, A DiAntonio Neuron 89 (3), 449-460, 2016 | 334 | 2016 |
| TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes K Essuman, DW Summers, Y Sasaki, X Mao, AKY Yim, A DiAntonio, ... Current Biology 28 (3), 421-430. e4, 2018 | 231 | 2018 |
| Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons DW Summers, A DiAntonio, J Milbrandt Journal of Neuroscience 34 (28), 9338-9350, 2014 | 182 | 2014 |
| MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2 LJ Walker, DW Summers, Y Sasaki, EJ Brace, J Milbrandt, A DiAntonio Elife 6, e22540, 2017 | 147 | 2017 |
| SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation DW Summers, DA Gibson, A DiAntonio, J Milbrandt Proceedings of the National Academy of Sciences 113 (41), E6271-E6280, 2016 | 142 | 2016 |
| Gene therapy targeting SARM1 blocks pathological axon degeneration in mice S Geisler, SX Huang, A Strickland, RA Doan, DW Summers, X Mao, ... Journal of Experimental Medicine 216 (2), 294-303, 2019 | 120 | 2019 |
| Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones DW Summers, PM Douglas, CHI Ramos, DM Cyr Trends in biochemical sciences 34 (5), 230-233, 2009 | 100 | 2009 |
| Transcription errors induce proteotoxic stress and shorten cellular lifespan M Vermulst, AS Denney, MJ Lang, CW Hung, S Moore, MA Moseley, ... Nature communications 6 (1), 8065, 2015 | 99 | 2015 |
| The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein DW Summers, KJ Wolfe, HY Ren, DM Cyr PloS one 8 (1), e52099, 2013 | 98 | 2013 |
| Palmitoylation enables MAPK-dependent proteostasis of axon survival factors DW Summers, J Milbrandt, A DiAntonio Proceedings of the National Academy of Sciences 115 (37), E8746-E8754, 2018 | 71 | 2018 |
| DLK activation synergizes with mitochondrial dysfunction to downregulate axon survival factors and promote SARM1-dependent axon degeneration DW Summers, E Frey, LJ Walker, J Milbrandt, A DiAntonio Molecular Neurobiology 57, 1146-1158, 2020 | 62 | 2020 |
| Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways PM Douglas, DW Summers, DM Cyr Prion 3 (2), 51-58, 2009 | 61 | 2009 |
| Identification of a consensus motif in substrates bound by a Type I Hsp40 P Kota, DW Summers, HY Ren, DM Cyr, NV Dokholyan Proceedings of the National Academy of Sciences 106 (27), 11073-11078, 2009 | 52 | 2009 |
| The type I Hsp40 Ydj1 utilizes a farnesyl moiety and zinc finger-like region to suppress prion toxicity DW Summers, PM Douglas, HY Ren, DM Cyr Journal of Biological Chemistry 284 (6), 3628-3639, 2009 | 46 | 2009 |
| Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus PM Douglas, DW Summers, HY Ren, DM Cyr Molecular biology of the cell 20 (19), 4162-4173, 2009 | 37 | 2009 |
| Prion propagation by Hsp40 molecular chaperones DW Summers, PM Douglas, DM Cyr Prion 3 (2), 59-64, 2009 | 35 | 2009 |
| Use of yeast as a system to study amyloid toxicity DW Summers, DM Cyr Methods 53 (3), 226-231, 2011 | 20 | 2011 |
| The Stathmin-2 membrane targeting domain is required for axon protection and regulated degradation by DLK signaling EJC Thornburg-Suresh, JE Richardson, DW Summers Journal of Biological Chemistry, 104861, 2023 | 10 | 2023 |
