The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1− 40 peptide P Narayan, A Orte, RW Clarke, B Bolognesi, S Hook, KA Ganzinger, ... Nature Structural & Molecular Biology 19 (1), 79-83, 2011 | 303 | 2011 |
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia G Sienski, P Narayan, JM Bonner, N Kory, S Boland, AA Arczewska, ... Science translational medicine 13 (583), 2021 | 209 | 2021 |
Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity KES Matlack, DF Tardiff, P Narayan, S Hamamichi, KA Caldwell, ... Proceedings of the National Academy of Sciences 111 (11), 4013-4018, 2014 | 179 | 2014 |
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus DJ Whitcomb, EL Hogg, P Regan, T Piers, P Narayan, G Whitehead, ... Scientific reports 5, 2015 | 108 | 2015 |
Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage P Narayan, KM Holmström, DH Kim, DJ Whitcomb, MR Wilson, ... Biochemistry 53 (15), 2442-2453, 2014 | 106 | 2014 |
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells P Narayan, KA Ganzinger, J McColl, L Weimann, S Meehan, S Qamar, ... Journal of the American Chemical Society 135 (4), 1491-1498, 2013 | 94 | 2013 |
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones P Narayan, S Meehan, JA Carver, MR Wilson, CM Dobson, D Klenerman Biochemistry 51 (46), 9270-9276, 2012 | 94 | 2012 |
A reference human induced pluripotent stem cell line for large-scale collaborative studies CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendraat, L Peng, ... Cell Stem Cell 29 (12), 1685-1702. e22, 2022 | 89 | 2022 |
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, ... Scientific Reports 6, 2016 | 65 | 2016 |
Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity C Kayatekin, A Amasino, G Gaglia, J Flannick, JM Bonner, S Fanning, ... Cell, 2018 | 63 | 2018 |
PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4 P Narayan, G Sienski, JM Bonner, YT Lin, J Seo, V Baru, A Haque, B Milo, ... Cell Reports 33 (1), 108224, 2020 | 62 | 2020 |
Combating neurodegenerative disease with chemical probes and model systems P Narayan, S Ehsani, S Lindquist Nature chemical biology 10 (11), 911-920, 2014 | 53 | 2014 |
Single‐Molecule Imaging Reveals that Small Amyloid‐β1–42 Oligomers Interact with the Cellular Prion Protein (PrPC) KA Ganzinger, P Narayan, SS Qamar, L Weimann, RT Ranasinghe, ... ChemBioChem 15 (17), 2515-2521, 2014 | 50 | 2014 |
Apolipoprotein E in lipid metabolism and neurodegenerative disease LG Yang, ZM March, RA Stephenson, PS Narayan Trends in Endocrinology & Metabolism, 2023 | 29 | 2023 |
Design of DNA-conjugated polypeptide-based capture probes for the anchoring of proteins to DNA matrices RM Schweller, PE Constantinou, NW Frankel, P Narayan, MR Diehl Bioconjugate chemistry 19 (12), 2304-2307, 2008 | 27 | 2008 |
A fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline L Reilly, E Lara, D Ramos, Z Li, CB Pantazis, J Stadler, M Santiana, ... Cell Reports Methods 3 (10), 2023 | 11 | 2023 |
A fully automated FAIMS-DIA proteomic pipeline for high-throughput characterization of iPSC-derived neurons L Reilly, L Peng, E Lara, D Ramos, M Fernandopulle, CB Pantazis, ... bioRxiv, 2021.11. 24.469921, 2021 | 11 | 2021 |
Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia RA Stephenson, KR Johnson, L Cheng, LG Yang, JT Root, ... bioRxiv, 2024 | | 2024 |
Harnessing diversity to study Alzheimer’s disease: A new iPSC resource from the NIH CARD and ADNI LA Screven, CB Pantazis, KM Andersh, S Hong, D Vitale, E Lara, RY Ku, ... Neuron, 2024 | | 2024 |
Molecular Role of Lipids in Aging D Skowronska-Krawczyk, P Narayan, P Tessarz Frontiers in Aging 3, 946884, 2022 | | 2022 |