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David Hackam
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Necrotizing enterocolitis: new insights into pathogenesis and mechanisms
DF Niño, CP Sodhi, DJ Hackam
Nature reviews Gastroenterology & hepatology 13 (10), 590-600, 2016
5502016
A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair
CL Leaphart, J Cavallo, SC Gribar, S Cetin, J Li, MF Branca, TD Dubowski, ...
The journal of immunology 179 (7), 4808-4820, 2007
5202007
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier
MD Neal, C Leaphart, R Levy, J Prince, TR Billiar, S Watkins, J Li, S Cetin, ...
The Journal of Immunology 176 (5), 3070-3079, 2006
5052006
Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation
RL Moss, RA Dimmitt, DC Barnhart, KG Sylvester, RL Brown, DM Powell, ...
New England Journal of Medicine 354 (21), 2225-2234, 2006
4962006
Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration
CP Sodhi, C Wohlford-Lenane, Y Yamaguchi, T Prindle, WB Fulton, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 314 (1 …, 2018
4062018
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes
S Gruenheid, F Canonne-Hergaux, S Gauthier, DJ Hackam, S Grinstein, ...
The Journal of experimental medicine 189 (5), 831-841, 1999
3741999
Hemorrhagic shock induces NAD (P) H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling
J Fan, Y Li, RM Levy, JJ Fan, DJ Hackam, Y Vodovotz, H Yang, KJ Tracey, ...
The journal of immunology 178 (10), 6573-6580, 2007
3592007
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice
CP Sodhi, MD Neal, R Siggers, S Sho, C Ma, MF Branca, T Prindle Jr, ...
Gastroenterology 143 (3), 708-718. e5, 2012
3292012
The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis
RJ Anand, CL Leaphart, KP Mollen, DJ Hackam
Shock 27 (2), 124-133, 2007
3042007
Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis
SC Gribar, CP Sodhi, WM Richardson, RJ Anand, GK Gittes, MF Branca, ...
The Journal of Immunology 182 (1), 636-646, 2009
2862009
Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification
DJ Hackam, OD Rotstein, W Zhang, S Gruenheid, P Gros, S Grinstein
The Journal of experimental medicine 188 (2), 351-364, 1998
2681998
Systemic inflammation and remote organ injury following trauma require HMGB1
RM Levy, KP Mollen, JM Prince, DJ Kaczorowski, R Vallabhaneni, S Liu, ...
American Journal of Physiology-Regulatory, Integrative and Comparative …, 2007
2672007
The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation
SC Gribar, RJ Anand, CP Sodhi, DJ Hackam
Journal of Leucocyte Biology 83 (3), 493-498, 2008
2522008
Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis
CE Egan, CP Sodhi, M Good, J Lin, H Jia, Y Yamaguchi, P Lu, C Ma, ...
The Journal of clinical investigation 126 (2), 495-508, 2016
2502016
Toll-like receptor-4 inhibits enterocyte proliferation via impaired β-catenin signaling in necrotizing enterocolitis
CP Sodhi, XH Shi, WM Richardson, ZS Grant, RA Shapiro, T Prindle Jr, ...
Gastroenterology 138 (1), 185-196, 2010
2462010
Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide: relevance to laparoscopic surgery
MA West, DJ Hackam, J Baker, JL Rodriguez, J Bellingham, OD Rotstein
Annals of surgery 226 (2), 179-190, 1997
2451997
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling
I Yazji, CP Sodhi, EK Lee, M Good, CE Egan, A Afrazi, MD Neal, H Jia, ...
Proceedings of the National Academy of Sciences 110 (23), 9451-9456, 2013
2442013
Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the …
M Good, CP Sodhi, CE Egan, A Afrazi, H Jia, Y Yamaguchi, P Lu, ...
Mucosal immunology 8 (5), 1166-1179, 2015
2312015
Rho is required for the initiation of calcium signaling and phagocytosis by Fcγ receptors in macrophages
DJ Hackam, OD Rotstein, A Schreiber, W Zhang, S Grinstein
The Journal of experimental medicine 186 (6), 955-966, 1997
2291997
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis
MD Neal, CP Sodhi, H Jia, M Dyer, CE Egan, I Yazji, M Good, A Afrazi, ...
Journal of Biological Chemistry 287 (44), 37296-37308, 2012
2272012
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