| Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo LLP Hanssen, MT Kassouf, AM Oudelaar, D Biggs, C Preece, DJ Downes, ... Nature cell biology 19 (8), 952-961, 2017 | 216 | 2017 |
| Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains AM Oudelaar, JOJ Davies, LLP Hanssen, JM Telenius, R Schwessinger, ... Nature genetics 50 (12), 1744-1751, 2018 | 181 | 2018 |
| A blood atlas of COVID-19 defines hallmarks of disease severity and specificity DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock, B Angus, MA Ansari, ... Cell 185 (5), 916-938. e58, 2022 | 170 | 2022 |
| DeepC: predicting 3D genome folding using megabase-scale transfer learning R Schwessinger, M Gosden, D Downes, RC Brown, AM Oudelaar, ... Nature methods 17 (11), 1118-1124, 2020 | 144 | 2020 |
| Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus DJ Downes, AR Cross, P Hua, N Roberts, R Schwessinger, AJ Cutler, ... Nature genetics 53 (11), 1606-1615, 2021 | 140 | 2021 |
| DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation L Godfrey, NT Crump, R Thorne, IJ Lau, E Repapi, D Dimou, AL Smith, ... Nature communications 10 (1), 2803, 2019 | 123 | 2019 |
| Defining genome architecture at base-pair resolution P Hua, M Badat, LLP Hanssen, LD Hentges, N Crump, DJ Downes, ... Nature 595 (7865), 125-129, 2021 | 120 | 2021 |
| Absolute quantification of transcription factors reveals principles of gene regulation in erythropoiesis MA Gillespie, CG Palii, D Sanchez-Taltavull, P Shannon, ... Molecular cell 78 (5), 960-974. e11, 2020 | 107 | 2020 |
| Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia S Mettananda, CA Fisher, D Hay, M Badat, L Quek, K Clark, P Hublitz, ... Nature communications 8 (1), 424, 2017 | 107 | 2017 |
| Hypoxia induces transcriptional and translational downregulation of the type I IFN pathway in multiple cancer cell types A Miar, E Arnaiz, E Bridges, S Beedie, AP Cribbs, DJ Downes, ... Cancer research 80 (23), 5245-5256, 2020 | 63 | 2020 |
| Characterization of the Mutagenic Spectrum of 4-Nitroquinoline 1-Oxide (4-NQO) in Aspergillus nidulans by Whole Genome Sequencing DJ Downes, M Chonofsky, K Tan, BT Pfannenstiel, SL Reck-Peterson, ... G3: Genes, Genomes, Genetics 4 (12), 2483-2492, 2014 | 58 | 2014 |
| Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo CS Simon, DJ Downes, ME Gosden, J Telenius, DR Higgs, JR Hughes, ... Development 144 (7), 1249-1260, 2017 | 43 | 2017 |
| Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA CC Hunter, KS Siebert, DJ Downes, KH Wong, SD Kreutzberger, ... Eukaryotic Cell 13 (4), 527-538, 2014 | 41 | 2014 |
| Enhancers predominantly regulate gene expression during differentiation via transcription initiation MSC Larke, R Schwessinger, T Nojima, J Telenius, RA Beagrie, ... Molecular cell 81 (5), 983-997. e7, 2021 | 40 | 2021 |
| Comparing the two leading erythroid lines BEL-A and HUDEP-2 DE Daniels, DJ Downes, I Ferrer-Vicens, DCJ Ferguson, BK Singleton, ... Haematologica 105 (8), e389, 2020 | 40 | 2020 |
| Impaired DNA demethylation of C/EBP sites causes premature aging A Schäfer, B Mekker, M Mallick, V Vastolo, E Karaulanov, D Sebastian, ... Genes & development 32 (11-12), 742-762, 2018 | 36 | 2018 |
| High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale DJ Downes, RA Beagrie, ME Gosden, J Telenius, SJ Carpenter, ... Nature Communications 12 (1), 531, 2021 | 34 | 2021 |
| Regulation of the NADP-glutamate dehydrogenase gene gdhA in Aspergillus nidulans by the Zn(II)2Cys6 transcription factor LeuB DJ Downes, MA Davis, SD Kreutzberger, BL Taig, RB Todd Microbiology 159 (Pt_12), 2467-2480, 2013 | 32 | 2013 |
| Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C AM Oudelaar, JOJ Davies, DJ Downes, DR Higgs, JR Hughes Nucleic Acids Research 45 (22), e184-e184, 2017 | 30 | 2017 |
| Reactivation of a developmentally silenced embryonic globin gene AJ King, D Songdej, DJ Downes, RA Beagrie, S Liu, M Buckley, P Hua, ... Nature communications 12 (1), 4439, 2021 | 27 | 2021 |
A. Marieke OudelaarMax Planck Institute for Biophysical Chemistry在 mpibpc.mpg.de 的电子邮件经过验证
