CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites R Jayavaradhan, DM Pillis, M Goodman, F Zhang, Y Zhang, ... Nature communications 10 (1), 2866, 2019 | 158 | 2019 |
KIT blockade is sufficient for donor hematopoietic stem cell engraftment in Fanconi anemia mice S Chandrakasan, R Jayavaradhan, J Ernst, A Shrestha, A Loberg, ... Blood, The Journal of the American Society of Hematology 129 (8), 1048-1052, 2017 | 28 | 2017 |
A versatile tool for the quantification of CRISPR/Cas9-induced genome editing events in human hematopoietic cell lines and hematopoietic stem/progenitor cells R Jayavaradhan, DM Pillis, P Malik Journal of molecular biology 431 (1), 102-110, 2019 | 22 | 2019 |
Genetic therapies for sickle cell disease R Jayavaradhan, P Malik Pediatric Clinics 65 (3), 465-480, 2018 | 12 | 2018 |
Mechanism of Human Hematopoietic Stem Cell Loss during Ex Vivo Manipulation and Gene Transfer A Shrestha, T Higashimoto, S Felker, A Loberg, R Jayavaradhan, A Hinge, ... Experimental Hematology 64, S103, 2018 | 1 | 2018 |
CRISPR/Cas9 Fusion to Dominant Negative 53BP1 Confers High Efficiency HDR-Based Genome Editing and Inhibits NHEJ Only at Cas9 Target Sites R Jayavaradhan, DM Pillis, M Goodman, F Zhang, PR Andreassen, ... MOLECULAR THERAPY 27 (4), 444-444, 2019 | | 2019 |
Optimization of Gene Editing Approaches for Human Hematopoietic Stem Cells R Jayavaradhan University of Cincinnati, 2019 | | 2019 |
A Precise Tool to Determine and Optimize Efficiency of Different DNA Double Strand Break Repair Outcomes in Hematopoietic Stem and Progenitor Cells R Jayavaradhan MOLECULAR THERAPY 26 (5), 228-229, 2018 | | 2018 |
A Precise Tool to Edit Human Hematopoietic Stem Cells at High Efficiency and Decipher and Optimize the Different Double Strand Break Repair Outcomes R Jayavaradhan, D Pillis, S McGraw, L Anastacia, PR Andreassen, ... Blood 130, 2067, 2017 | | 2017 |
KIT Blockade Is Sufficient to Sustain Donor Hematopoietic Stem Cell Engraftment in Fanconi Anemia Mice S Chandrakasan, R Jayavaradhan, E John, A Shrestha, P Dexheimer, ... Blood 126 (23), 1206, 2015 | | 2015 |