Mitochondrial STAT3 supports Ras-dependent oncogenic transformation DJ Gough, A Corlett, K Schlessinger, J Wegrzyn, AC Larner, DE Levy Science 324 (5935), 1713-1716, 2009 | 802 | 2009 |
Constitutive type I interferon modulates homeostatic balance through tonic signaling DJ Gough, NL Messina, CJP Clarke, RW Johnstone, DE Levy Immunity 36 (2), 166-174, 2012 | 489 | 2012 |
Therapeutically exploiting STAT3 activity in cancer—using tissue repair as a road map J Huynh, A Chand, D Gough, M Ernst Nature Reviews Cancer 19 (2), 82-96, 2019 | 441 | 2019 |
IFNγ signaling—Does it mean JAK–STAT? DJ Gough, DE Levy, RW Johnstone, CJ Clarke Cytokine & growth factor reviews 19 (5-6), 383-394, 2008 | 403 | 2008 |
A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction M Demaria, C Giorgi, M Lebiedzinska, G Esposito, L D'Angeli, A Bartoli, ... Aging (Albany NY) 2 (11), 823, 2010 | 303 | 2010 |
The JAK/STAT pathway in obesity and diabetes EN Gurzov, WJ Stanley, EG Pappas, HE Thomas, DJ Gough The FEBS journal 283 (16), 3002-3015, 2016 | 255 | 2016 |
Functional crosstalk between type I and II interferon through the regulated expression of STAT1 DJ Gough, NL Messina, L Hii, JA Gould, K Sabapathy, APS Robertson, ... PLoS biology 8 (4), e1000361, 2010 | 197 | 2010 |
STAT3: a multifaceted oncoprotein AC Guanizo, CD Fernando, DJ Garama, DJ Gough Growth Factors 36 (1-2), 1-14, 2018 | 169 | 2018 |
The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation DJ Gough, L Koetz, DE Levy PloS one 8 (11), e83395, 2013 | 160 | 2013 |
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression JJ Balic, H Albargy, K Luu, FJ Kirby, WSN Jayasekara, F Mansell, ... Nature communications 11 (1), 3816, 2020 | 98 | 2020 |
Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny W Lee, J Johnson, DJ Gough, J Donoghue, GLM Cagnone, V Vaghjiani, ... Cell death & disease 6 (2), e1664-e1664, 2015 | 96 | 2015 |
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages JK Dowling, R Afzal, LJ Gearing, MP Cervantes-Silva, S Annett, GM Davis, ... Nature communications 12 (1), 1460, 2021 | 95 | 2021 |
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon γ response genes DJ Gough, K Sabapathy, EYN Ko, HA Arthur, RD Schreiber, JA Trapani, ... Journal of biological chemistry 282 (2), 938-946, 2007 | 76 | 2007 |
Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma SA Greenall, YC Lim, CB Mitchell, KS Ensbey, BW Stringer, AL Wilding, ... Oncogenesis 6 (5), e336-e336, 2017 | 71 | 2017 |
A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3 DJ Garama, TJ Harris, CL White, FJ Rossello, M Abdul-Hay, DJ Gough, ... Molecular and cellular biology 35 (21), 3646-3656, 2015 | 66 | 2015 |
STAT3 supports experimental K-RasG12D–induced murine myeloproliferative neoplasms dependent on serine phosphorylation DJ Gough, IJ Marié, C Lobry, I Aifantis, DE Levy Blood, The Journal of the American Society of Hematology 124 (14), 2252-2261, 2014 | 65 | 2014 |
Mitochondrial STAT3: Powering up a potent factor DJ Garama, CL White, JJ Balic, DJ Gough Cytokine 87, 20-25, 2016 | 60 | 2016 |
Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function JE Lee, YM Yang, FX Liang, DJ Gough, DE Levy, PB Sehgal American Journal of Physiology-Cell Physiology 302 (5), C804-C820, 2012 | 58 | 2012 |
Toll‐like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2 YD Liu, L Yu, L Ying, J Balic, H Gao, NT Deng, A West, F Yan, CB Ji, ... International journal of cancer 144 (12), 3056-3069, 2019 | 46 | 2019 |
Cre-dependent DNA recombination activates a STING-dependent innate immune response G Pépin, J Ferrand, K Höning, WSN Jayasekara, JE Cain, MA Behlke, ... Nucleic acids research 44 (11), 5356-5364, 2016 | 46 | 2016 |