Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications N Altincekic, SM Korn, NS Qureshi, M Dujardin, M Ninot-Pedrosa, R Abele, ... Frontiers in molecular biosciences 8, 653148, 2021 | 45 | 2021 |
Identification of natural products inhibiting SARS-CoV-2 by targeting viral proteases: a combined in silico and in vitro approach A Wasilewicz, B Kirchweger, D Bojkova, MJ Abi Saad, J Langeder, ... Journal of Natural Products 86 (2), 264-275, 2023 | 23 | 2023 |
Ultrafast Fragment Screening Using Photo-Hyperpolarized (CIDNP) NMR F Torres, M Bütikofer, GR Stadler, A Renn, H Kadavath, R Bobrovs, ... Journal of the American Chemical Society 145 (22), 12066-12080, 2023 | 22 | 2023 |
Protein structure determination in human cells by in-cell NMR and a reporter system to optimize protein delivery or transexpression JA Gerez, NC Prymaczok, H Kadavath, D Ghosh, M Bütikofer, ... Communications Biology 5 (1), 1322, 2022 | 18 | 2022 |
Comprehensive fragment screening of the SARS‐CoV‐2 proteome explores novel chemical space for drug development H Berg, MA Wirtz Martin, N Altincekic, I Alshamleh, J Kaur Bains, ... Angewandte Chemie International Edition 61 (46), e202205858, 2022 | 18 | 2022 |
Fragment Screening and Fast Micromolar Detection on a Benchtop NMR Spectrometer Boosted by Photoinduced Hyperpolarization GR Stadler, TF Segawa, M Bütikofer, V Decker, S Loss, B Czarniecki, ... Angewandte Chemie International Edition 62 (40), e202308692, 2023 | 8 | 2023 |
High-Mass Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry for Absolute Quantitation of Noncovalent Protein–Protein Binding Interactions N Wu, L Jiao, M Bütikofer, Z Zeng, R Zenobi Analytical Chemistry 93 (31), 10982-10989, 2021 | 7 | 2021 |
Carbonyl sulfide as a prebiotic activation agent for stereo-and sequence-selective, amyloid-templated peptide elongation R Bomba, SK Rout, M Bütikofer, W Kwiatkowski, R Riek, J Greenwald Origins of Life and Evolution of Biospheres 49, 213-224, 2019 | 6 | 2019 |
Rapid Protein–Ligand Affinity Determination by Photoinduced Hyperpolarized NMR M Bütikofer, GR Stadler, H Kadavath, R Cadalbert, F Torres, R Riek Journal of the American Chemical Society, 2024 | 2 | 2024 |
Ligand-target interaction analysis by photochemically induced dynamic nuclear polarization (photo-cidnp) enhanced nmr spectroscopy F Torres, RP Riek, M Butikofer US Patent App. 18/294,558, 2024 | | 2024 |
Rescaling NMR for a Larger Deployment in Drug Discovery: Hyperpolarization and Benchtop NMR as Potential Game‐Changers M Bütikofer, GR Stadler, F Torres Chemistry‐Methods 4 (10), e202400009, 2024 | | 2024 |
Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform W Wüster, P Gebbers, A Renn, M Bütikofer, S Rüdiger, RP Riek, F Torres Magnetic Resonance 5 (1), 61-67, 2024 | | 2024 |
Targeting the Main Protease (Mpro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies N Altincekic, N Jores, F Löhr, C Richter, C Ehrhardt, MJJ Blommers, ... ACS Chemical Biology 19 (2), 563-574, 2024 | | 2024 |
From Screening to Structure: NMR-based Drug Discovery with Hyperpolarization and Isotope-free Structure Determination M Bütikofer ETH Zurich, 2024 | | 2024 |
Short Lecture “Natural products against SARS-CoV-2 or how to catch a butterfly?” A Wasilewicz, B Kirchweger, D Bojkova, MJ Abi Saad, J Langeder, ... Planta Medica 88 (15), SL-RDF-01, 2022 | | 2022 |