| Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation U Dettmer, AJ Newman, F Soldner, ES Luth, NC Kim, VE Von Saucken, ... Nature communications 6 (1), 7314, 2015 | 343 | 2015 |
| In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells U Dettmer, AJ Newman, ES Luth, T Bartels, D Selkoe Journal of Biological Chemistry 288 (9), 6371-6385, 2013 | 287 | 2013 |
| Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for Parkinson treatment S Fanning, A Haque, T Imberdis, V Baru, MI Barrasa, S Nuber, D Termine, ... Molecular cell 73 (5), 1001-1014. e8, 2019 | 241 | 2019 |
| KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity U Dettmer, AJ Newman, VE von Saucken, T Bartels, D Selkoe Proceedings of the National Academy of Sciences 112 (31), 9596-9601, 2015 | 188 | 2015 |
| Parkinson’s disease: proteinopathy or lipidopathy? S Fanning, D Selkoe, U Dettmer NPJ Parkinson's disease 6 (1), 3, 2020 | 181 | 2020 |
| Abrogating native α-synuclein tetramers in mice causes a L-DOPA-responsive motor syndrome closely resembling Parkinson’s disease S Nuber, M Rajsombath, G Minakaki, J Winkler, CP Müller, M Ericsson, ... Neuron 100 (1), 75-90. e5, 2018 | 132 | 2018 |
| New insights into cellular α-synuclein homeostasis in health and disease U Dettmer, D Selkoe, T Bartels Current opinion in neurobiology 36, 15-22, 2016 | 104 | 2016 |
| Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity ES Luth, T Bartels, U Dettmer, NC Kim, DJ Selkoe Biochemistry 54 (2), 279-292, 2015 | 96 | 2015 |
| Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells U Dettmer, N Ramalingam, VE von Saucken, TE Kim, AJ Newman, ... Human molecular genetics 26 (18), 3466-3481, 2017 | 85 | 2017 |
| Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase T Imberdis, J Negri, N Ramalingam, E Terry-Kantor, GPH Ho, S Fanning, ... Proceedings of the National Academy of Sciences 116 (41), 20760-20769, 2019 | 81 | 2019 |
| Defining the native state of α-synuclein D Selkoe, U Dettmer, E Luth, N Kim, A Newman, T Bartels Neurodegenerative Diseases 13 (2-3), 114-117, 2014 | 60 | 2014 |
| Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex U Dettmer, PH Kuhn, C Abou-Ajram, SF Lichtenthaler, M Krüger, ... Journal of Biological Chemistry 285 (34), 26174-26181, 2010 | 57 | 2010 |
| Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk R Kayed, U Dettmer, SE Lesné Journal of Parkinson's Disease 10 (3), 791-818, 2020 | 56 | 2020 |
| A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice S Nuber, AY Nam, MM Rajsombath, H Cirka, X Hronowski, J Wang, ... Annals of Neurology 89 (1), 74-90, 2021 | 50 | 2021 |
| Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity N Ramalingam, SX Jin, TE Moors, L Fonseca-Ornelas, K Shimanaka, ... npj Parkinson's Disease 9 (1), 4, 2023 | 44 | 2023 |
| A new method for quantitative immunoblotting of endogenous α-synuclein AJ Newman, D Selkoe, U Dettmer PLoS One 8 (11), e81314, 2013 | 40 | 2013 |
| The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex C Haffner, U Dettmer, T Weiler, C Haass Journal of Biological Chemistry 282 (14), 10632-10638, 2007 | 40 | 2007 |
| Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form TJ Collier, KR Srivastava, C Justman, T Grammatopoulous, B Hutter-Paier, ... Neurobiology of disease 106, 191-204, 2017 | 38 | 2017 |
| Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease U Dettmer Frontiers in Neuroscience 12, 623, 2018 | 36 | 2018 |
| Vesicle trafficking and lipid metabolism in synucleinopathy S Fanning, D Selkoe, U Dettmer Acta neuropathologica 141 (4), 491-510, 2021 | 32 | 2021 |
Dennis SelkoeCo-Director, Ann Romney Center for Neurologic Disases, Brigham and Women's Hospital在 bwh.harvard.edu 的电子邮件经过验证
