| Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or … R Sarfstein, Y Friedman, Z Attias-Geva, A Fishman, I Bruchim, H Werner PloS one 8 (4), e61537, 2013 | 163 | 2013 |
| Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras R Sarfstein, Y Gorzalczany, A Mizrahi, Y Berdichevsky, S Molshanski-Mor, ... Journal of Biological Chemistry 279 (16), 16007-16016, 2004 | 150 | 2004 |
| Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1 S Maor, D Mayer, RI Yarden, AV Lee, R Sarfstein, H Werner, MZ Papa Journal of endocrinology 191 (3), 605-612, 2006 | 146 | 2006 |
| Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells R Sarfstein, M Pasmanik-Chor, A Yeheskel, L Edry, N Shomron, ... Journal of Biological Chemistry 287 (4), 2766-2776, 2012 | 109 | 2012 |
| Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction R Sarfstein, H Werner Endocrinology 154 (5), 1672-1679, 2013 | 105 | 2013 |
| The IGF hormonal network in endometrial cancer: functions, regulation, and targeting approaches I Bruchim, R Sarfstein, H Werner Frontiers in endocrinology 5, 91120, 2014 | 102 | 2014 |
| The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice V Rubovitch, S Edut, R Sarfstein, H Werner, CG Pick Neurobiology of disease 38 (2), 299-303, 2010 | 83 | 2010 |
| Characterization of two proteins from Leishmania donovani and their use for vaccination against visceral leishmaniasis. CL Jaffe, N Rachamim, R Sarfstein Journal of immunology (Baltimore, Md.: 1950) 144 (2), 699-706, 1990 | 83 | 1990 |
| Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships A Mizrahi, Y Berdichevsky, Y Ugolev, S Molshanski-Mor, Y Nakash, ... Journal of leukocyte biology 79 (5), 881-895, 2006 | 76 | 2006 |
| Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer R Sarfstein, S Maor, N Reizner, S Abramovitch, H Werner Molecular and cellular endocrinology 252 (1-2), 241-246, 2006 | 71 | 2006 |
| Insulin-like growth factor 1 signaling axis meets p53 genome protection pathways H Werner, R Sarfstein, D LeRoith, I Bruchim Frontiers in oncology 6, 159, 2016 | 68 | 2016 |
| Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action K Nagaraj, L Lapkina-Gendler, R Sarfstein, D Gurwitz, M Pasmanik-Chor, ... Proceedings of the National Academy of Sciences 115 (5), 1045-1050, 2018 | 64 | 2018 |
| Transcriptional and epigenetic control of IGF1R gene expression: implications in metabolism and cancer H Werner, R Sarfstein Growth Hormone & IGF Research 24 (4), 112-118, 2014 | 64 | 2014 |
| The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway R Sarfstein, I Bruchim, A Fishman, H Werner PLoS One 6 (9), e24468, 2011 | 51 | 2011 |
| Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy H Werner, R Sarfstein, I Bruchim Expert opinion on investigational drugs 28 (12), 1101-1112, 2019 | 50 | 2019 |
| Long-acting insulin analogues elicit atypical signalling events mediated by the insulin receptor and insulin-like growth factor-I receptor E Yehezkel, D Weinstein, M Simon, R Sarfstein, Z Laron, H Werner Diabetologia 53, 2667-2675, 2010 | 50 | 2010 |
| p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed … Z Attias-Geva, I Bentov, D Kidron, K Amichay, R Sarfstein, A Fishman, ... European Journal of Cancer 48 (10), 1570-1580, 2012 | 46 | 2012 |
| Genome-wide profiling of laron syndrome patients identifies novel cancer protection pathways H Werner, L Lapkina-Gendler, L Achlaug, K Nagaraj, L Somri, ... Cells 8 (6), 596, 2019 | 45 | 2019 |
| The WT1 Wilms’ tumor suppressor gene product interacts with estrogen receptor-α and regulates IGF-I receptor gene transcription in breast cancer cells N Reizner, S Maor, R Sarfstein, S Abramovitch, WV Welshons, EM Curran, ... Journal of molecular endocrinology 35 (1), 135-144, 2005 | 44 | 2005 |
| Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells D Weinstein, R Sarfstein, Z Laron, H Werner Endocrine Connections 3 (1), 24-35, 2014 | 41 | 2014 |
