Cryo-EM structures of tau filaments from Alzheimer’s disease AWP Fitzpatrick, B Falcon, S He, AG Murzin, G Murshudov, HJ Garringer, ... Nature 547 (7662), 185-190, 2017 | 1835 | 2017 |
Role of intermolecular forces in defining material properties of protein nanofibrils TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, ... science 318 (5858), 1900-1903, 2007 | 865 | 2007 |
Atomic structure and hierarchical assembly of a cross-β amyloid fibril AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, ... Proceedings of the National Academy of Sciences 110 (14), 5468-5473, 2013 | 661 | 2013 |
Metastability of native proteins and the phenomenon of amyloid formation AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, ... Journal of the American Chemical Society 133 (36), 14160-14163, 2011 | 507 | 2011 |
Posttranslational modifications mediate the structural diversity of tauopathy strains T Arakhamia, CE Lee, Y Carlomagno, M Kumar, DM Duong, H Wesseling, ... Cell 180 (4), 633-644. e12, 2020 | 349 | 2020 |
Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump AWP Fitzpatrick, S Llabrés, A Neuberger, JN Blaza, XC Bai, U Okada, ... Nature Microbiology 2, 17070, 2017 | 178 | 2017 |
Cryo-EM of amyloid fibrils and cellular aggregates AWP Fitzpatrick, HR Saibil Current opinion in structural biology 58, 34-42, 2019 | 127 | 2019 |
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson PLoS computational biology 7 (10), e1002169, 2011 | 115 | 2011 |
In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells CA Waudby, C Camilloni, AWP Fitzpatrick, LD Cabrita, CM Dobson, ... PloS one 8 (8), e72286, 2013 | 107 | 2013 |
Exceptional rigidity and biomechanics of amyloid revealed by 4D electron microscopy AWP Fitzpatrick, ST Park, AH Zewail Proceedings of the National Academy of Sciences 110 (27), 10976-10981, 2013 | 99 | 2013 |
Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu CM Ho, X Li, M Lai, TC Terwilliger, JR Beck, J Wohlschlegel, DE Goldberg, ... Nature methods 17 (1), 79-85, 2020 | 97 | 2020 |
Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy GT Debelouchina, MJ Bayro, AW Fitzpatrick, V Ladizhansky, MT Colvin, ... Journal of the American Chemical Society 135 (51), 19237-19247, 2013 | 96 | 2013 |
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases A Chang, X Xiang, J Wang, C Lee, T Arakhamia, M Simjanoska, C Wang, ... Cell 185 (8), 1346-1355. e15, 2022 | 91 | 2022 |
Four-dimensional electron microscopy: Ultrafast imaging, diffraction and spectroscopy in materials science and biology GM Vanacore, AWP Fitzpatrick, AH Zewail Nano Today 11 (2), 228-249, 2016 | 91 | 2016 |
Nanomechanics and intermolecular forces of amyloid revealed by four-dimensional electron microscopy AWP Fitzpatrick, GM Vanacore, AH Zewail Proceedings of the National Academy of Sciences 112 (11), 3380-3385, 2015 | 57 | 2015 |
Twisting transition between crystalline and fibrillar phases of aggregated peptides TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, ... Physical Review Letters 109 (15), 158101, 2012 | 55 | 2012 |
The AD tau core spontaneously self-assembles and recruits full-length tau to filaments Y Carlomagno, S Manne, M DeTure, M Prudencio, YJ Zhang, ... Cell reports 34 (11), 2021 | 48 | 2021 |
4D cryo-electron microscopy of proteins AWP Fitzpatrick, UJ Lorenz, GM Vanacore, AH Zewail Journal of the American Chemical Society 135 (51), 19123-19126, 2013 | 45 | 2013 |
Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR MA Caporini, VS Bajaj, M Veshtort, A Fitzpatrick, CE MacPhee, ... The Journal of Physical Chemistry B 114 (42), 13555-13561, 2010 | 34 | 2010 |
Posttranslational modifications mediate the structural diversity of tauopathy strains T Arakhamia, CE Lee, Y Carlomagno, M Kumar, DM Duong, H Wesseling, ... Cell 184 (25), 6207-6210, 2021 | 27 | 2021 |