How adverse outcome pathways can aid the development and use of computational prediction models for regulatory toxicology C Wittwehr, H Aladjov, G Ankley, HJ Byrne, J de Knecht, E Heinzle, ... Toxicological Sciences 155 (2), 326-336, 2017 | 168 | 2017 |
t4 workshop report: pathways of toxicity A Kleensang, A Maertens, M Rosenberg, S Fitzpatrick, J Lamb, ... Altex 31 (1), 53, 2014 | 109 | 2014 |
Alternative methods for regulatory toxicology–a state-of-the-art review A Worth, J Barroso, S Bremer, J Burton, S Casati, S Coecke, R Corvi, ... JRC Sci Policy Rep EUR 26797, 1-475, 2014 | 68 | 2014 |
Creating a structured adverse outcome pathway knowledgebase via ontology-based annotations C Ives, I Campia, RL Wang, C Wittwehr, S Edwards Applied in vitro toxicology 3 (4), 298-311, 2017 | 61 | 2017 |
EURL ECVAM status report on the development, validation and regulatory acceptance of alternative methods and approaches (2019) D Asturiol Bofill Publications Office of the European Union, 2020 | 52 | 2020 |
Application of AOPs to assist regulatory assessment of chemical risks–Case studies, needs and recommendations L Bajard, O Adamovsky, K Audouze, K Baken, R Barouki, JB Beltman, ... Environmental Research 217, 114650, 2023 | 41 | 2023 |
Artificial Intelligence for chemical risk assessment C Wittwehr, P Blomstedt, JP Gosling, T Peltola, B Raffael, AN Richarz, ... Computational Toxicology 13, 100114, 2020 | 39 | 2020 |
diXa: a data infrastructure for chemical safety assessment DM Hendrickx, HJWL Aerts, F Caiment, D Clark, TMD Ebbels, CT Evelo, ... Bioinformatics 31 (9), 1505-1507, 2015 | 38 | 2015 |
Systematic organization of COVID-19 data supported by the adverse outcome pathway framework P Nymark, M Sachana, SB Leite, J Sund, CE Krebs, K Sullivan, ... Frontiers in public health 9, 638605, 2021 | 31 | 2021 |
Towards a qAOP framework for predictive toxicology-Linking data to decisions A Paini, I Campia, MTD Cronin, D Asturiol, L Ceriani, TE Exner, W Gao, ... Computational Toxicology 21, 100195, 2022 | 21 | 2022 |
Non-animal methods in science and regulation V ZUANG, A DURA, LE AHS, J BARROSO, LS BATISTA, E BERGGREN, ... | 21 | 2022 |
Understanding COVID-19 through adverse outcome pathways–2nd CIAO AOP Design Workshop C Wittwehr, MJ Amorim, LA Clerbaux, C Krebs, B Landesmann, ... ALTEX-Alternatives to animal experimentation 38 (2), 351-357, 2021 | 19 | 2021 |
Alzheimer’s disease, and breast and prostate cancer research: Translational failures and the importance to monitor outputs and impact of funded research F Pistollato, C Bernasconi, J McCarthy, I Campia, C Desaintes, C Wittwehr, ... Animals 10 (7), 1194, 2020 | 18 | 2020 |
The adverse outcome pathway: a conceptual framework to support toxicity testing in the twenty-first century E Perkins, N Garcia-Reyero, S Edwards, C Wittwehr, D Villeneuve, ... Computational systems toxicology, 1-26, 2015 | 17 | 2015 |
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease–3rd CIAO AOP Design Workshop LA Clerbaux, N Amigó, MJ Amorim, A Bal-Price, SB Leite, A Beronius, ... Altex 39 (2), 322–335, 2022 | 16 | 2022 |
Addressing evidence needs in chemicals policy and regulation A CARUSI, C WITTWEHR, M WHELAN | 12 | 2022 |
Bridging across methods in the biosciences A CARUSI, M WHELAN, C WITTWEHR | 11 | 2019 |
Accelerating progress in the replacement, reduction and refinement of animal testing through better knowledge sharing T Holley, G Bowe, I Campia, S Belz, E Berggren, A Janusch-Roi, ... Publications Office of the European Union, 2016 | 11 | 2016 |
The adverse outcome pathway framework applied to neurological symptoms of COVID-19 HT Hogberg, A Lam, E Ohayon, MA Shahbaz, LA Clerbaux, A Bal-Price, ... Cells 11 (21), 3411, 2022 | 10 | 2022 |
OECD harmonised template 201: Structuring and reporting mechanistic information to foster the integration of new approach methodologies for hazard and risk assessment of chemicals E Carnesecchi, I Langezaal, P Browne, S Batista-Leite, I Campia, ... Regulatory Toxicology and Pharmacology, 105426, 2023 | 8 | 2023 |