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TAWANDA ZININGA
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引用次数
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Heat shock proteins as immunomodulants
T Zininga, L Ramatsui, A Shonhai
Molecules 23 (11), 2846, 2018
3262018
Plasmodium falciparum Hop (PfHop) interacts with the Hsp70 chaperone in a nucleotide-dependent fashion and exhibits ligand selectivity
T Zininga, S Makumire, GW Gitau, JM Njunge, OJ Pooe, H Klimek, ...
PLoS One 10 (8), e0135326, 2015
532015
Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion
T Zininga, I Achilonu, H Hoppe, E Prinsloo, HW Dirr, A Shonhai
Cell Stress and Chaperones 21 (3), 499-513, 2016
492016
Overexpression, purification and characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) protein
T Zininga, I Achilonu, H Hoppe, E Prinsloo, HW Dirr, A Shonhai
PLoS One 10 (6), e0129445, 2015
422015
Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors
F Kayamba, T Malimabe, IK Ademola, OJ Pooe, ND Kushwaha, ...
European Journal of Medicinal Chemistry 217, 113330, 2021
412021
Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70
T Zininga, OJ Pooe, PB Makhado, L Ramatsui, E Prinsloo, I Achilonu, ...
Cell Stress and Chaperones 22 (5), 707-715, 2017
412017
Structural and biochemical characterization of Plasmodium falciparum Hsp70‐x reveals functional versatility of its C‐terminal EEVN motif
B Mabate, T Zininga, L Ramatsui, S Makumire, I Achilonu, HW Dirr, ...
Proteins: Structure, Function, and Bioinformatics 86 (11), 1189-1201, 2018
402018
Small molecule inhibitors targeting the heat shock protein system of human obligate protozoan parasites
T Zininga, A Shonhai
International journal of molecular sciences 20 (23), 5930, 2019
392019
(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional …
T Zininga, L Ramatsui, PB Makhado, S Makumire, I Achilinou, H Hoppe, ...
Molecules 22 (12), 2139, 2017
362017
Comparative structure-function features of Hsp70s of Plasmodium falciparum and human origins
G Chakafana, T Zininga, A Shonhai
Biophysical reviews 11 (4), 591-602, 2019
332019
Comparative in vitro cytotoxic, anti-inflammatory and anti-microbiological activities of two indigenous Venda medicinal plants
MT Sigidi, CP Anokwuru, T Zininga, MP Tshisikhawe, A Shonhai, ...
Translational Medicine Communications 1, 1-7, 2016
282016
The link that binds: the linker of Hsp70 as a helm of the protein’s function
G Chakafana, T Zininga, A Shonhai
Biomolecules 9 (10), 543, 2019
272019
Are Heat Shock Proteins Druggable Candidates?
AS Tawanda Zininga
American Journal of Biochemistry and Biotechnology 10 (4), 208-210, 2014
252014
Comparative Characterization of Plasmodium falciparum Hsp70-1 Relative to E. coli DnaK Reveals the Functional Specificity of the Parasite Chaperone
CM Lebepe, PR Matambanadzo, XH Makhoba, I Achilonu, T Zininga, ...
Biomolecules 10 (6), 856, 2020
242020
Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function
T Zininga, CP Anokwuru, MT Sigidi, MP Tshisikhawe, IID Ramaite, ...
Molecules 22 (8), 1224, 2017
212017
Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum s-adenosylmethionine decarboxylase protein produced in Escherichia coli
XH Makhoba, A Burger, D Coertzen, T Zininga, LM Birkholtz, A Shonhai
PLoS One 11 (3), e0152626, 2016
202016
Mutation of GGMP Repeat Segments of Plasmodium falciparum Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding
S Makumire, TH Dongola, G Chakafana, L Tshikonwane, CT Chauke, ...
International Journal of Molecular Sciences 22 (4), 2226, 2021
162021
Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future
ML Stofberg, C Caillet, M de Villiers, T Zininga
Cells 10 (11), 2849, 2021
152021
Phenolic contents, antioxidant activity and spectroscopic characteristics of Pterocarpus angolensis DC. stem bark fractions.
CP Anokwuru, MT Sigidi, T Zininga, MP Tshisikhawe, A Shonhai, ...
152017
Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected …
S Makumire, T Zininga, J Vahokoski, I Kursula, A Shonhai
PLoS One 15 (4), e0226657, 2020
142020
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