| The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets M Legraverend, DS Grierson Bioorganic & medicinal chemistry 14 (12), 3987-4006, 2006 | 420 | 2006 |
| Recent advances in the synthesis of purine derivatives and their precursors M Legraverend Tetrahedron 64 (37), 8585-8603, 2008 | 148 | 2008 |
| Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2− inhibitor complex M Legraverend, P Tunnah, M Noble, P Ducrot, O Ludwig, DS Grierson, ... Journal of medicinal chemistry 43 (7), 1282-1292, 2000 | 104 | 2000 |
| Synthesis and in vitro evaluation of novel 2, 6, 9-trisubstituted purines acting as cyclin-dependent kinase inhibitors M Legraverend, O Ludwig, E Bisagni, S Leclerc, L Meijer, N Giocanti, ... Bioorganic & medicinal chemistry 7 (7), 1281-1293, 1999 | 92 | 1999 |
| Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases M Legraverend, O Ludwig, E Bisagni, S Leclerc, L Meijer Bioorganic & medicinal chemistry letters 8 (7), 793-798, 1998 | 68 | 1998 |
| Synthesis and evaluation of “AZT-HEPT”,“AZT-pyridinone”, and “ddC-HEPT” conjugates as inhibitors of HIV reverse transcriptase R Pontikis, V Dollé, J Guillaumel, E Dechaux, R Note, CH Nguyen, ... Journal of medicinal chemistry 43 (10), 1927-1939, 2000 | 63 | 2000 |
| Traceless solid-phase synthesis of 2, 6, 9-trisubstituted purines from resin bound 6-thiopurines V Brun, M Legraverend, DS Grierson Tetrahedron 58 (39), 7911-7923, 2002 | 62 | 2002 |
| Microwave-assisted Pd/Cu-catalyzed C-8 direct alkenylation of purines and related azoles: An alternative access to 6, 8, 9-trisubstituted purines R Vabre, F Chevot, M Legraverend, S Piguel The Journal of Organic Chemistry 76 (22), 9542-9547, 2011 | 53 | 2011 |
| 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors P Ducrot, M Legraverend, DS Grierson Journal of medicinal chemistry 43 (22), 4098-4108, 2000 | 53 | 2000 |
| The effect of 5-fluorouridine 5'-triphosphate on RNA transcribed in isolated nuclei in vitro RI GLAZER, M LEGRAVEREND Molecular Pharmacology 17 (2), 279-282, 1980 | 52 | 1980 |
| Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluation RM Suarez, F Chevot, A Cavagnino, N Saettel, F Radvanyi, S Piguel, ... European journal of medicinal chemistry 61, 2-25, 2013 | 43 | 2013 |
| Cyclin-dependent kinase (CDK) inhibitors: development of a general strategy for the construction of 2, 6, 9-trisubstituted purine libraries. Part 1 V Brun, M Legraverend, DS Grierson Tetrahedron Letters 42 (46), 8161-8164, 2001 | 42 | 2001 |
| Purine derivatives having, in particular, antiproliferative properties, and their biological uses L Meijer, E Bisagni, M Legraverend US Patent 6,316,456, 2001 | 41 | 2001 |
| Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors V Dollé, CH Nguyen, M Legraverend, AM Aubertin, A Kirn, ML Andreola, ... Journal of medicinal chemistry 43 (21), 3949-3962, 2000 | 41 | 2000 |
| (.+-.)-2-Amino-3, 4-dihydro-7-[2, 3-dihydroxy-4-(hydroxymethyl)-1-cyclopentyl]-7H-pyrrolo [2, 3-d] pyrimidin-4-ones: new carbocyclic analogs of 7-deazaguanosine with antiviral … M Legraverend, RMN Ngongo-Tekam, E Bisagni, A Zerial Journal of medicinal chemistry 28 (10), 1477-1480, 1985 | 36 | 1985 |
| Cyclin-dependent kinase (CDK) inhibitors: development of a general strategy for the construction of 2, 6, 9-trisubstituted purine libraries. Part 3 V Brun, M Legraverend, DS Grierson Tetrahedron Letters 42 (46), 8169-8171, 2001 | 35 | 2001 |
| Synthesis of 6, 7, 8-trisubstituted purines via a copper-catalyzed amidation reaction N Ibrahim, M Legraverend The Journal of Organic Chemistry 74 (1), 463-465, 2009 | 34 | 2009 |
| Selective amidation of 2, 6-dihalogenopurines: application to the synthesis of new 2, 6, 9-trisubstituted purines S Piguel, M Legraverend The Journal of Organic Chemistry 72 (18), 7026-7029, 2007 | 33 | 2007 |
| Synthesis of new carbocyclic oxetanocin analogues T Gharbaoui, M Legraverend, O Ludwig, E Bisagni, AM Aubertin, ... Tetrahedron 51 (6), 1641-1652, 1995 | 32 | 1995 |
| Regioselective Sonogashira cross-coupling reactions of 6-chloro-2, 8-diiodo-9-THP-9H-purine with alkyne derivatives N Ibrahim, F Chevot, M Legraverend Tetrahedron Letters 52 (2), 305-307, 2011 | 30 | 2011 |
Laurent Meijer在 manros-therapeutics.com 的电子邮件经过验证
