| Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity O Dufva, J Koski, P Maliniemi, A Ianevski, J Klievink, J Leitner, P Pölönen, ... Blood, The Journal of the American Society of Hematology 135 (9), 597-609, 2020 | 173 | 2020 |
| Immunogenomic landscape of hematological malignancies O Dufva, P Pölönen, O Brück, MAI Keränen, J Klievink, J Mehtonen, ... Cancer Cell 38 (3), 380-399. e13, 2020 | 147 | 2020 |
| Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia H Kuusanmäki, AM Leppä, P Pölönen, M Kontro, O Dufva, D Deb, ... Haematologica 105 (3), 708, 2020 | 135 | 2020 |
| Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target O Dufva, M Kankainen, T Kelkka, N Sekiguchi, SA Awad, S Eldfors, ... Nature communications 9 (1), 1567, 2018 | 130 | 2018 |
| Implementing a functional precision medicine tumor board for acute myeloid leukemia D Malani, A Kumar, O Brück, M Kontro, B Yadav, M Hellesøy, ... Cancer discovery 12 (2), 388-401, 2022 | 91 | 2022 |
| Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML O Brück, S Blom, O Dufva, R Turkki, H Chheda, A Ribeiro, P Kovanen, ... Leukemia 32 (7), 1643-1656, 2018 | 91 | 2018 |
| Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling EI Andersson, S Pützer, B Yadav, O Dufva, S Khan, L He, L Sellner, ... Leukemia 32 (3), 774-787, 2018 | 87 | 2018 |
| Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance Z Wiener, J Högström, V Hyvönen, AM Band, P Kallio, T Holopainen, ... Cell reports 8 (6), 1943-1956, 2014 | 81 | 2014 |
| Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia K Kämpjärvi, TM Järvinen, T Heikkinen, AS Ruppert, L Senter, KW Hoag, ... Oncotarget 6 (3), 1884, 2015 | 62 | 2015 |
| Genome-scale screens identify factors regulating tumor cell responses to natural killer cells M Sheffer, E Lowry, N Beelen, M Borah, SNA Amara, CC Mader, JA Roth, ... Nature Genetics 53 (8), 1196-1206, 2021 | 61 | 2021 |
| Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival O Brück, O Dufva, H Hohtari, S Blom, R Turkki, M Ilander, P Kovanen, ... Blood advances 4 (2), 274-286, 2020 | 49 | 2020 |
| Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia H Kuusanmäki, O Dufva, M Vähä-Koskela, AM Leppä, J Huuhtanen, ... Blood 141 (13), 1610-1625, 2023 | 40 | 2023 |
| RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses S Adnan Awad, O Dufva, A Ianevski, B Ghimire, J Koski, P Maliniemi, ... Leukemia 35 (4), 1087-1099, 2021 | 35 | 2021 |
| Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma J Huuhtanen, H Kasanen, K Peltola, T Lönnberg, V Glumoff, O Brück, ... The Journal of Clinical Investigation 133 (6), 2023 | 31 | 2023 |
| Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling H Kuusanmäki, O Dufva, E Parri, AJ van Adrichem, H Rajala, ... Oncotarget 8 (57), 97516, 2017 | 30 | 2017 |
| Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis MAS Toledo, M Gatz, S Sontag, KV Gleixner, G Eisenwort, K Feldberg, ... Blood, The Journal of the American Society of Hematology 137 (15), 2070-2084, 2021 | 29 | 2021 |
| Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia H Kuusanmäki, S Kytölä, I Vänttinen, T Ruokoranta, A Ranta, ... Haematologica 108 (7), 1768, 2023 | 22 | 2023 |
| Data-driven characterization of molecular phenotypes across heterogeneous sample collections J Mehtonen, P Pölönen, S Häyrynen, O Dufva, J Lin, T Liuksiala, ... Nucleic acids research 47 (13), e76-e76, 2019 | 20 | 2019 |
| Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers O Dufva, S Gandolfi, J Huuhtanen, O Dashevsky, H Duàn, K Saeed, ... Immunity 56 (12), 2816-2835. e13, 2023 | 10 | 2023 |
| Targeting apoptosis pathways with BCL2 and MDM2 inhibitors in adult B-cell acute lymphoblastic leukemia H Hohtari, M Kankainen, S Adnan-Awad, B Yadav, S Potdar, A Ianevski, ... HemaSphere 6 (3), e701, 2022 | 10 | 2022 |
