Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders DJ Baker, T Wijshake, T Tchkonia, NK LeBrasseur, BG Childs, ... Nature 479 (7372), 232-236, 2011 | 3709 | 2011 |
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs YI Zhu, T Tchkonia, T Pirtskhalava, AC Gower, H Ding, N Giorgadze, ... Aging cell 14 (4), 644-658, 2015 | 2076 | 2015 |
Senolytics improve physical function and increase lifespan in old age M Xu, T Pirtskhalava, JN Farr, BM Weigand, AK Palmer, MM Weivoda, ... Nature medicine 24 (8), 1246-1256, 2018 | 1767 | 2018 |
Adverse events associated with testosterone administration S Basaria, AD Coviello, TG Travison, TW Storer, WR Farwell, AM Jette, ... New England Journal of Medicine 363 (2), 109-122, 2010 | 1729 | 2010 |
Cellular senescence mediates fibrotic pulmonary disease MJ Schafer, TA White, K Iijima, AJ Haak, G Ligresti, EJ Atkinson, AL Oberg, ... Nature communications 8 (1), 14532, 2017 | 1274 | 2017 |
Targeting cellular senescence prevents age-related bone loss in mice JN Farr, M Xu, MM Weivoda, DG Monroe, DG Fraser, JL Onken, ... Nature medicine 23 (9), 1072-1079, 2017 | 950 | 2017 |
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease LTJ Hickson, LGPL Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ... EBioMedicine 47, 446-456, 2019 | 915* | 2019 |
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, ... EBioMedicine 40, 554-563, 2019 | 911 | 2019 |
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals C Handschin, S Chin, P Li, F Liu, E Maratos-Flier, NK LeBrasseur, Z Yan, ... Journal of Biological Chemistry 282 (41), 30014-30021, 2007 | 754 | 2007 |
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age M Xu, T Tchkonia, H Ding, M Ogrodnik, ER Lubbers, T Pirtskhalava, ... Proceedings of the National Academy of Sciences 112 (46), E6301-E6310, 2015 | 692 | 2015 |
High‐velocity resistance training increases skeletal muscle peak power in older women RA Fielding, NK LeBrasseur, A Cuoco, J Bean, K Mizer, MAF Singh Journal of the American Geriatrics Society 50 (4), 655-662, 2002 | 625 | 2002 |
Targeting senescent cells enhances adipogenesis and metabolic function in old age M Xu, AK Palmer, H Ding, MM Weivoda, T Pirtskhalava, TA White, A Sepe, ... elife 4, e12997, 2015 | 542 | 2015 |
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice Y Izumiya, T Hopkins, C Morris, K Sato, L Zeng, J Viereck, JA Hamilton, ... Cell metabolism 7 (2), 159-172, 2008 | 503 | 2008 |
The transcriptional coactivator PGC-1β drives the formation of oxidative type IIX fibers in skeletal muscle Z Arany, N Lebrasseur, C Morris, E Smith, W Yang, Y Ma, S Chin, ... Cell metabolism 5 (1), 35-46, 2007 | 481 | 2007 |
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction AK Palmer, M Xu, YI Zhu, T Pirtskhalava, MM Weivoda, CM Hachfeld, ... Aging cell 18 (3), e12950, 2019 | 479 | 2019 |
High-intensity resistance training improves muscle strength, self-reported function, and disability in long-term stroke survivors MM Ouellette, NK LeBrasseur, JF Bean, E Phillips, J Stein, WR Frontera, ... Stroke 35 (6), 1404-1409, 2004 | 467 | 2004 |
Identification of senescent cells in the bone microenvironment JN Farr, DG Fraser, H Wang, K Jaehn, MB Ogrodnik, MM Weivoda, ... Journal of Bone and Mineral Research 31 (11), 1920-1929, 2016 | 446 | 2016 |
Cellular senescence in type 2 diabetes: a therapeutic opportunity AK Palmer, T Tchkonia, NK LeBrasseur, EN Chini, M Xu, JL Kirkland Diabetes 64 (7), 2289-2298, 2015 | 419 | 2015 |
Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance L Liu, D Brown, M McKee, NK LeBrasseur, D Yang, KH Albrecht, K Ravid, ... Cell metabolism 8 (4), 310-317, 2008 | 413 | 2008 |
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence R Anderson, A Lagnado, D Maggiorani, A Walaszczyk, E Dookun, ... The EMBO journal 38 (5), e100492, 2019 | 393 | 2019 |