The palladium-catalyzed trifluoromethylation of aryl chlorides EJ Cho, TD Senecal, T Kinzel, Y Zhang, DA Watson, SL Buchwald Science 328 (5986), 1679-1681, 2010 | 777 | 2010 |
A new palladium precatalyst allows for the fast Suzuki− Miyaura coupling reactions of unstable polyfluorophenyl and 2-heteroaryl boronic acids T Kinzel, Y Zhang, SL Buchwald Journal of the American Chemical Society 132 (40), 14073-14075, 2010 | 710 | 2010 |
Formation of ArF from LPdAr (F): catalytic conversion of aryl triflates to aryl fluorides DA Watson, M Su, G Teverovskiy, Y Zhang, J García-Fortanet, T Kinzel, ... Science 325 (5948), 1661-1664, 2009 | 707 | 2009 |
Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials S Bloom, C Liu, DK Kölmel, JX Qiao, Y Zhang, MA Poss, WR Ewing, ... Nature chemistry 10 (2), 205-211, 2018 | 328 | 2018 |
Molybdenum-catalyzed asymmetric allylation of 3-alkyloxindoles: Application to the formal total synthesis of (−)-physostigmine BM Trost, Y Zhang Journal of the American Chemical Society 128 (14), 4590-4591, 2006 | 242 | 2006 |
Mo-catalyzed regio-, diastereo-, and enantioselective allylic alkylation of 3-aryloxindoles BM Trost, Y Zhang Journal of the American Chemical Society 129 (47), 14548-14549, 2007 | 211 | 2007 |
Evidence for in situ catalyst modification during the Pd-catalyzed conversion of aryl triflates to aryl fluorides TJ Maimone, PJ Milner, T Kinzel, Y Zhang, MK Takase, SL Buchwald Journal of the American Chemical Society 133 (45), 18106-18109, 2011 | 173 | 2011 |
An improved palladium-catalyzed conversion of aryl and vinyl triflates to bromides and chlorides J Pan, X Wang, Y Zhang, SL Buchwald Organic letters 13 (18), 4974-4976, 2011 | 109 | 2011 |
Molybdenum‐Catalyzed Asymmetric Allylic Alkylation of 3‐Alkyloxindoles: Reaction Development and Applications BM Trost, Y Zhang Chemistry–A European Journal 17 (10), 2916-2922, 2011 | 104 | 2011 |
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity BA Seigal, WH Connors, A Fraley, RM Borzilleri, PH Carter, SL Emanuel, ... Journal of Medicinal Chemistry 58 (6), 2855-2861, 2015 | 95 | 2015 |
Catalytic double stereoinduction in asymmetric allylic alkylation of oxindoles BM Trost, Y Zhang Chemistry–A European Journal 16 (1), 296-303, 2010 | 89 | 2010 |
Studying regioisomer formation in the Pd-catalyzed fluorination of aryl triflates by deuterium labeling PJ Milner, T Kinzel, Y Zhang, SL Buchwald Journal of the American Chemical Society 136 (44), 15757-15766, 2014 | 58 | 2014 |
A catalytic asymmetric total synthesis of (−)-perophoramidine BM Trost, M Osipov, S Krüger, Y Zhang Chemical science 6 (1), 349-353, 2015 | 52 | 2015 |
Acoustic ejection/full-scan mass spectrometry analysis for high-throughput compound quality control J Zhang, Y Zhang, C Liu, T Covey, J Nielsen, S Li, H Weller, W Shou SLAS TECHNOLOGY: Translating Life Sciences Innovation 26 (2), 178-188, 2021 | 31 | 2021 |
Direct N-Carbamoylation of 3-Monosubstituted Oxindoles with Alkyl Imidazole Carboxylates BM Trost, Y Zhang, T Zhang The Journal of Organic Chemistry 74 (14), 5115-5117, 2009 | 24 | 2009 |
Dimeric macrocyclic antagonists of inhibitor of apoptosis proteins for the treatment of cancer Y Zhang, BA Seigal, NK Terrett, RL Talbott, J Fargnoli, JG Naglich, ... ACS Medicinal Chemistry Letters 6 (7), 770-775, 2015 | 23 | 2015 |
Discovery of 4-azaindole inhibitors of TGFβRI as immuno-oncology agents Y Zhang, Y Zhao, AJ Tebben, S Sheriff, M Ruzanov, MP Fereshteh, Y Fan, ... ACS Medicinal Chemistry Letters 9 (11), 1117-1122, 2018 | 21 | 2018 |
Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates NS Chowdari, Y Zhang, I McDonald, W Johnson, DR Langley, ... Journal of Medicinal Chemistry 63 (22), 13913-13950, 2020 | 14 | 2020 |
Microscale purification in support of high-throughput medicinal chemistry CL Barhate, AF Donnell, M Davies, L Li, Y Zhang, F Yang, R Black, G Zipp, ... Chemical Communications 57 (84), 11037-11040, 2021 | 12 | 2021 |
Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads AF Donnell, Y Zhang, EM Stang, DD Wei, AJ Tebben, HL Perez, ... Bioorganic & Medicinal Chemistry Letters 27 (23), 5267-5271, 2017 | 10 | 2017 |