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Aochiu Chen
Aochiu Chen
Senior Scientist, Amgen Inc.
在 amgen.com 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Type II fatty acid and polyketide synthases: deciphering protein–protein and protein–substrate interactions
A Chen, RN Re, MD Burkart
Natural product reports 35 (10), 1029-1045, 2018
862018
Gating mechanism of elongating β-ketoacyl-ACP synthases
JT Mindrebo, A Patel, WE Kim, TD Davis, A Chen, TG Bartholow, ...
Nature communications 11 (1), 1727, 2020
502020
Structural basis for selectivity in a highly reducing type II polyketide synthase
D Du, Y Katsuyama, M Horiuchi, S Fushinobu, A Chen, TD Davis, ...
Nature chemical biology 16 (7), 776-782, 2020
392020
Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases
JT Mindrebo, A Chen, WE Kim, RN Re, TD Davis, JP Noel, MD Burkart
ACS catalysis 11 (12), 6787-6799, 2021
172021
Enzymology of standalone elongating ketosynthases
A Chen, Z Jiang, M Burkart
Chemical Science 13, 4225-4238, 2022
62022
Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states
A Chen, JT Mindrebo, TD Davis, WE Kim, Y Katsuyama, Z Jiang, ...
Acta Crystallographica Section D 78 (9), 1171-1179, 2022
32022
Masked cerulenin enables a dual-site selective protein crosslink
Z Jiang, A Chen, J Chen, A Sekhon, GV Louie, JP Noel, JJ La Clair, ...
Chemical Science 14 (39), 10925-10933, 2023
22023
Cryptic Cerulenin Rearrangement in Ketosynthase Covalent Inhibition
Z Jiang, JA Chen, OG Mohamed, J Huynh, A Chen, A Tripathi, JJ La Clair, ...
Journal of the American Chemical Society, 2024
2024
Visualizing the interface of biotin and fatty acid biosynthesis through SuFEx probes
A Chen, RN Re, TD Davis, K Tran, YW Moriuchi, S Wu, JJ La Clair, ...
Journal of the American Chemical Society 146 (2), 1388-1395, 2024
2024
Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein
Y Suo, A Chen, JJ La Clair, MD Burkart
Biochemistry 62 (24), 3548-3553, 2023
2023
A Computational Perspective on the Gating Mechanism of β-Ketoacyl-ACP Synthases
A Patel, JT MIndrebo, WE Kim, A Chen, TG Bartholow, TD Davis, ...
Biophysical Journal 118 (3), 502a, 2020
2020
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