Type II fatty acid and polyketide synthases: deciphering protein–protein and protein–substrate interactions A Chen, RN Re, MD Burkart Natural product reports 35 (10), 1029-1045, 2018 | 86 | 2018 |
Gating mechanism of elongating β-ketoacyl-ACP synthases JT Mindrebo, A Patel, WE Kim, TD Davis, A Chen, TG Bartholow, ... Nature communications 11 (1), 1727, 2020 | 50 | 2020 |
Structural basis for selectivity in a highly reducing type II polyketide synthase D Du, Y Katsuyama, M Horiuchi, S Fushinobu, A Chen, TD Davis, ... Nature chemical biology 16 (7), 776-782, 2020 | 39 | 2020 |
Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases JT Mindrebo, A Chen, WE Kim, RN Re, TD Davis, JP Noel, MD Burkart ACS catalysis 11 (12), 6787-6799, 2021 | 17 | 2021 |
Enzymology of standalone elongating ketosynthases A Chen, Z Jiang, M Burkart Chemical Science 13, 4225-4238, 2022 | 6 | 2022 |
Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states A Chen, JT Mindrebo, TD Davis, WE Kim, Y Katsuyama, Z Jiang, ... Acta Crystallographica Section D 78 (9), 1171-1179, 2022 | 3 | 2022 |
Masked cerulenin enables a dual-site selective protein crosslink Z Jiang, A Chen, J Chen, A Sekhon, GV Louie, JP Noel, JJ La Clair, ... Chemical Science 14 (39), 10925-10933, 2023 | 2 | 2023 |
Cryptic Cerulenin Rearrangement in Ketosynthase Covalent Inhibition Z Jiang, JA Chen, OG Mohamed, J Huynh, A Chen, A Tripathi, JJ La Clair, ... Journal of the American Chemical Society, 2024 | | 2024 |
Visualizing the interface of biotin and fatty acid biosynthesis through SuFEx probes A Chen, RN Re, TD Davis, K Tran, YW Moriuchi, S Wu, JJ La Clair, ... Journal of the American Chemical Society 146 (2), 1388-1395, 2024 | | 2024 |
Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein Y Suo, A Chen, JJ La Clair, MD Burkart Biochemistry 62 (24), 3548-3553, 2023 | | 2023 |
A Computational Perspective on the Gating Mechanism of β-Ketoacyl-ACP Synthases A Patel, JT MIndrebo, WE Kim, A Chen, TG Bartholow, TD Davis, ... Biophysical Journal 118 (3), 502a, 2020 | | 2020 |