| Structural basis of membrane binding by Gla domains of vitamin K–dependent proteins M Huang, AC Rigby, X Morelli, MA Grant, G Huang, B Furie, B Seaton, ... Nature Structural & Molecular Biology 10 (9), 751-756, 2003 | 300 | 2003 |
| Chemical and structural lessons from recent successes in protein–protein interaction inhibition (2P2I) X Morelli, R Bourgeas, P Roche Current opinion in chemical biology 15 (4), 475-481, 2011 | 247 | 2011 |
| Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes M Bouvet, A Lugari, CC Posthuma, JC Zevenhoven, S Bernard, S Betzi, ... Journal of Biological Chemistry 289 (37), 25783-25796, 2014 | 236 | 2014 |
| 2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions MJ Basse, S Betzi, R Bourgeas, S Bouzidi, B Chetrit, V Hamon, X Morelli, ... Nucleic acids research 41 (D1), D824-D827, 2012 | 180 | 2012 |
| Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database R Bourgeas, MJ Basse, X Morelli, P Roche PloS one 5 (3), e9598, 2010 | 144 | 2010 |
| Protein–protein interaction inhibition (2P2I) combining high throughput and virtual screening: application to the HIV-1 Nef protein S Betzi, A Restouin, S Opi, ST Arold, I Parrot, F Guerlesquin, X Morelli, ... Proceedings of the National Academy of Sciences 104 (49), 19256-19261, 2007 | 144 | 2007 |
| Exploring selective inhibition of the first bromodomain of the human bromodomain and extra-terminal domain (BET) proteins B Raux, Y Voitovich, C Derviaux, A Lugari, E Rebuffet, S Milhas, S Priet, ... Journal of medicinal chemistry 59 (4), 1634-1641, 2016 | 95 | 2016 |
| Heteronuclear NMR and Soft Docking: An Experimental Approach for a Structural Model of the Cytochrome c553−Ferredoxin Complex X Morelli, A Dolla, M Czjzek, PN Palma, F Blasco, L Krippahl, JJG Moura, ... Biochemistry 39 (10), 2530-2537, 2000 | 86 | 2000 |
| 2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions MJ Basse, S Betzi, X Morelli, P Roche Database 2016, baw007, 2016 | 78 | 2016 |
| GFscore: a general nonlinear consensus scoring function for high-throughput docking S Betzi, K Suhre, B Chétrit, F Guerlesquin, X Morelli Journal of chemical information and modeling 46 (4), 1704-1712, 2006 | 71 | 2006 |
| Molecular mapping of the RNA Cap 2′-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16 A Lugari, S Betzi, E Decroly, E Bonnaud, A Hermant, JC Guillemot, ... Journal of Biological Chemistry 285 (43), 33230-33241, 2010 | 68 | 2010 |
| A novel approach for assesing macromolecular complexes combining soft‐docking calculations with NMR data XJ Morelli, PN Palma, F Guerlesquin, AC Rigby Protein Science 10 (10), 2131-2137, 2001 | 68 | 2001 |
| Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity C Salmi-Smail, A Fabre, F Dequiedt, A Restouin, R Castellano, S Garbit, ... Journal of medicinal chemistry 53 (8), 3038-3047, 2010 | 65 | 2010 |
| Integrated strategy for lead optimization based on fragment growing: the diversity-oriented-target-focused-synthesis approach L Hoffer, YV Voitovich, B Raux, K Carrasco, C Muller, AY Fedorov, ... Journal of medicinal chemistry 61 (13), 5719-5732, 2018 | 59 | 2018 |
| Structural Model of the Fe-Hydrogenase/Cytochromec 553 Complex Combining Transverse Relaxation-optimized Spectroscopy Experiments and Soft Docking Calculations X Morelli, M Czjzek, CE Hatchikian, O Bornet, JC Fontecilla-Camps, ... Journal of Biological Chemistry 275 (30), 23204-23210, 2000 | 58 | 2000 |
| Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR C Bernard, S Gely, JM Bourhis, X Morelli, S Longhi, H Darbon FEBS letters 583 (7), 1084-1089, 2009 | 50 | 2009 |
| Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130 F Hu, X Shi, B Li, X Huang, X Morelli, N Shi Journal of Biological Chemistry 290 (44), 26373-26382, 2015 | 49 | 2015 |
| Structural basis for the interaction between Golgi reassembly-stacking protein GRASP55 and Golgin45 J Zhao, B Li, X Huang, X Morelli, N Shi Journal of Biological Chemistry 292 (7), 2956-2965, 2017 | 47 | 2017 |
| 2P2IHUNTER: a tool for filtering orthosteric protein–protein interaction modulators via a dedicated support vector machine V Hamon, R Bourgeas, P Ducrot, I Theret, L Xuereb, MJ Basse, JM Brunel, ... Journal of The Royal Society Interface 11 (90), 20130860, 2014 | 45 | 2014 |
| Chemistry‐driven hit‐to‐lead optimization guided by structure‐based approaches L Hoffer, C Muller, P Roche, X Morelli Molecular Informatics 37 (9-10), 1800059, 2018 | 44 | 2018 |
Laurent HofferCancer Research Centre of Marseille (CRCM)在 inserm.fr 的电子邮件经过验证
