Ipomoeassin F binds Sec61α to inhibit protein translocation G Zong, Z Hu, S O’keefe, D Tranter, MJ Iannotti, L Baron, B Hall, ... Journal of the American Chemical Society 141 (21), 8450-8461, 2019 | 69 | 2019 |
Eeyarestatin compounds selectively enhance Sec61-mediated Ca2+ leakage from the endoplasmic reticulum I Gamayun, S O'Keefe, T Pick, MC Klein, D Nguyen, C McKibbin, ... Cell chemical biology 26 (4), 571-583. e6, 2019 | 48 | 2019 |
An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum S O’keefe, G Zong, KB Duah, LE Andrews, WQ Shi, S High Communications Biology 4 (1), 828, 2021 | 39 | 2021 |
Membrane protein biogenesis at the ER: the highways and byways S O'Keefe, MR Pool, S High The FEBS Journal 289 (22), 6835-6862, 2022 | 34 | 2022 |
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor S O'Keefe, P Roboti, KB Duah, G Zong, H Schneider, WQ Shi, S High Journal of Cell Science 134 (4), jcs257758, 2021 | 28 | 2021 |
Characterizing the selectivity of ER α-glucosidase inhibitors S O’Keefe, QP Roebuck, I Nakagome, S Hirono, A Kato, R Nash, S High Glycobiology 29 (7), 530-542, 2019 | 21 | 2019 |
Ring expansion leads to a more potent analogue of Ipomoeassin F G Zong, Z Hu, KB Duah, LE Andrews, J Zhou, S O’Keefe, L Whisenhunt, ... The Journal of organic chemistry 85 (24), 16226-16235, 2020 | 19 | 2020 |
Membrane translocation at the ER: with a little help from my friends S O'Keefe, S High The FEBS Journal 287 (21), 4607-4611, 2020 | 13 | 2020 |
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity H Stewart, Y Lu, S O’Keefe, A Valpadashi, LD Cruz-Zaragoza, HA Michel, ... Iscience 26 (11), 2023 | 10 | 2023 |
Eeyarestatin 24 impairs SecYEG‐dependent protein trafficking and inhibits growth of clinically relevant pathogens M Steenhuis, GM Koningstein, J Oswald, T Pick, S O’Keefe, HG Koch, ... Molecular Microbiology 115 (1), 28-40, 2021 | 10 | 2021 |
Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting A Tirincsi, S O’Keefe, D Nguyen, M Sicking, J Dudek, F Förster, M Jung, ... Cells 11 (18), 2925, 2022 | 8 | 2022 |
Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis P Roboti, S O’Keefe, KB Duah, WQ Shi, S High Scientific Reports 11 (1), 11562, 2021 | 8 | 2021 |
Dual action of eeyarestatin 24 on sec-dependent protein secretion and bacterial DNA AB Schäfer, M Steenhuis, KK Jim, J Neef, S O’Keefe, RC Whitehead, ... ACS infectious diseases 9 (2), 253-269, 2023 | 6 | 2023 |
Biochemical and biological assays of mycolactone-mediated inhibition of Sec61 S O’Keefe, S High, C Demangel Mycobacterium Ulcerans: Methods and Protocols, 163-181, 2022 | 5 | 2022 |
Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F S O’Keefe, P Bhadra, KB Duah, G Zong, L Tenay, L Andrews, ... Molecules 27 (14), 4419, 2022 | 1 | 2022 |
Small molecule inhibitors targeting protein biogenesis at the endoplasmic reticulum S O'Keefe PQDT-Global, 2019 | 1 | 2019 |
Erratum: Characterizing the selectivity of ER α-glucosidase inhibitors (Glycobiology (2019) 29: 7 (530-542 S O'Keefe, QP Roebuck, I Nakagome, S Hirono, A Kato, R Nash, S High Glycobiology 33 (6), 525, 2023 | | 2023 |
Biology-directed and in silico-aided design liberates a potent, simplified and ipomoeassin-F-derived Sec61 inhibitor S O'Keefe, P Bhadra, K Duah, G Zong, L Tenay, L Andrews, H Schneider, ... | | 2022 |
The road less travelled: membrane protein biogenesis at the ER S O'Keefe Microbiology, 2021 | | 2021 |
Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis J Chang, A Pickard, JA Herrera, S O’Keefe, M Hartshorn, R Garva, ... bioRxiv, 2021.03. 25.436925, 2021 | | 2021 |