Experimental models of foamy macrophages and approaches for dissecting the mechanisms of lipid accumulation and consumption during dormancy and reactivation of tuberculosis P Santucci, F Bouzid, N Smichi, I Poncin, L Kremer, C De Chastellier, ... Frontiers in cellular and infection microbiology 6, 122, 2016 | 60 | 2016 |
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide P Santucci, DJ Greenwood, A Fearns, K Chen, H Jiang, MG Gutierrez Nature Communications 12 (1), 3816, 2021 | 57 | 2021 |
M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion EM Bernard, A Fearns, C Bussi, P Santucci, CJ Peddie, RJ Lai, ... Journal of cell science 134 (5), jcs252973, 2021 | 44 | 2021 |
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria P Santucci, MD Johansen, V Point, I Poncin, A Viljoen, JF Cavalier, ... Scientific reports 9 (1), 8667, 2019 | 43 | 2019 |
Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases PC Nguyen, A Madani, P Santucci, BP Martin, RR Paudel, S Delattre, ... International journal of antimicrobial agents 51 (4), 651-654, 2018 | 30 | 2018 |
Delineating the physiological roles of the PE and catalytic domains of LipY in lipid consumption in Mycobacterium-infected foamy macrophages P Santucci, S Diomandé, I Poncin, L Alibaud, A Viljoen, L Kremer, ... Infection and immunity 86 (9), 10.1128/iai. 00394-18, 2018 | 28 | 2018 |
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism C Bussi, T Heunis, E Pellegrino, EM Bernard, N Bah, MS Dos Santos, ... Nature Communications 13 (1), 7338, 2022 | 26 | 2022 |
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling P Santucci, V Point, I Poncin, A Guy, C Crauste, C Serveau-Avesque, ... Bioscience reports 38 (6), BSR20181953, 2018 | 26 | 2018 |
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages B Aylan, EM Bernard, E Pellegrino, L Botella, A Fearns, N Athanasiadi, ... Nature Microbiology 8 (5), 803-818, 2023 | 24 | 2023 |
Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis? I Mallick, P Santucci, I Poncin, V Point, L Kremer, JF Cavalier, S Canaan FEMS Microbiology Reviews 45 (6), fuab029, 2021 | 18 | 2021 |
Synthesis of long‐chain β‐lactones and their antibacterial activities against pathogenic mycobacteria P Santucci, C Dedaki, A Athanasoulis, L Gallorini, A Munoz, S Canaan, ... ChemMedChem 14 (3), 349-358, 2019 | 16 | 2019 |
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains P Santucci, N Smichi, S Diomandé, I Poncin, V Point, H Gaussier, ... The FEBS journal 286 (16), 3164-3181, 2019 | 15 | 2019 |
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis P Santucci, B Aylan, L Botella, EM Bernard, C Bussi, E Pellegrino, ... Mbio 13 (2), e00117-22, 2022 | 13 | 2022 |
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages E Pellegrino, B Aylan, C Bussi, A Fearns, EM Bernard, N Athanasiadi, ... Journal of Cell Biology 222 (12), 2023 | 10 | 2023 |
Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage V Guerrini, S Subbian, P Santucci, S Canaan, ML Gennaro, G Pozzi PloS one 11 (12), e0167989, 2016 | 8 | 2016 |
Host cell environments and antibiotic efficacy in tuberculosis NJ Day, P Santucci, MG Gutierrez Trends in Microbiology, 2023 | 4 | 2023 |
High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages B Aylan, L Botella, MG Gutierrez, P Santucci FEBS Open Bio 13 (7), 1204-1217, 2023 | 3 | 2023 |
Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model TTH Le, C Kellenberger, M Boyer, P Santucci, N Flaugnatti, E Cascales, ... International Journal of Molecular Sciences 24 (2), 1740, 2023 | 3 | 2023 |
Lipid droplets breakdown: adipose triglyceride lipase leads the way P Santucci, S Canaan Current Protein and Peptide Science 19 (11), 1131-1133, 2018 | 3 | 2018 |
Intracellular pathogens, membrane damage and cytosolic access P Santucci Cellular Microbiology 23 (4), e13296, 2021 | 2 | 2021 |