| Deconstruction of iterative multidomain polyketide synthase function JM Crawford, PM Thomas, JR Scheerer, AL Vagstad, NL Kelleher, ... Science 320 (5873), 243-246, 2008 | 252 | 2008 |
| Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization JM Crawford, TP Korman, JW Labonte, AL Vagstad, EA Hill, ... Nature 461 (7267), 1139-1143, 2009 | 215 | 2009 |
| Radical S‐Adenosyl Methionine Epimerases: Regioselective Introduction of Diverse D‐Amino Acid Patterns into Peptide Natural Products BI Morinaka, AL Vagstad, MJ Helf, M Gugger, C Kegler, MF Freeman, ... Angewandte Chemie International Edition 53 (32), 8503-8507, 2014 | 131 | 2014 |
| Metalloregulation of yeast membrane steroid receptor homologs TJ Lyons, NY Villa, LM Regalla, BR Kupchak, A Vagstad, DJ Eide Proceedings of the National Academy of Sciences 101 (15), 5506-5511, 2004 | 121 | 2004 |
| Natural noncanonical protein splicing yields products with diverse β-amino acid residues BI Morinaka, E Lakis, M Verest, MJ Helf, T Scalvenzi, AL Vagstad, J Sims, ... Science 359 (6377), 779-782, 2018 | 109 | 2018 |
| Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis AS Byer, H Yang, EC McDaniel, V Kathiresan, S Impano, A Pagnier, ... Journal of the American Chemical Society 140 (28), 8634-8638, 2018 | 95 | 2018 |
| Polyketide proofreading by an acyltransferase-like enzyme K Jensen, H Niederkrüger, K Zimmermann, AL Vagstad, J Moldenhauer, ... Chemistry & biology 19 (3), 329-339, 2012 | 72 | 2012 |
| Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming AG Newman, AL Vagstad, PA Storm, CA Townsend Journal of the American Chemical Society 136 (20), 7348-7362, 2014 | 67 | 2014 |
| Starter unit specificity directs genome mining of polyketide synthase pathways in fungi JM Crawford, AL Vagstad, KC Ehrlich, CA Townsend Bioorganic chemistry 36 (1), 16-22, 2008 | 65 | 2008 |
| Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’bacteria MF Freeman, AL Vagstad, J Piel Current opinion in chemical biology 31, 8-14, 2016 | 64 | 2016 |
| Landornamides: antiviral ornithine‐containing ribosomal peptides discovered through genome mining NM Bösch, M Borsa, U Greczmiel, BI Morinaka, M Gugger, A Oxenius, ... Angewandte Chemie International Edition 59 (29), 11763-11768, 2020 | 58 | 2020 |
| Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis AL Vagstad, EA Hill, JW Labonte, CA Townsend Chemistry & biology 19 (12), 1525-1534, 2012 | 57 | 2012 |
| Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity AL Vagstad, SB Bumpus, K Belecki, NL Kelleher, CA Townsend Journal of the American Chemical Society 134 (15), 6865-6877, 2012 | 57 | 2012 |
| Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical “Starter Unit Effect” JM Crawford, AL Vagstad, KP Whitworth, CA Townsend, KC Ehrlich Chembiochem: a European journal of chemical biology 9 (7), 1019, 2008 | 54 | 2008 |
| Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function AG Newman, AL Vagstad, K Belecki, JR Scheerer, CA Townsend Chemical Communications 48 (96), 11772-11774, 2012 | 53 | 2012 |
| Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA CR Huitt-Roehl, EA Hill, MM Adams, AL Vagstad, JW Li, CA Townsend ACS chemical biology 10 (6), 1443-1449, 2015 | 52 | 2015 |
| Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products AL Vagstad, AG Newman, PA Storm, K Belecki, JM Crawford, ... Angewandte Chemie (International ed. in English) 52 (6), 2013 | 47 | 2013 |
| Ribosomally derived lipopeptides containing distinct fatty acyl moieties F Hubrich, NM Bösch, C Chepkirui, BI Morinaka, M Rust, M Gugger, ... Proceedings of the National Academy of Sciences 119 (3), e2113120119, 2022 | 44 | 2022 |
| Introduction of d‐Amino Acids in Minimalistic Peptide Substrates by an S‐Adenosyl‐l‐Methionine Radical Epimerase AL Vagstad, T Kuranaga, S Püntener, VR Pattabiraman, JW Bode, J Piel Angewandte Chemie International Edition 58 (8), 2246-2250, 2019 | 41 | 2019 |
| Probing the selectivity and protein⋅ protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers J Bruegger, B Haushalter, A Vagstad, G Shakya, N Mih, CA Townsend, ... Chemistry & biology 20 (9), 1135-1146, 2013 | 37 | 2013 |
