| The revolution continues: newly discovered systems expand the CRISPR-Cas toolkit K Murugan, K Babu, R Sundaresan, R Rajan, DG Sashital Molecular cell 68 (1), 15-25, 2017 | 214 | 2017 |
| Structural studies of type I topoisomerases NM Baker, R Rajan, A Mondragón Nucleic acids research 37 (3), 693-701, 2009 | 146 | 2009 |
| Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis EJ Sontheimer, Y Zhang, A Mondragon, R Rajan, J Thomson, ... | 132 | 2014 |
| Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase G Shen, R Rajan, J Zhu, CE Bell, D Pei Journal of medicinal chemistry 49 (10), 3003-3011, 2006 | 100 | 2006 |
| RNA-independent DNA cleavage activities of Cas9 and Cas12a R Sundaresan, HP Parameshwaran, SD Yogesha, MW Keilbarth, R Rajan Cell reports 21 (13), 3728-3739, 2017 | 88 | 2017 |
| DNase H activity of Neisseria meningitidis Cas9 Y Zhang, R Rajan, HS Seifert, A Mondragón, EJ Sontheimer Molecular cell 60 (2), 242-255, 2015 | 87 | 2015 |
| Crystal structure of RecA from Deinococcus radiodurans: insights into the structural basis of extreme radioresistance R Rajan, CE Bell Journal of molecular biology 344 (4), 951-963, 2004 | 82 | 2004 |
| Crystal Structure of S-Ribosylhomocysteinase (LuxS) in Complex with a Catalytic 2-Ketone Intermediate, R Rajan, J Zhu, X Hu, D Pei, CE Bell Biochemistry 44 (10), 3745-3753, 2005 | 74 | 2005 |
| The CRISPR-Cas mechanism for adaptive immunity and alternate bacterial functions fuels diverse biotechnologies S Newsom, HP Parameshwaran, L Martin, R Rajan Frontiers in cellular and infection microbiology 10, 619763, 2021 | 62 | 2021 |
| Probing the Catalytic Mechanism of S-Ribosylhomocysteinase (LuxS) with Catalytic Intermediates and Substrate Analogues B Gopishetty, J Zhu, R Rajan, AJ Sobczak, SF Wnuk, CE Bell, D Pei Journal of the American Chemical Society 131 (3), 1243-1250, 2009 | 58 | 2009 |
| Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain Z Zuo, A Zolekar, K Babu, VJT Lin, HS Hayatshahi, R Rajan, YC Wang, ... Elife 8, e46500, 2019 | 29 | 2019 |
| Bridge helix of Cas9 modulates target DNA cleavage and mismatch tolerance K Babu, N Amrani, W Jiang, SD Yogesha, R Nguyen, PZ Qin, R Rajan Biochemistry 58 (14), 1905-1917, 2019 | 27 | 2019 |
| Probing the DNA sequence specificity of Escherichia coli RECA protein R Rajan, JW Wisler, CE Bell Nucleic acids research 34 (8), 2463-2471, 2006 | 25 | 2006 |
| Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs CW Chan, D Badong, R Rajan, A Mondragón Rna 26 (3), 278-289, 2020 | 17 | 2020 |
| Nucleic acid-dependent conformational changes in CRISPR–Cas9 revealed by site-directed spin labeling C Vazquez Reyes, NS Tangprasertchai, SD Yogesha, RH Nguyen, ... Cell biochemistry and biophysics 75, 203-210, 2017 | 17 | 2017 |
| Coordinated actions of Cas9 HNH and RuvC nuclease domains are regulated by the bridge helix and the target DNA sequence K Babu, V Kathiresan, P Kumari, S Newsom, HP Parameshwaran, X Chen, ... Biochemistry 60 (49), 3783-3800, 2021 | 15 | 2021 |
| Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis N Wakefield, R Rajan, EJ Sontheimer FEBS letters 589 (20), 3197-3204, 2015 | 15 | 2015 |
| CRISPR-Cas12a nucleases bind flexible DNA duplexes without RNA/DNA complementarity W Jiang, J Singh, A Allen, Y Li, V Kathiresan, O Qureshi, ... ACS omega 4 (17), 17140-17147, 2019 | 14 | 2019 |
| Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding R Rajan, B Taneja, A Mondragón Structure 18 (7), 829-838, 2010 | 13 | 2010 |
| Rational engineering of CRISPR-Cas9 nuclease to attenuate position-dependent off-target effects Z Zuo, K Babu, C Ganguly, A Zolekar, S Newsom, R Rajan, YC Wang, ... The CRISPR journal 5 (2), 329-340, 2022 | 12 | 2022 |
