| A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity JB Bramsen, MB Laursen, AF Nielsen, TB Hansen, C Bus, N Langkjær, ... Nucleic acids research 37 (9), 2867-2881, 2009 | 446 | 2009 |
| Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals MA Campbell, J Wengel Chemical Society Reviews 40 (12), 5680-5689, 2011 | 305 | 2011 |
| A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects JB Bramsen, MM Pakula, TB Hansen, C Bus, N Langkjær, D Odadzic, ... Nucleic acids research 38 (17), 5761-5773, 2010 | 208 | 2010 |
| UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability N Langkjær, A Pasternak, J Wengel Bioorganic & medicinal chemistry 17 (15), 5420-5425, 2009 | 160 | 2009 |
| Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an … K Fluiter, ORF Mook, J Vreijling, N Langkjær, T Højland, J Wengel, F Baas Molecular BioSystems 5 (8), 838-843, 2009 | 71 | 2009 |
| Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE H Thisgaard, J Kumlin, N Langkjær, J Chua, B Hook, M Jensen, ... EJNMMI radiopharmacy and chemistry 6, 1-11, 2021 | 48 | 2021 |
| Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies TB Jensen, N Langkjær, J Wengel Nucleic Acids Symposium Series 52 (1), 133-134, 2008 | 39 | 2008 |
| Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule LJ Aaldering, V Poongavanam, N Langkjær, NA Murugan, PT Jørgensen, ... ChemBioChem 18 (8), 755-763, 2017 | 31 | 2017 |
| Highly effective auger-electron therapy in an orthotopic glioblastoma xenograft model using convection-enhanced delivery H Thisgaard, B Halle, C Aaberg-Jessen, BB Olsen, ASN Therkelsen, ... Theranostics 6 (12), 2278, 2016 | 28 | 2016 |
| Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin … S Holmboe, PL Hansen, H Thisgaard, I Block, C Müller, N Langkjaer, ... PLoS One 12 (5), e0178286, 2017 | 24 | 2017 |
| Synthesis and biophysical studies of coronene functionalized 2′-amino-LNA: A novel class of fluorescent nucleic acids P Gupta, N Langkjær, J Wengel Bioconjugate chemistry 21 (3), 513-520, 2010 | 23 | 2010 |
| 3′-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes M Ejlersen, N Langkjær, J Wengel Organic & Biomolecular Chemistry 15 (9), 2073-2085, 2017 | 11 | 2017 |
| GMP production of 6-[18F]Fluoro-l-DOPA for PET/CT imaging by different synthetic routes: a three center experience VL Andersen, MA Soerensen, JH Dam, N Langkjaer, H Petersen, ... EJNMMI radiopharmacy and chemistry 6 (1), 21, 2021 | 9 | 2021 |
| Watson–Crick hydrogen bonding of unlocked nucleic acids N Langkjær, J Wengel, A Pasternak Bioorganic & Medicinal Chemistry Letters 25 (22), 5064-5066, 2015 | 9 | 2015 |
| Bis‐Pyrene‐Modified Unlocked Nucleic Acids: Synthesis, Hybridization Studies, and Fluorescent Properties P Perlíková, M Ejlersen, N Langkjær, J Wengel ChemMedChem 9 (9), 2120-2127, 2014 | 9 | 2014 |
| Auger electron therapy of glioblastoma using [125I] 5-iodo-2′-deoxyuridine and concomitant chemotherapy–Evaluation of a potential treatment strategy KL Madsen, ASN Therkelsen, N Langkjær, BB Olsen, H Thisgaard Nuclear Medicine and Biology 96, 35-40, 2021 | 7 | 2021 |
| Selective Biocatalytic Acylation Studies on 5′-O-(4,4′-Dimethoxytrityl)-2′,3′-Secouridine: An Efficient Synthesis of UNA Monomer SK Singh, LC Reddy, S Srivastava, CE Olsen, YS Sanghvi, N Langkjær, ... Nucleosides, Nucleotides and Nucleic Acids 31 (12), 831-840, 2012 | 6 | 2012 |
| A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and viral replication M Tuttolomondo, STD Pham, MG Terp, VC Castillo, N Kalisi, S Vogel, ... Molecular Therapy-Nucleic Acids, 2024 | 3 | 2024 |
| Preparation and Evaluation of [18F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC JH Dam, N Langkjær, C Baun, BB Olsen, AY Nielsen, H Thisgaard Molecules 27 (20), 6818, 2022 | 3 | 2022 |
| A randomised trial of [18F]PSMA‐1007‐PET/CT versus NaF‐PET/CT for staging primary prostate cancer: A trial protocol KM Buch‐Olsen, MH Poulsen, S Hansen, MH Vilstrup, J Holm, S Hess, ... BJUI compass 4 (5), 513-522, 2023 | 1 | 2023 |
Helge ThisgaardAssociate Professor of Nuclear Medicine, University of Southern Denmark在 rsyd.dk 的电子邮件经过验证
