Connective tissue growth factor: from molecular understandings to drug discovery Z Chen, N Zhang, HY Chu, Y Yu, ZK Zhang, G Zhang, BT Zhang Frontiers in cell and developmental biology 8, 593269, 2020 | 110 | 2020 |
Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation Y Yu, L Wang, S Ni, D Li, J Liu, HY Chu, N Zhang, M Sun, N Li, Q Ren, ... Nature communications 13 (1), 4241, 2022 | 78 | 2022 |
Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice L Wang, Y Yu, S Ni, D Li, J Liu, D Xie, HY Chu, Q Ren, C Zhong, N Zhang, ... Theranostics 12 (13), 5645, 2022 | 54 | 2022 |
Structural biology for the molecular insight between aptamers and target proteins N Zhang, Z Chen, D Liu, H Jiang, ZK Zhang, A Lu, BT Zhang, Y Yu, ... International Journal of Molecular Sciences 22 (8), 4093, 2021 | 50 | 2021 |
Pros and cons of denosumab treatment for osteoporosis and implication for RANKL aptamer therapy N Zhang, ZK Zhang, Y Yu, Z Zhuo, G Zhang, BT Zhang Frontiers in Cell and Developmental Biology 8, 325, 2020 | 49 | 2020 |
Current pharmacological strategies for Duchenne muscular dystrophy S Yao, Z Chen, Y Yu, N Zhang, H Jiang, G Zhang, Z Zhang, B Zhang Frontiers in Cell and Developmental Biology 9, 689533, 2021 | 41 | 2021 |
Drug discovery of sclerostin inhibitors S Yu, D Li, N Zhang, S Ni, M Sun, L Wang, H Xiao, D Liu, J Liu, Y Yu, ... Acta Pharmaceutica Sinica B 12 (5), 2150-2170, 2022 | 27 | 2022 |
Characterization and analysis of a novel diguanylate cyclase PA0847 from Pseudomonas aeruginosa PAO1 Y Zhang, J Guo, N Zhang, W Yuan, Z Lin, W Huang Infection and drug resistance, 655-665, 2019 | 19 | 2019 |
From EST to novel spider silk gene identification for production of spidroin-based biomaterials W Huang, Y Zhang, Y Chen, Y Wang, W Yuan, N Zhang, TJ Lam, Z Gong, ... Scientific Reports 7 (1), 13354, 2017 | 11 | 2017 |
Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily N Zhang, W Yuan, JS Fan, Z Lin Scientific Reports 7 (1), 7073, 2017 | 10 | 2017 |
Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains N Zhang, L Kisiswa, A Ramanujan, Z Li, EW Sim, X Tian, W Yuan, ... Journal of Biological Chemistry 297 (2), 2021 | 9 | 2021 |
Sclerostin loop3: a potential target for developing a next generation sclerostin inhibitor for bone anabolic therapy with low cardiovascular concern Y Yu, L Wang, S Ni, Z Zhuo, HY Chu, N Zhang, D Li, J Liu, A Lyu, ... JOURNAL OF BONE AND MINERAL RESEARCH 35, 252-252, 2020 | 3 | 2020 |
1H, 15N and 13C chemical shift assignments of the C-terminal domain of TRADD N Zhang, W Yuan, JS Fan, Z Lin Biomolecular NMR Assignments 11, 281-284, 2017 | 3 | 2017 |
Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1 N Zhang, P Yang, Y Li, Q Ouyang, F Hou, G Zhu, B Zhang, J Huang, J Jia, ... Journal of Clinical and Translational Hepatology 12 (3), 227, 2024 | 1 | 2024 |
Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential A Gubu, Y Ma, S Yu, H Zhang, Z Chen, S Ni, R Abdullah, H Xiao, Y Zhang, ... Molecular Therapy. Nucleic Acids 35 (1), 2024 | 1 | 2024 |
Structural insights of the toxin-antitoxin system VPA0770-VPA0769 in Vibrio parahaemolyticus Y Zhang, X Song, C Chen, L Liu, Y Xu, N Zhang, W Huang, J Zheng, ... International Journal of Biological Macromolecules 242, 124755, 2023 | 1 | 2023 |
Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Suppressing Inflammatory Responses L Wang, N Zhang, J Liu, X Yang, Y Yu, D Li, H Jiang, M Sun, LI Nanxi, ... Metabolism-Clinical and Experimental 142, 2023 | 1 | 2023 |
The Role of Sclerostin in Lipid and Glucose Metabolism Disorders H Jiang, D Li, Y Han, N Li, X Tao, J Liu, Z Zhang, Y Yu, L Wang, S Yu, ... Biochemical Pharmacology, 115694, 2023 | | 2023 |
Sclerostin loop3-LRP4 Interaction Required by Sclerostin for Lipid and Glucose Metabolism Impairment in Adipocyte H Jiang, D Li, L Wang, N Zhang, S Yu, H Zhang, J Liu, D Ma, A Lu, ... Metabolism-Clinical and Experimental 142, 2023 | | 2023 |
Sclerostin Loop3 Participates in Whole-body Lipid and Glucose Metabolism Impairment Effects of Sclerostin D Li, H Jiang, L Wang, N Zhang, S Yu, H Zhang, N Li, J Liu, D Ma, A Lu, ... Metabolism-Clinical and Experimental 142, 2023 | | 2023 |