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Wei Yang
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Immunogenic neoantigens derived from gene fusions stimulate T cell responses.
Wei Yang, Ken-Wing Lee, Raghvendra M. Srivastava
Nature Medicine 25, 767–775, 2019
3222019
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer
LM Dillon, JR Bean, W Yang, K Shee, LK Symonds, JM Balko, ...
Oncogene 34 (30), 3968-3976, 2015
862015
Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer
K Shee, W Yang, JW Hinds, RA Hampsch, FS Varn, NA Traphagen, ...
Journal of Experimental Medicine 215 (3), 895-910, 2018
702018
Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells
H Zhu, W Yang, L He, W Ding, L Zheng, S Liao, P Huang, W Lu, Q He, ...
PloS one 7 (12), e52333, 2012
592012
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity
X Ma, N Riaz, RM Samstein, M Lee, V Makarov, C Valero, D Chowell, ...
Nature genetics 54 (7), 996-1012, 2022
422022
GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1
L Zheng, W Yang, C Zhang, W Ding, H Zhu, N Lin, H Wu, Q He, B Yang
Cancer letters 309 (1), 27-36, 2011
422011
Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer
W Yang, SR Hosford, LM Dillon, K Shee, SC Liu, JR Bean, L Salphati, ...
Clinical Cancer Research 22 (9), 2250-2260, 2016
362016
Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
A Poole, V Karuppiah, A Hartt, JN Haidar, S Moureau, T Dobrzycki, ...
Nature communications 13 (1), 5333, 2022
352022
Combined inhibition of both p110α and p110β isoforms of phosphatidylinositol 3-kinase is required for sustained therapeutic effect in PTEN-deficient, ER+ breast cancer
SR Hosford, LM Dillon, SJ Bouley, R Rosati, W Yang, VS Chen, ...
Clinical Cancer Research 23 (11), 2795-2805, 2017
312017
Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor–positive breast cancer
W Yang, SR Hosford, NA Traphagen, K Shee, E Demidenko, S Liu, ...
The FASEB Journal 32 (3), 1222, 2018
272018
Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer
W Yang, GN Schwartz, JD Marotti, V Chen, NA Traphagen, J Gui, ...
Oncotarget 9 (10), 8810, 2018
212018
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer
JR Bean, SR Hosford, LK Symonds, P Owens, LM Dillon, W Yang, K Shee, ...
Breast cancer research and treatment 149, 69-79, 2015
172015
Immunomodulatory and immunotherapeutic implications of tobacco smoking in squamous cell carcinomas and normal airway epithelium
Jingming Wang, Maximilian Linxweiler, Wei Yang, Timothy Chan, Luc Morris
Oncotarget 10, 3835-3839, 2019
112019
Nutlin-1 strengthened anti-proliferation and differentiation-inducing activity of ATRA in ATRA-treated p-glycoprotein deregulated human myelocytic leukemia cells
L Zhang, Y Yan, D Zhu, W Yang, W Wang, Y Hu, B Yang, Q He
Investigational new drugs 30, 37-47, 2012
102012
A transcriptionally definable subgroup of triple-negative breast and ovarian cancer samples shows sensitivity to HSP90 inhibition
K Shee, JD Wells, M Ung, RA Hampsch, NA Traphagen, W Yang, SC Liu, ...
Clinical Cancer Research 26 (1), 159-170, 2020
32020
Bleeding with concomitant ibrutinib and oral anticoagulant therapy: A population-based cohort study
N Dhopeshwarkar, W Yang, S Hennessy, JM Rhodes, A Cuker, ...
American journal of hematology 98 (3), E49, 2023
12023
Panel-based estimates of tumor mutational burden: characterizing unknown unknowns
W Yang, LGT Morris, TA Chan
Annals of Oncology 30 (9), 1413-1415, 2019
12019
Abstract PD4-08: a microenvironment secretome screen reveals FGF2 as a mediator of resistance to anti-estrogens and PI3K/mTOR pathway inhibitors in ER+ breast cancer
K Shee, JW Hinds, W Yang, RA Hampsch, K Patel, FS Varn, C Cheng, ...
Cancer Research 78 (4_Supplement), PD4-08-PD4-08, 2018
12018
A microenvironment secretome screen reveals FGF2 as a mediator of resistance to anti-estrogens and PI3K/mTOR pathway inhibitors in ER plus breast cancer
K Shee, JW Hinds, W Yang, RA Hampsch, K Patel, FS Varn, C Cheng, ...
Cancer Research 78 (4), 2018
12018
Combining Super Learner with high‐dimensional propensity score to improve confounding adjustment: A real‐world application in chronic lymphocytic leukemia
N Dhopeshwarkar, W Yang, S Hennessy, JM Rhodes, A Cuker, ...
Pharmacoepidemiology and Drug Safety 33 (1), e5678, 2024
2024
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