Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations A Singanayagam, N Glanville, JL Girkin, YM Ching, A Marcellini, ... Nature communications 9 (1), 2229, 2018 | 186 | 2018 |
Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis DW Waters, KEC Blokland, PS Pathinayake, JK Burgess, SE Mutsaers, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 315 (2 …, 2018 | 150 | 2018 |
Innate immunity and immune evasion by enterovirus 71 PS Pathinayake, ACY Hsu, PAB Wark Viruses 7 (12), 6613-6630, 2015 | 93 | 2015 |
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma PAB Wark, PS Pathinayake, G Kaiko, K Nichol, A Ali, L Chen, EN Sutanto, ... Respirology 26 (5), 442-451, 2021 | 83 | 2021 |
STAT3 regulates the onset of oxidant-induced senescence in lung fibroblasts DW Waters, KEC Blokland, PS Pathinayake, L Wei, M Schuliga, J Jaffar, ... American journal of respiratory cell and molecular biology 61 (1), 61-73, 2019 | 67 | 2019 |
Antiviral immunity is impaired in COPD patients with frequent exacerbations A Singanayagam, SL Loo, M Calderazzo, LJ Finney, MB Trujillo Torralbo, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 317 (6 …, 2019 | 65 | 2019 |
Single-stranded DNA aptamer that specifically binds to the influenza virus NS1 protein suppresses interferon antagonism HM Woo, KS Kim, JM Lee, HS Shim, SJ Cho, WK Lee, HW Ko, YS Keum, ... Antiviral Research 100 (2), 337-345, 2013 | 59 | 2013 |
Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma MK Ali, RY Kim, AC Brown, JR Mayall, R Karim, JW Pinkerton, G Liu, ... European Respiratory Journal 55 (4), 2020 | 54 | 2020 |
Understanding the unfolded protein response in the pathogenesis of asthma PS Pathinayake, ACY Hsu, DW Waters, PM Hansbro, LG Wood, ... Frontiers in immunology 9, 175, 2018 | 50 | 2018 |
Mucosal Vaccination with Recombinant Lactobacillus casei-Displayed CTA1-Conjugated Consensus Matrix Protein-2 (sM2) Induces Broad Protection against … MYE Chowdhury, R Li, JH Kim, ME Park, TH Kim, P Pathinayake, ... PLoS One 9 (4), e94051, 2014 | 47 | 2014 |
The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders WC Chong, MD Shastri, GM Peterson, RP Patel, PS Pathinayake, K Dua, ... Clinical & translational immunology 10 (2), e1247, 2021 | 42 | 2021 |
SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro ACY Hsu, G Wang, AT Reid, PC Veerati, PS Pathinayake, K Daly, ... Biorxiv, 2020.09. 30.317818, 2020 | 42 | 2020 |
Mucosally administered Lactobacillus surface-displayed influenza antigens (sM2 and HA2) with cholera toxin subunit A1 (CTA1) Induce broadly protective immune responses against … R Li, MYE Chowdhury, JH Kim, TH Kim, P Pathinayake, WS Koo, ME Park, ... Veterinary microbiology 179 (3-4), 250-263, 2015 | 39 | 2015 |
Respiratory viruses and asthma PAB Wark, JM Ramsahai, P Pathinayake, B Malik, NW Bartlett Seminars in Respiratory and Critical Care Medicine 39 (01), 045-055, 2018 | 38 | 2018 |
Rubicon modulates antiviral type I interferon (IFN) signaling by targeting IFN regulatory factor 3 dimerization JH Kim, TH Kim, HC Lee, C Nikapitiya, MB Uddin, ME Park, ... Journal of virology 91 (14), 10.1128/jvi. 00248-17, 2017 | 34 | 2017 |
Increased SARS-CoV-2 infection, protease, and inflammatory responses in chronic obstructive pulmonary disease primary bronchial epithelial cells defined with single-cell RNA … MD Johansen, RM Mahbub, S Idrees, DH Nguyen, S Miemczyk, ... American Journal of Respiratory and Critical Care Medicine 206 (6), 712-729, 2022 | 26 | 2022 |
Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma PS Pathinayake, DW Waters, KS Nichol, AC Brown, AT Reid, ACY Hsu, ... Thorax 77 (5), 443-451, 2022 | 21 | 2022 |
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi LLY Chan, DE Anderson, HS Cheng, FX Ivan, S Chen, AEZ Kang, R Foo, ... Nature Communications 13 (1), 7635, 2022 | 16 | 2022 |
A senescence bystander effect in human lung fibroblasts DW Waters, M Schuliga, PS Pathinayake, L Wei, HY Tan, KEC Blokland, ... Biomedicines 9 (9), 1162, 2021 | 16 | 2021 |
Asthma, COPD and SARS-CoV-2 infection (COVID-19): potential mechanistic insights PAB Wark, PS Pathinayake, MS Eapen, SS Sohal European Respiratory Journal 58 (2), 2021 | 12 | 2021 |