| Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury AG Reaume, JL Elliott, EK Hoffman, NW Kowall, RJ Ferrante, DR Siwek, ... Nature genetics 13 (1), 43-47, 1996 | 1702 | 1996 |
| α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease R Di Maio, PJ Barrett, EK Hoffman, CW Barrett, A Zharikov, A Borah, X Hu, ... Science translational medicine 8 (342), 342ra78-342ra78, 2016 | 663 | 2016 |
| Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia T Kondo, AG Reaume, TT Huang, E Carlson, K Murakami, SF Chen, ... Journal of Neuroscience 17 (11), 4180-4189, 1997 | 569 | 1997 |
| LRRK2 activation in idiopathic Parkinson’s disease R Di Maio, EK Hoffman, EM Rocha, MT Keeney, LH Sanders, ... Science translational medicine 10 (451), eaar5429, 2018 | 489 | 2018 |
| Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss KK Ohlemiller, SL McFadden, DL Ding, DG Flood, AG Reaume, ... Audiology and Neurotology 4 (5), 237-246, 1999 | 305 | 1999 |
| A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease PG Mastroberardino, EK Hoffman, MP Horowitz, R Betarbet, G Taylor, ... Neurobiology of disease 34 (3), 417-431, 2009 | 233 | 2009 |
| Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts TT Huang, M Yasunami, EJ Carlson, AM Gillespie, AG Reaume, ... Archives of biochemistry and biophysics 344 (2), 424-432, 1997 | 211 | 1997 |
| An S1 nuclease-sensitive homopurine/homopyrimidine domain in the c-Ki-ras promoter interacts with a nuclear factor. EK Hoffman, SP Trusko, M Murphy, DL George Proceedings of the National Academy of Sciences 87 (7), 2705-2709, 1990 | 159 | 1990 |
| Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions DG Flood, AG Reaume, JA Gruner, EK Hoffman, JD Hirsch, YG Lin, ... The American journal of pathology 155 (2), 663-672, 1999 | 141 | 1999 |
| Proteasome inhibition enhances the stability of mouse CuZn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis EK Hoffman, HM Wilcox, RW Scott, R Siman Journal of the neurological sciences 139 (1), 15-20, 1996 | 136 | 1996 |
| A genome wide search for alcoholism susceptibility genes SY Hill, S Shen, N Zezza, EK Hoffman, M Perlin, W Allan American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 128 …, 2004 | 125 | 2004 |
| Structural and functional characterization of the promoter region of the mouse c-Ki-ras gene EK Hoffman, SP Trusko, N Freeman, DL George Molecular and cellular biology 7 (7), 2592-2596, 1987 | 100 | 1987 |
| Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene SS Fakharzadeh, L Rosenblum-Vos, M Murphy, EK Hoffman, DL George Genomics 15 (2), 283-290, 1993 | 90 | 1993 |
| Dopaminergic mutations: Within‐family association and linkage in multiplex alcohol dependence families SY Hill, EK Hoffman, N Zezza, A Thalamuthu, DE Weeks, AG Matthews, ... American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147 …, 2008 | 68 | 2008 |
| The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses AG Matthews, EK Hoffman, N Zezza, S Stiffler, SY Hill Journal of Studies on Alcohol and Drugs 68 (5), 625-633, 2007 | 52 | 2007 |
| Gene-targeted non-human mammals deficient in the SOD-1 gene RW Scott, AG Reaume, EK Hoffman US Patent 5,814,300, 1998 | 38 | 1998 |
| Induction of NGF by isoproterenol, 4-methylcatechol and serum occurs by three distinct mechanisms S Carswell, EK Hoffman, K Clopton-Hartpence, HM Wilcox, ME Lewis Molecular brain research 15 (1-2), 145-150, 1992 | 35 | 1992 |
| NADPH oxidase 2 activity in Parkinson's disease MT Keeney, EK Hoffman, K Farmer, CR Bodle, M Fazzari, A Zharikov, ... Neurobiology of disease 170, 105754, 2022 | 33 | 2022 |
| A reliable behavioral assay for the assessment of sustained photophobia in mice E Thiels, EK Hoffman, MB Gorin Current eye research 33 (5-6), 483-491, 2008 | 32 | 2008 |
| Alpha-synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease. Sci Transl Med 8: 342ra378 R Di Maio, PJ Barrett, EK Hoffman, CW Barrett, A Zharikov, A Borah, X Hu, ... | 24 | 2016 |
