| A general method for the synthesis of 2 ‘-O-cyanoethylated oligoribonucleotides having promising hybridization affinity for DNA and RNA and enhanced nuclease resistance H Saneyoshi, K Seio, M Sekine The Journal of organic chemistry 70 (25), 10453-10460, 2005 | 116 | 2005 |
| Squaryl group as a new mimic of phosphate group in modified oligodeoxynucleotides: synthesis and properties of new oligodeoxynucleotide analogues containing an internucleotidic … K Sato, K Seio, M Sekine Journal of the American Chemical Society 124 (43), 12715-12724, 2002 | 90 | 2002 |
| Fluorescent pyrimidopyrimidoindole nucleosides: Control of photophysical characterizations by substituent effects M Mizuta, K Seio, K Miyata, M Sekine The Journal of Organic Chemistry 72 (14), 5046-5055, 2007 | 78 | 2007 |
| Synthesis and properties of 2′-O-methyl-2-thiouridine and oligoribonucleotides containing 2′-O-methyl-2-thiouridine K Shohda, I Okamoto, T Wada, K Seio, M Sekine Bioorganic & medicinal chemistry letters 10 (16), 1795-1798, 2000 | 55 | 2000 |
| Synthesis of 2′-O-[2-(N-Methylcarbamoyl)ethyl]ribonucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide … T Yamada, N Okaniwa, H Saneyoshi, A Ohkubo, K Seio, T Nagata, Y Aoki, ... The Journal of organic chemistry 76 (9), 3042-3053, 2011 | 53 | 2011 |
| Synthesis and properties of oligonucleotides with iodo-substituted aromatic aglycons: investigation of possible halogen bonding base pairs R Tawarada, K Seio, M Sekine The Journal of Organic Chemistry 73 (2), 383-390, 2008 | 51 | 2008 |
| O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method A Ohkubo, Y Ezawa, K Seio, M Sekine Journal of the American Chemical Society 126 (35), 10884-10896, 2004 | 51 | 2004 |
| Synthesis and Properties of a New Fluorescent Bicyclic 4-N-Carbamoyldeoxycytidine Derivative K Miyata, R Tamamushi, A Ohkubo, H Taguchi, K Seio, T Santa, M Sekine Organic Letters 8 (8), 1545-1548, 2006 | 49 | 2006 |
| Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs A Ohkubo, K Yamada, Y Ito, K Yoshimura, K Miyauchi, T Kanamori, ... Nucleic Acids Research 43 (12), 5675-5686, 2015 | 46 | 2015 |
| Proton-block strategy for the synthesis of oligodeoxynucleotides without base protection, capping reaction, and P− N bond cleavage reaction M Sekine, A Ohkubo, K Seio The Journal of Organic Chemistry 68 (14), 5478-5492, 2003 | 45 | 2003 |
| Synthesis of 4-Thiouridine, 6-Thioinosine, and 6-Thioguanosine 3‘,5‘-O-Bisphosphates as Donor Molecules for RNA Ligation and Their Application to the Synthesis … M Kadokura, T Wada, K Seio, M Sekine The Journal of Organic Chemistry 65 (17), 5104-5113, 2000 | 44 | 2000 |
| Synthesis and properties of new nucleotide analogues possessing squaramide moieties as new phosphate isosters K Seio, T Miyashita, K Sato, M Sekine European journal of organic chemistry 2005 (24), 5163-5170, 2005 | 42 | 2005 |
| Synthesis and properties of oligonucleotides having a phosphorus chiral center by incorporation of conformationally rigid 5 ‘-cyclouridylic acid derivatives M Sekine, O Kurasawa, K Shohda, K Seio, T Wada The Journal of Organic Chemistry 65 (20), 6515-6524, 2000 | 42 | 2000 |
| Chemical synthesis and properties of conformationally fixed diuridine monophosphates as building blocks of the RNA turn motif K Seio, T Wada, K Sakamoto, S Yokoyama, M Sekine The Journal of Organic Chemistry 63 (5), 1429-1443, 1998 | 41 | 1998 |
| (+)-3-[2-(Benzo [b] thiophen-2-yl)-2-oxoethyl]-1-azabicyclo [2.2. 2] octane as potent agonists for the α7 nicotinic acetylcholine receptor R Tatsumi, K Seio, M Fujio, J Katayama, T Horikawa, K Hashimoto, ... Bioorganic & medicinal chemistry letters 14 (14), 3781-3784, 2004 | 36 | 2004 |
| 7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein M Tokugawa, Y Masaki, JC Canggadibrata, K Kaneko, T Shiozawa, ... Chemical Communications 52 (19), 3809-3812, 2016 | 35 | 2016 |
| A New Route to 2‘-O-Alkyl-2-thiouridine Derivatives via 4-O-Protection of the Uracil Base and Hybridization Properties of Oligonucleotides Incorporating These … I Okamoto, K Shohda, K Seio, M Sekine The Journal of Organic Chemistry 68 (26), 9971-9982, 2003 | 35 | 2003 |
| New thermolytic carbamoyl groups for the protection of nucleobases A Ohkubo, R Kasuya, K Miyata, H Tsunoda, K Seio, M Sekine Organic & Biomolecular Chemistry 7 (4), 687-694, 2009 | 34 | 2009 |
| Synthesis and properties of oligodeoxynucleotides incorporating a conformationally rigid uridine unit having a cyclic structure at the 5 ‘-terminal site M Sekine, O Kurasawa, K Shohda, K Seio, T Wada The Journal of Organic Chemistry 65 (12), 3571-3578, 2000 | 34 | 2000 |
| ‘Protected DNA Probes’ capable of strong hybridization without removal of base protecting groups A Ohkubo, R Kasuya, K Sakamoto, K Miyata, H Taguchi, H Nagasawa, ... Nucleic acids research 36 (6), 1952-1964, 2008 | 33 | 2008 |
