Palladium-mediated intracellular chemistry RM Yusop, A Unciti-Broceta, EMV Johansson, RM Sánchez-Martín, ... Nature Chemistry 3 (3), 239-243, 2011 | 507 | 2011 |
Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach JT Weiss, JC Dawson, KG Macleod, W Rybski, C Fraser, ... Nature communications 5 (1), 3277, 2014 | 316 | 2014 |
Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis M Sancho-Albero, B Rubio-Ruiz, AM Pérez-López, V Sebastián, ... Nature catalysis 2 (10), 864-872, 2019 | 236 | 2019 |
Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine JT Weiss, JC Dawson, C Fraser, W Rybski, C Torres-Sánchez, M Bradley, ... Journal of medicinal chemistry 57 (12), 5395-5404, 2014 | 206 | 2014 |
AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective: Miniperspective SH Myers, VG Brunton, A Unciti-Broceta Journal of medicinal chemistry 59 (8), 3593-3608, 2016 | 200 | 2016 |
Gold‐triggered uncaging chemistry in living systems AM Pérez‐López, B Rubio‐Ruiz, V Sebastián, L Hamilton, C Adam, ... Angewandte Chemie International Edition 56 (41), 12548-12552, 2017 | 161 | 2017 |
Small molecule kinase inhibitor drugs (1995–2021): medical indication, pharmacology, and synthesis CC Ayala-Aguilera, T Valero, A Lorente-Macias, DJ Baillache, S Croke, ... Journal of Medicinal Chemistry 65 (2), 1047-1131, 2021 | 157 | 2021 |
Synthesis of polystyrene microspheres and functionalization with Pd0 nanoparticles to perform bioorthogonal organometallic chemistry in living cells A Unciti-Broceta, EMV Johansson, RM Yusop, RM Sánchez-Martín, ... nature protocols 7 (6), 1207-1218, 2012 | 138 | 2012 |
Efficient palladium-triggered release of vorinostat from a bioorthogonal precursor B Rubio-Ruiz, JT Weiss, A Unciti-Broceta Journal of Medicinal Chemistry 59 (21), 9974-9980, 2016 | 111 | 2016 |
Bright insights into palladium-triggered local chemotherapy TL Bray, M Salji, A Brombin, AM Pérez-López, B Rubio-Ruiz, ... Chemical Science 9 (37), 7354-7361, 2018 | 88 | 2018 |
Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide–peptoid hybrids A Unciti-Broceta, F Diezmann, CY Ou-Yang, MA Fara, M Bradley Bioorganic & medicinal chemistry 17 (3), 959-966, 2009 | 81 | 2009 |
Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy JT Weiss, NO Carragher, A Unciti-Broceta Scientific reports 5 (1), 9329, 2015 | 78 | 2015 |
Transition metal catalysts for the bioorthogonal synthesis of bioactive agents MON van de L'Isle, MC Ortega-Liebana, A Unciti-Broceta Current opinion in chemical biology 61, 32-42, 2021 | 73 | 2021 |
Rapid discovery and structure–activity relationships of pyrazolopyrimidines that potently suppress breast cancer cell growth via SRC kinase inhibition with exceptional … C Fraser, JC Dawson, R Dowling, DR Houston, JT Weiss, AF Munro, ... Journal of medicinal chemistry 59 (10), 4697-4710, 2016 | 62 | 2016 |
Cationic lipids A Unciti-Broceta, A Liberska, M Bradley US Patent 8,759,104, 2014 | 61 | 2014 |
Bioorthogonal uncaging of the active metabolite of irinotecan by palladium‐functionalized microdevices C Adam, AM Pérez‐López, L Hamilton, B Rubio‐Ruiz, TL Bray, D Sieger, ... Chemistry–A European Journal 24 (63), 16783-16790, 2018 | 58 | 2018 |
ALDH1 bio-activates nifuroxazide to eradicate ALDHHigh melanoma-initiating cells S Sarvi, R Crispin, Y Lu, L Zeng, TD Hurley, DR Houston, ... Cell chemical biology 25 (12), 1456-1469. e6, 2018 | 52 | 2018 |
Next-generation phenotypic screening SJ Warchal, A Unciti-Broceta, NO Carragher Future medicinal chemistry 8 (11), 1331-1347, 2016 | 52 | 2016 |
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis JDG Leach, N Vlahov, P Tsantoulis, RA Ridgway, DJ Flanagan, K Gilroy, ... Nature communications 12 (1), 3464, 2021 | 49 | 2021 |
Recent developments in anticancer kinase inhibitors based on the pyrazolo [3, 4-d] pyrimidine scaffold DJ Baillache, A Unciti-Broceta RSC medicinal chemistry 11 (10), 1112-1135, 2020 | 42 | 2020 |