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Ikuo Masuho
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Pharmacogenomics of GPCR drug targets
AS Hauser, S Chavali, I Masuho, LJ Jahn, KA Martemyanov, DE Gloriam, ...
Cell 172 (1), 41-54. e19, 2018
6252018
Mutations in GNAL cause primary torsion dystonia
T Fuchs, R Saunders-Pullman, I Masuho, MS Luciano, D Raymond, ...
Nature genetics 45 (1), 88-92, 2013
3362013
Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
I Masuho, O Ostrovskaya, GM Kramer, CD Jones, K Xie, KA Martemyanov
Science signaling 8 (405), ra123-ra123, 2015
2332015
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
C Orlandi, E Posokhova, I Masuho, TA Ray, N Hasan, RG Gregg, ...
Journal of Cell Biology 197 (6), 711-719, 2012
1142012
A global map of G protein signaling regulation by RGS proteins
I Masuho, S Balaji, BS Muntean, NK Skamangas, S Chavali, JJG Tesmer, ...
Cell 183 (2), 503-521. e19, 2020
1092020
Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
S Gulati, H Jin, I Masuho, T Orban, Y Cai, E Pardon, KA Martemyanov, ...
Nature communications 9 (1), 1996, 2018
922018
Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila
S Himmelreich, I Masuho, JA Berry, C MacMullen, NK Skamangas, ...
Cell reports 21 (8), 2074-2081, 2017
892017
Retina-specific GTPase accelerator RGS11/Gβ5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons
Y Cao, I Masuho, H Okawa, K Xie, J Asami, PJ Kammermeier, ...
Journal of Neuroscience 29 (29), 9301-9313, 2009
882009
RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling
O Ostrovskaya, K Xie, I Masuho, A Fajardo-Serrano, R Lujan, K Wickman, ...
Elife 3, e02053, 2014
872014
Mutations in GNAL: a novel cause of craniocervical dystonia
KR Kumar, K Lohmann, I Masuho, R Miyamoto, A Ferbert, T Lohnau, ...
JAMA neurology 71 (4), 490-494, 2014
862014
Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ channels
O Saitoh, I Masuho, I Terakawa, S Nomoto, T Asano, Y Kubo
Journal of Biological Chemistry 276 (7), 5052-5058, 2001
822001
LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway
KS Carmon, X Gong, J Yi, L Wu, A Thomas, CM Moore, I Masuho, ...
Journal of Biological Chemistry 292 (36), 14989-15001, 2017
782017
Monitoring G protein activation in cells with BRET
I Masuho, KA Martemyanov, NA Lambert
G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, 107-113, 2015
772015
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
BS Muntean, I Masuho, M Dao, LP Sutton, S Zucca, H Iwamoto, DN Patil, ...
Cell reports 34 (5), 2021
712021
Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans
K Lohmann, I Masuho, DN Patil, H Baumann, E Hebert, S Steinrücke, ...
Human molecular genetics 26 (6), 1078-1086, 2017
682017
Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells
I Masuho, K Xie, KA Martemyanov
Journal of Biological Chemistry 288 (35), 25129-25142, 2013
592013
Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling
I Masuho, NK Skamangas, BS Muntean, KA Martemyanov
Cell systems 12 (4), 324-337. e5, 2021
562021
Essential Role of the m2R-RGS6-IKACh Pathway in Controlling Intrinsic Heart Rate Variability
E Posokhova, D Ng, A Opel, I Masuho, A Tinker, LG Biesecker, ...
PloS one 8 (10), e76973, 2013
562013
Genetic behavioral screen identifies an orphan anti-opioid system
D Wang, HM Stoveken, S Zucca, M Dao, C Orlandi, C Song, I Masuho, ...
Science 365 (6459), 1267-1273, 2019
512019
The complex of G protein regulator RGS9-2 and Gβ5 controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum
K Xie, I Masuho, C Brand, CW Dessauer, KA Martemyanov
Science signaling 5 (239), ra63-ra63, 2012
512012
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