| DNA methylation and somatic mutations converge on the cell cycle and define similar evolutionary histories in brain tumors T Mazor, A Pankov, BE Johnson, C Hong, EG Hamilton, RJA Bell, ... Cancer cell 28 (3), 307-317, 2015 | 275 | 2015 |
| Potential of the conditionally replicative adenovirus Ad5-Δ24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy MLM Lamfers, J Grill, CMF Dirven, VW Van Beusechem, B Geoerger, ... Cancer research 62 (20), 5736-5742, 2002 | 253 | 2002 |
| Glioblastoma‐derived extracellular vesicles modify the phenotype of monocytic cells J de Vrij, SLN Maas, KMC Kwappenberg, R Schnoor, A Kleijn, L Dekker, ... International journal of cancer 137 (7), 1630-1642, 2015 | 216 | 2015 |
| Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment HF van Thuijl, T Mazor, BE Johnson, SD Fouse, K Aihara, C Hong, ... Acta neuropathologica 129, 597-607, 2015 | 188 | 2015 |
| IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo LBC Bralten, NK Kloosterhof, R Balvers, A Sacchetti, L Lapre, M Lamfers, ... Annals of neurology 69 (3), 455-463, 2011 | 173 | 2011 |
| Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model H Jiang, K Clise-Dwyer, KE Ruisaard, X Fan, W Tian, J Gumin, ... PloS one 9 (5), e97407, 2014 | 156 | 2014 |
| The human survivin promoter: a novel transcriptional targeting strategy for treatment of glioma WJ Van Houdt, YS Haviv, B Lu, M Wang, AA Rivera, IV Ulasov, ... Journal of neurosurgery 104 (4), 583-592, 2006 | 140 | 2006 |
| Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing J De Vrij, SLN Maas, M Van Nispen, M Sena-Esteves, RWA Limpens, ... Nanomedicine 8 (9), 1443-1458, 2013 | 127 | 2013 |
| Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished VW Van Beusechem, J Grill, DCJ Mastenbroek, TJ Wickham, ... Journal of virology 76 (6), 2753-2762, 2002 | 109 | 2002 |
| Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging MLM Lamfers, G Fulci, D Gianni, Y Tang, K Kurozumi, B Kaur, ... Molecular Therapy 14 (6), 779-788, 2006 | 108 | 2006 |
| Adenoviral expression of a urokinase receptor–targeted protease inhibitor inhibits neointima formation in murine and human blood vessels PHA Quax, MLM Lamfers, JWHP Lardenoye, JM Grimbergen, ... Circulation 103 (4), 562-569, 2001 | 98 | 2001 |
| Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors VW Van Beusechem, DCJ Mastenbroek, PB Van den Doel, MLM Lamfers, ... Gene therapy 10 (23), 1982-1991, 2003 | 96 | 2003 |
| Evolving gene therapy approaches for osteosarcoma using viral vectors MA Witlox, ML Lamfers, P Wuisman, DT Curiel, GP Siegal Bone 40 (4), 797-812, 2007 | 85 | 2007 |
| Establishing the lysine-rich protein CEST reporter gene as a CEST MR imaging detector for oncolytic virotherapy CT Farrar, JS Buhrman, G Liu, A Kleijn, MLM Lamfers, MT McMahon, ... Radiology 275 (3), 746-754, 2015 | 83 | 2015 |
| The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity A Kleijn, J Kloezeman, E Treffers-Westerlaken, G Fulci, S Leenstra, ... PloS one 9 (5), e97495, 2014 | 80 | 2014 |
| Histone deacetylase inhibitors upregulate expression of the coxsackie adenovirus receptor (CAR) preferentially in bladder cancer cells MD Sachs, M Ramamurthy, H Poel, TJ Wickham, M Lamfers, W Gerritsen, ... Cancer gene therapy 11 (7), 477-486, 2004 | 80 | 2004 |
| The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro J Grill, MLM Lamfers, VW Van Beusechem, CM Dirven, DS Pherai, ... Molecular Therapy 6 (5), 609-614, 2002 | 80 | 2002 |
| Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix–associated gene modules RK Balvers, A Kleijn, JJ Kloezeman, PJ French, A Kremer, ... Neuro-oncology 15 (12), 1684-1695, 2013 | 76 | 2013 |
| Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment WBL Van Den Bossche, A Kleijn, CE Teunissen, JSA Voerman, ... Neuro-oncology 20 (11), 1494-1504, 2018 | 75 | 2018 |
| Convection enhanced delivery of the oncolytic adenovirus Delta24-RGD in patients with recurrent GBM: a phase I clinical trial including correlative studies EHP Van Putten, A Kleijn, VW Van Beusechem, D Noske, CHJ Lamers, ... Clinical Cancer Research 28 (8), 1572-1585, 2022 | 71 | 2022 |
