| Challenges and perspectives on the development of small-molecule EGFR inhibitors against T790M-mediated resistance in non-small-cell lung cancer: miniperspective Z Song, Y Ge, C Wang, S Huang, X Shu, K Liu, Y Zhou, X Ma Journal of medicinal chemistry 59 (14), 6580-6594, 2016 | 97 | 2016 |
| Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies Z Song, M Wang, Y Ge, XP Chen, Z Xu, Y Sun, XF Xiong Acta Pharmaceutica Sinica B 11 (1), 13-29, 2021 | 85 | 2021 |
| Heterotrimeric G proteins as therapeutic targets in drug discovery J Li, Y Ge, JX Huang, K Strømgaard, X Zhang, XF Xiong Journal of medicinal chemistry 63 (10), 5013-5030, 2019 | 40 | 2019 |
| Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines H Yu, Y Li, Y Ge, Z Song, C Wang, S Huang, Y Jin, X Han, Y Zhen, K Liu, ... European Journal of Medicinal Chemistry 110, 195-203, 2016 | 31 | 2016 |
| Synthesis and biological evaluation of azole-diphenylpyrimidine derivatives (AzDPPYs) as potent T790M mutant form of epidermal growth factor receptor inhibitors Z Song, Y Jin, Y Ge, C Wang, J Zhang, Z Tang, J Peng, K Liu, Y Li, X Ma Bioorganic & Medicinal Chemistry 24 (21), 5505-5512, 2016 | 30 | 2016 |
| Identification of highly potent BTK and JAK3 dual inhibitors with improved activity for the treatment of B-cell lymphoma Y Ge, C Wang, S Song, J Huang, Z Liu, Y Li, Q Meng, J Zhang, J Yao, ... European Journal of Medicinal Chemistry 143, 1847-1857, 2018 | 28 | 2018 |
| Cleavable and tunable cysteine-specific arylation modification with aryl thioethers J Li, JJ Deng, Z Yin, QL Hu, Y Ge, Z Song, Y Zhang, ASC Chan, H Li, ... Chemical Science 12 (14), 5209-5215, 2021 | 27 | 2021 |
| Silanol: a bifunctional group for peptide synthesis and late-stage functionalization QL Hu, KQ Hou, J Li, Y Ge, ZD Song, ASC Chan, XF Xiong Chemical Science 11 (23), 6070-6074, 2020 | 27 | 2020 |
| Discovery of Novel Bruton’s Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl-9H-purin-2-amine Scaffold Y Ge, Y Jin, C Wang, J Zhang, Z Tang, J Peng, K Liu, Y Li, Y Zhou, X Ma ACS Medicinal Chemistry Letters 7 (12), 1050-1055, 2016 | 24 | 2016 |
| Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines H Liu, B Wu, Y Ge, J Huang, S Song, C Wang, J Yao, K Liu, Y Li, Y Li, ... Bioorganic & Medicinal Chemistry 25 (24), 6313-6321, 2017 | 21 | 2017 |
| Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton’s tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic … Y Ge, H Yang, C Wang, Q Meng, L Li, H Sun, Y Zhen, K Liu, Y Li, X Ma Bioorganic & Medicinal Chemistry 25 (2), 765-772, 2017 | 20 | 2017 |
| Asymmetric synthesis of oxindole-derived vicinal tetrasubstituted acyclic amino acid derivatives by the Mannich-type reaction KQ Hou, F Zhou, XP Chen, Y Ge, ASC Chan, XF Xiong The Journal of Organic Chemistry 85 (15), 9661-9671, 2020 | 14 | 2020 |
| C-2 (E)-4-(Styryl) aniline substituted diphenylpyrimidine derivatives (Sty-DPPYs) as specific kinase inhibitors targeting clinical resistance related EGFRT790M mutant A Song, J Zhang, Y Ge, C Wang, Q Meng, Z Tang, J Peng, K Liu, Y Li, ... Bioorganic & Medicinal Chemistry 25 (10), 2724-2729, 2017 | 14 | 2017 |
| Identification of novel Pyrrolo [2, 3-d] Pyrimidine-based KRAS G12C inhibitors with anticancer effects Z Song, L Lou, G Fan, L Liu, Y Ge, H Liu, ASC Chan, X Zhang, XF Xiong European Journal of Medicinal Chemistry 245, 114907, 2023 | 12 | 2023 |
| Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma Y Ge, JJ Deng, J Zhu, L Liu, S Ouyang, Z Song, X Zhang, XF Xiong Acta Pharmaceutica Sinica B 12 (8), 3326-3340, 2022 | 11 | 2022 |
| Design, synthesis, and evaluation of small molecule Gαq/11 protein inhibitors for the treatment of uveal melanoma Y Ge, S Shi, JJ Deng, XP Chen, Z Song, L Liu, L Lou, X Zhang, XF Xiong Journal of Medicinal Chemistry 64 (6), 3131-3152, 2021 | 11 | 2021 |
| Demethylative alkylation of methionine residue by employing the sulfonium as the key intermediate QL Hu, JT Liu, J Li, Y Ge, Z Song, ASC Chan, XF Xiong Organic Letters 23 (21), 8543-8548, 2021 | 8 | 2021 |
| Synthesis and evaluation of imidazo [1, 2-a] pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma JJ Deng, L Liu, Y Ge, Z Song, J Huang, G Fan, XF Xiong European Journal of Medicinal Chemistry 239, 114520, 2022 | 3 | 2022 |
| GQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway H Ma, Y Ge, C Di, X Wang, B Qin, A Wang, W Hu, Z Lai, X Xiong, R Qi International Journal of Molecular Sciences 25 (19), 10297, 2024 | | 2024 |
