关注
Yutaka Matsuda
Yutaka Matsuda
Director Antibody-drug Conjugate Chemistry at Exelixis
在 exelixis.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
AJICAP: affinity peptide mediated regiodivergent functionalization of native antibodies
K Yamada, N Shikida, K Shimbo, Y Ito, Z Khedri, Y Matsuda, ...
Angewandte Chemie 131 (17), 5648-5653, 2019
1032019
An overview of process development for antibody-drug conjugates produced by chemical conjugation technology
Y Matsuda, BA Mendelsohn
Expert Opinion on Biological Therapy 21 (7), 963-975, 2021
522021
Recent advances in drug–antibody ratio determination of antibody–drug conjugates
Y Matsuda, BA Mendelsohn
Chemical and Pharmaceutical Bulletin 69 (10), 976-983, 2021
382021
Comparison of analytical methods for antibody–drug conjugates produced by chemical site-specific conjugation: first-generation AJICAP
Y Matsuda, V Robles, MC Malinao, J Song, BA Mendelsohn
Analytical chemistry 91 (20), 12724-12732, 2019
352019
Current approaches for the purification of antibody–drug conjugates
Y Matsuda
Journal of Separation Science 45 (1), 27-37, 2022
342022
A Purification Strategy Utilizing Hydrophobic Interaction Chromatography to Obtain Homogeneous Species from a Site-Specific Antibody Drug Conjugate Produced by AJICAP™ First …
Y Matsuda, M Leung, T Okuzumi, B Mendelsohn
Antibodies 9 (2), 16, 2020
322020
Gram-scale antibody–drug conjugate synthesis by site-specific chemical conjugation: AJICAP first generation
Y Matsuda, K Yamada, T Okuzumi, BA Mendelsohn
Organic Process Research & Development 23 (12), 2647-2654, 2019
312019
Proof of site-specificity of antibody-drug conjugates produced by chemical conjugation technology: AJICAP first generation
Y Matsuda, MC Malinao, V Robles, J Song, K Yamada, BA Mendelsohn
Journal of Chromatography B 1140, 121981, 2020
302020
Good manufacturing practice strategy for antibody–drug conjugate synthesis using site-specific chemical conjugation: first-generation AJICAP
Y Matsuda, C Clancy, Z Tawfiq, V Robles, BA Mendelsohn
ACS omega 4 (24), 20564-20570, 2019
292019
AJICAP second generation: improved chemical site-specific conjugation technology for antibody–drug conjugate production
T Fujii, Y Matsuda, T Seki, N Shikida, Y Iwai, Y Ooba, K Takahashi, ...
Bioconjugate Chemistry 34 (4), 728-738, 2023
282023
Synthesis and biological evaluation of antibody drug conjugates based on an antibody expression system: conamax
Z Tawfiq, NC Caiazza, S Kambourakis, Y Matsuda, B Griffin, JC Lippmeier, ...
ACS omega 5 (13), 7193-7200, 2020
282020
Chemical site-specific conjugation platform to improve the pharmacokinetics and therapeutic index of Antibody–Drug conjugates
Y Matsuda, T Seki, K Yamada, Y Ooba, K Takahashi, T Fujii, S Kawaguchi, ...
Molecular Pharmaceutics 18 (11), 4058-4066, 2021
262021
Analytical Comparison of Antibody-Drug Conjugates Based on Good Manufacturing Practice Strategies
Z TAWFIQ, Y MATSUDA, MJ ALFONSO, C CLANCY, V ROBLES, ...
Analytical Sciences, 19P465, 2020
262020
Application of Native Ion Exchange Mass Spectrometry to Intact and Subunit Analysis of Site-Specific Antibody–Drug Conjugates Produced by AJICAP First Generation Technology
Y Matsuda, M Kliman, BA Mendelsohn
Journal of the American Society for Mass Spectrometry, 2020
262020
Synthetic studies on polymaxenolides: synthesis and structure elucidation of nominal epoxyafricanane and other africane-type sesquiterpenoids
Y Matsuda, Y Endo, Y Saikawa, M Nakata
The Journal of Organic Chemistry 76 (15), 6258-6263, 2011
262011
Insight into temperature dependency and design of experiments towards process development for cysteine‐based antibody‐drug conjugates
Y Matsuda, Z Tawfiq, M Leung, BA Mendelsohn
ChemistrySelect 5 (28), 8435-8439, 2020
252020
Antibody–drug conjugate synthesis using continuous flow microreactor technology
Y Nakahara, BA Mendelsohn, Y Matsuda
Organic Process Research & Development 26 (9), 2766-2770, 2022
242022
Chromatographic analysis of site-specific antibody-drug conjugates produced by AJICAP first-generation technology using a recombinant FcγIIIa receptor-ligand affinity column
Y Matsuda, A Chakrabarti, K Takahashi, K Yamada, K Nakata, T Okuzumi, ...
Journal of Chromatography B 1177, 122753, 2021
232021
In-situ Reverse Phased HPLC Analysis of Intact Antibody-Drug Conjugates
Y Matsuda, M Leung, Z Tawfiq, T Fujii, BA Mendelsohn
Analytical Sciences 37 (8), 1171-1176, 2021
212021
Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates
T Fujii, C Reiling, C Quinn, M Kliman, BA Mendelsohn, Y Matsuda
Exploration of Targeted Anti-tumor Therapy 2 (6), 576, 2021
192021
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