Facile Chemoenzymatic Strategies for the Synthesis and Utilization of S‐Adenosyl‐L‐Methionine Analogues S Singh, J Zhang, TD Huber, M Sunkara, K Hurley, RD Goff, G Wang, ... Angewandte Chemie International Edition 53 (15), 3965-3969, 2014 | 152 | 2014 |
Targeting the bacterial division protein FtsZ KA Hurley, TMA Santos, GM Nepomuceno, V Huynh, JT Shaw, DB Weibel Journal of medicinal chemistry 59 (15), 6975-6998, 2016 | 133 | 2016 |
Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus F Wang, S Singh, J Zhang, TD Huber, KE Helmich, M Sunkara, KA Hurley, ... The FEBS journal 281 (18), 4224-4239, 2014 | 51 | 2014 |
Synthesis of a γ-Lactam Library via Formal Cycloaddition of Imines and Substituted Succinic Anhydrides DQ Tan, AL Atherton, AJ Smith, C Soldi, KA Hurley, JC Fettinger, JT Shaw ACS Combinatorial Science 14 (3), 218-223, 2012 | 47 | 2012 |
Gyramides prevent bacterial growth by inhibiting DNA gyrase and altering chromosome topology M Rajendram, KA Hurley, MH Foss, KM Thornton, JT Moore, JT Shaw, ... ACS chemical biology 9 (6), 1312-1319, 2014 | 46 | 2014 |
N-Benzyl-3-sulfonamidopyrrolidines Are a New Class of Bacterial DNA Gyrase Inhibitors MH Foss, KA Hurley, NA Sorto, LL Lackner, KM Thornton, JT Shaw, ... ACS medicinal chemistry letters 2 (4), 289-292, 2011 | 25 | 2011 |
Membrane-targeting DCAP analogues with broad-spectrum antibiotic activity against pathogenic bacteria KA Hurley, VA Heinrich, JR Hershfield, ST Demons, DB Weibel ACS Medicinal Chemistry Letters 6 (4), 466-471, 2015 | 18 | 2015 |
Impact of manipulation of glycerol/diol dehydratase activity on intestinal microbiota ecology and metabolism A Ramirez Garcia, J Zhang, A Greppi, F Constancias, E Wortmann, ... Environmental microbiology 23 (3), 1765-1779, 2021 | 13 | 2021 |
Targeting quinolone-and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase KA Hurley, TMA Santos, MR Fensterwald, M Rajendran, JT Moore, ... MedChemComm 8 (5), 942-951, 2017 | 9 | 2017 |
Pathogenic and commensal gut bacteria harboring Glycerol/Diol dehydratase metabolize glycerol and produce DNA-reactive Acrolein A Ramirez Garcia, K Hurley, G Marastoni, M Diard, S Hofer, A Greppi, ... Chemical research in toxicology 35 (10), 1840-1850, 2022 | 8 | 2022 |
5-Alkyloxytryptamines are membrane-targeting, broad-spectrum antibiotics KC Faulkner, KA Hurley, DB Weibel Bioorganic & medicinal chemistry letters 26 (22), 5539-5544, 2016 | 8 | 2016 |
DCAP: A Broad‐spectrum Antibiotic that Targets the Cytoplasmic Membrane of Bacteria V Heinrich, K Hurley, T Santos, D Weibel The FASEB Journal 29, 575.6, 2015 | 4 | 2015 |
Anaerobutyricum hallii promotes the functional depletion of a food carcinogen in diverse healthy fecal microbiota A Ramirez Garcia, A Greppi, F Constancias, HJ Ruscheweyh, J Gasser, ... Frontiers in Microbiomes 2, 1194516, 2023 | 3 | 2023 |
Antimicrobial compounds, compositions and methods of use thereof DB Weibel, KA Hurley, KC Faulkner US Patent 9,440,920, 2016 | 1 | 2016 |
Enzymatic Acrolein Production System and Its Impact on Human Cells KA Hurley, J Folz, J Zgraggen, TN Cruz, S Diedrich, SJ Sturla Chemical Research in Toxicology 37 (8), 1374-1381, 2024 | | 2024 |
Dual DNA and DNA repair protein damage by acrolein in colon epithelial cells T Cruz, KA Hurley, J Zgraggen, S Diedrich, SJ Sturla Toxicology Letters 350, S233, 2021 | | 2021 |
Chemical metabolism and toxicological relevance of microbial glycerol dehydratase from human gut microbiota J Zhang, K Hurley, A Ramirez, C Lacroix, C Schwab, S Sturla ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019 | | 2019 |
Endogenous microbial generation of acrolein: Strategies to assess the effects of intestinal acrolein formation K Hurley, A Ramirez-Garcia, S Diedrich, J Zhang, C Lacroix, E Slack, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019 | | 2019 |
Antimicrobial compounds, compositions and methods of use thereof DB Weibel, YJ Eun, MH Foss, KA Hurley US Patent 10,314,816, 2019 | | 2019 |
Human gut microbial glycerol dehydratase function: impact on chemical metabolism and toxicological relevance S Sturla, J Zhang, K Hurley, MT Empl, M Schneider, G Breves, ... | | 2019 |