Hyperactive Ras in developmental disorders and cancer S Schubbert, K Shannon, G Bollag Nature Reviews Cancer 7 (4), 295-308, 2007 | 1969 | 2007 |
Functional genomic landscape of acute myeloid leukaemia JW Tyner, CE Tognon, D Bottomly, B Wilmot, SE Kurtz, SL Savage, ... Nature 562 (7728), 526-531, 2018 | 1108 | 2018 |
Germline KRAS mutations cause Noonan syndrome S Schubbert, M Zenker, SL Rowe, S Böll, C Klein, G Bollag, ... Nature genetics 38 (3), 331-336, 2006 | 867 | 2006 |
The rate of telomere sequence loss in human leukocytes varies with age RW Frenck Jr, EH Blackburn, KM Shannon Proceedings of the National Academy of Sciences 95 (10), 5607-5610, 1998 | 782 | 1998 |
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon KM Haigis, KR Kendall, Y Wang, A Cheung, MC Haigis, JN Glickman, ... Nature genetics 40 (5), 600-608, 2008 | 706 | 2008 |
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells G Bollag, DW Clapp, S Shih, F Adler, YY Zhang, P Thompson, BJ Lange, ... Nature genetics 12 (2), 144-148, 1996 | 694 | 1996 |
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders KM Shannon, P O'Connell, GA Martin, D Paderanga, K Olson, P Dinndorf, ... New England Journal of Medicine 330 (9), 597-601, 1994 | 507 | 1994 |
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis ML Loh, S Vattikuti, S Schubbert, MG Reynolds, E Carlson, KH Lieuw, ... Blood 103 (6), 2325-2331, 2004 | 499 | 2004 |
Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants KM Shannon, JF Keith III, WC Mentzer, RA Ehrenkranz, MS Brown, ... Pediatrics 95 (1), 1-8, 1995 | 413 | 1995 |
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder BS Braun, DA Tuveson, N Kong, DT Le, SC Kogan, J Rozmus, ... Proceedings of the National Academy of Sciences 101 (2), 597-602, 2004 | 361 | 2004 |
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia C Chen, Y Liu, AR Rappaport, T Kitzing, N Schultz, Z Zhao, AS Shroff, ... Cancer cell 25 (5), 652-665, 2014 | 348 | 2014 |
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia ML Loh, DS Sakai, C Flotho, M Kang, M Fliegauf, S Archambeault, ... Blood, The Journal of the American Society of Hematology 114 (9), 1859-1863, 2009 | 347 | 2009 |
Outcomes in CCG-2961, a children's oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children's oncology group BJ Lange, FO Smith, J Feusner, DR Barnard, P Dinndorf, S Feig, ... Blood, The Journal of the American Society of Hematology 111 (3), 1044-1053, 2008 | 343 | 2008 |
Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders L Side, B Taylor, M Cayouette, E Conner, P Thompson, M Luce, ... New England Journal of Medicine 336 (24), 1713-1720, 1997 | 323 | 1997 |
GTPase activating proteins: critical regulators of intracellular signaling S Donovan, KM Shannon, G Bollag Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1602 (1), 23-45, 2002 | 312 | 2002 |
Childhood monosomy 7: epidemiology, biology, and mechanistic implications S Luna-Fineman, KM Shannon, BJ Lange | 294 | 1995 |
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates N Kotecha, NJ Flores, JM Irish, EF Simonds, DS Sakai, S Archambeault, ... Cancer cell 14 (4), 335-343, 2008 | 284 | 2008 |
Myelodysplastic and myeloproliferative disorders of childhood: a study of 167 patients S Luna-Fineman, KM Shannon, SK Atwater, J Davis, M Masterson, ... Blood, The Journal of the American Society of Hematology 93 (2), 459-466, 1999 | 270 | 1999 |
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells E Kim, P Ambroziak, JC Otto, B Taylor, M Ashby, K Shannon, PJ Casey, ... Journal of Biological Chemistry 274 (13), 8383-8390, 1999 | 255 | 1999 |
Mutations of the NF1 Gene in Children With Juvenile Myelomonocytic Leukemia Without Clinical Evidence of Neurofibromatosis, Type 1 LE Side, PD Emanuel, B Taylor, J Franklin, P Thompson, RP Castleberry, ... Blood, The Journal of the American Society of Hematology 92 (1), 267-272, 1998 | 238 | 1998 |